Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Cross-Linked Lignin/Agarose Hydrogels Coated With Iron Oxide Magnetic Nanoparticles for in Vitro Hyperthermia Cancer Therapy Publisher



Eivazzadehkeihan R1 ; Khalili F1 ; Radinekiyan F1 ; Maleki A1 ; Mahdavi M2 ; Bani MS3 ; Bahreinizad H4 ; Babaniamansour P5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran
  2. 2. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran
  4. 4. Mechanical Engineering Department, Sahand University of Technology, Tabriz, Iran
  5. 5. Department of Biomedical Engineering, University of Kentucky, Lexington, United States

Source: Journal of Materials Research Published:2022


Abstract

Magnetic hydrogel nanobiocomposites with new biomimetic features have emerged as a new generation of biocompatible structures in biomedical approaches, especially cancer therapy. In this regard, a novel nanobiocomposite is designed and synthesized based on the formation of cross-linked lignin/agarose hydrogel substrate and its functionalization with Fe3O4 magnetic nanoparticles. The physical and chemical features of magnetic cross-linked lignin/agarose nanobiocomposite were characterized using FT-IR, EDX, FE-SEM, TEM, XRD, VSM analyses and the swelling ratio and sol–gel fraction tests. Given the in vitro cytotoxicity assay and applying the highest concentration (1000 μg/mL) of this new nanobiocomposite, the cell viability percentage of Hu02 cell line was calculated 91.05% after 72 h. Furthermore, the potential of this biocompatible and magnetic responsive nanostructure was assessed for magnetic hyperthermia application. Among different concentrations (1 mg/mL, 2 mg/mL, 5 mg/mL, and 10 mg/mL), the maximum amount of specific absorption rate (63.11 W/g) was determined by the lowest concentration of nanobiocomposite (l mg/mL). Therefore, it can be mentioned that this biocompatible nanobiocomposite can be considered as a suitable platform for magnetic fluid hyperthermia and cancer treatment. Graphical abstract: Magnetic lignin/agarose hydrogel as a novel nanobiocomposite for hyperthermia application. [Figure not available: see fulltext.] © 2022, The Author(s), under exclusive licence to The Materials Research Society.