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Magnetic Xanthan Gum-Silk Fibroin Hydrogel: A Nanocomposite for Biological and Hyperthermia Applications Publisher Pubmed



Aliabadi HAM1 ; Forouzandehmalati M2 ; Hassanzadehafruzi F2 ; Noruzi EB3 ; Ganjali F2 ; Kashtiaray A2 ; Bani MS4 ; Eftekhari RB5 ; Eivazzadehkeihan R2 ; Maleki A2
Authors
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Authors Affiliations
  1. 1. Advanced Chemical Studies Lab, Department of Chemistry, K. N. Toosi University of Technology, Tehran, Iran
  2. 2. Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran
  3. 3. Faculty of Chemistry, Department of Inorganic Chemistry, University of Tabriz, Tabriz, Iran
  4. 4. Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran
  5. 5. Department of Pharmaceuticals, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Biological Macromolecules Published:2023


Abstract

A magnetic xanthan hydrogel/silk fibroin nanobiocomposite (XG hydrogel/SF/Fe3O4) was designed, fabricated, and characterized using analyzing methods such as FT-IR, EDX, FE-SEM, XRD, TGA, and VSM to evaluate the exact structure of product nanobiocomposite. The FE-SEM images reveal the presence of spherical shapes exhibiting a narrow size range and homogeneous distribution, measuring between 30 and 35 nm in diameter. The VSM analysis demonstrates the superparamagnetic properties of the XG hydrogel/SF/Fe3O4 nanobiocomposite, exhibiting a magnetic saturation of 54 emu/g at room temperature. The biological response of the nanobiocomposite scaffolds was assessed through cell viability and red blood cell hemolytic assays. MCF10A cells were exposed to a concentration of 1.75 mg/mL of the nanobiocomposite, and after 2 and 3 days, the cell viability was found to be 96.95 % and 97.02 %, respectively. The hemolytic effect was nearly 0 % even at higher concentrations (2 mg/mL). Furthermore, the magnetic nanobiocomposite showed excellent potential for hyperthermia applications, with a maximum specific absorption rate of 7 W/g for 1 mg/mL of the sample under a magnetic field in different frequencies (100, 200, 300, and 400 MHz) and 5 to 20 min time intervals. © 2023
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