Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Regenerative Medicine: Injectable Cell-Based Therapeutics and Approved Products Publisher Pubmed



Golchin A1 ; Shams F2 ; Kangari P3 ; Azari A4 ; Hosseinzadeh S4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Student Research Committee, Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shiraz University of Medical Sciences, Shiraz, Fars, Iran
  4. 4. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Advances in Experimental Medicine and Biology Published:2020


Abstract

Cellular-based therapies have drawn a great deal of attention thanks to their regenerative medicine approaches to treat incurable diseases and specific injuries. In this regard, injectable cell delivery systems could actualize the therapeutically beneficial outcomes of cell-based therapeutic products. These systems have found considerable clinical uses. Hence, the recent studies have focused on developing injectable bio-constructs to protect transplanted cells during delivery and stimulating endogenous regeneration through interactions of these cells and host tissue. This paper introduces a framework, as a general concept, to improve cell delivery systems for cell-based therapeutic products. Studies on stable injectable carriers can enhance cell homing, proliferation, viability, dressing of irregular shape of target sites, and subsequently support transplanted cell functionality. However, more studies should be conducted on new technologies for the injectable cell-based product for cell delivery and the clinical applications. © Springer Nature Switzerland AG 2019.
Related Docs
View other Related Docs
1. Mesenchymal Stromal Cells and Car-T Cells in Regenerative Medicine: The Homing Procedure and Their Effective Parameters, European Journal of Haematology (2024)
2. Biological Products: Cellular Therapy and Fda Approved Products, Stem Cell Reviews and Reports (2019)
3. Stem Cell Therapy Potency in Personalizing Severe Covid-19 Treatment, Stem Cell Reviews and Reports (2021)
4. Wound Healing Improvement by Curcumin-Loaded Electrospun Nanofibers and Bfp-Mscs As a Bioactive Dressing, Polymers for Advanced Technologies (2020)
5. Optical Fluorescence Imaging With Shortwave Infrared Light Emitter Nanomaterials for in Vivo Cell Tracking in Regenerative Medicine, Journal of Cellular and Molecular Medicine (2019)
6. The Clinical Trials of Mesenchymal Stem Cell Therapy in Skin Diseases: An Update and Concise Review, Current Stem Cell Research and Therapy (2019)
7. Biological Aspects and Clinical Applications of Mesenchymal Stem Cells: Key Features You Need to Be Aware Of, Current Pharmaceutical Biotechnology (2021)
8. The Bilayer Skin Substitute Based on Human Adipose-Derived Mesenchymal Stem Cells and Neonate Keratinocytes on the 3D Nanofibrous Pcl-Platelet Gel Scaffold, Polymer Bulletin (2022)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (2)
Hamid Reza Mirzaei (1)
Other Related Docs
9. Mesenchymal Stem Cells in the Treatment of Amyotrophic Lateral Sclerosis, Current Stem Cell Research and Therapy (2016)
10. The Clinical Trials of Mesenchymal Stromal Cells Therapy, Stem Cells International (2021)
11. Effect of 17Β-Estradiol on Mediators Involved in Mesenchymal Stromal Cell Trafficking in Cell Therapy of Diabetes, Cytotherapy (2015)
12. Tracking of Intraperitoneally and Direct Intrahepatic Administered Mesenchymal Stem Cells Expressing Mir-146A-5P in Mice Hepatic Tissue, Health Biotechnology and Biopharma (2020)
13. Nanotechnology and Bioengineering Approaches to Improve the Potency of Mesenchymal Stem Cell As an Off-The-Shelf Versatile Tumor Delivery Vehicle, Medicinal Research Reviews (2024)
14. The Promising Approach of Mscs Therapy for Covid-19 Treatment, Cell and Tissue Banking (2023)
15. Advancing Mesenchymal Stem Cell Therapy With Crispr/Cas9 for Clinical Trial Studies, Advances in Experimental Medicine and Biology (2020)
16. Promotion of Cell-Based Therapy: Special Focus on the Cooperation of Mesenchymal Stem Cell Therapy and Gene Therapy for Clinical Trial Studies, Advances in Experimental Medicine and Biology (2018)
17. Carboxymethylated Polysaccharides in Drug Delivery, Tailor-Made Polysaccharides in Drug Delivery (2022)
18. Potential Therapeutic Options for Covid-19: An Update on Current Evidence, European Journal of Medical Research (2022)
19. Application of Mesenchymal Stem Cells (Mscs) in Neurodegenerative Disorders: History, Findings, and Prospective Challenges, Pathology Research and Practice (2023)
20. Application of Mesenchymal Stem Cells in Melanoma: A Potential Therapeutic Strategy for Delivery of Targeted Agents, Current Medicinal Chemistry (2016)
21. Recent Advances in Regenerative Medicine Strategies for Cancer Treatment, Biomedicine and Pharmacotherapy (2021)