Heterologous Immunization With Inactivated Vaccine Followed by Mrna-Booster Elicits Strong Immunity Against Sars-Cov-2 Omicron Variant

Heterologous Immunization With Inactivated Vaccine Followed by Mrna-Booster Elicits Strong Immunity Against Sars-Cov-2 Omicron Variant Publisher Pubmed

Zuo F¹ ; Abolhassani H¹ ; Du L¹ ; Piralla A² ; Bertoglio F³ ; De Camposmata L¹ ; Wan H¹ ; Schubert M³ ; Cassaniti I² ; Wang Y¹ ; Sammartino JC² ; Sun R¹ ; Vlachiotis S¹ ; Bergami F² Show All Authors

Zuo F¹
Abolhassani H¹
Du L¹
Piralla A²
Bertoglio F³
De Camposmata L¹
Wan H¹
Schubert M³
Cassaniti I²
Wang Y¹
Sammartino JC²
Sun R¹
Vlachiotis S¹
Bergami F²
Kumagaibraesch M⁴
Andrell J⁵
Zhang Z⁶
Xue Y⁷
Wenzel EV^{3, 8}
Calzolai L⁹
Varani L¹⁰
Rezaei N¹¹
Chavoshzadeh Z¹²
Baldanti F^{2, 13}
Hust M³
Hammarstrom L¹
Marcotte H¹
Panhammarstrom Q¹

Source: Nature Communications Published:2022

Abstract

The recent emergence of the Omicron variant has raised concerns on vaccine efficacy and the urgent need to study more efficient vaccination strategies. Here we observed that an mRNA vaccine booster in individuals vaccinated with two doses of inactivated vaccine significantly increased the plasma level of specific antibodies that bind to the receptor-binding domain (RBD) or the spike (S) ectodomain (S1 + S2) of both the G614 and the Omicron variants, compared to two doses of homologous inactivated vaccine. The level of RBD- and S-specific IgG antibodies and virus neutralization titers against variants of concern in the heterologous vaccination group were similar to that in individuals receiving three doses of homologous mRNA-vaccine or a boost of mRNA vaccine after infection, but markedly higher than that in individuals receiving three doses of a homologous inactivated vaccine. This heterologous vaccination regime furthermore significantly enhanced the RBD-specific memory B cell response and S1-specific T cell response, compared to two or three doses of homologous inactivated vaccine. Our study demonstrates that mRNA vaccine booster in individuals vaccinated with inactivated vaccines can be highly beneficial, as it markedly increases the humoral and cellular immune responses against the virus, including the Omicron variant. © 2022, The Author(s).

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Style	Citing Format
MLA	Zuo F, et al.. "Heterologous Immunization With Inactivated Vaccine Followed by Mrna-Booster Elicits Strong Immunity Against Sars-Cov-2 Omicron Variant." Nature Communications, vol. 13, no. 1, 2022, pp. -.
APA	Zuo F, Abolhassani H, Du L, Piralla A, Bertoglio F, De Camposmata L, Wan H, Schubert M, Cassaniti I, Wang Y, Sammartino JC, Sun R, Vlachiotis S, Bergami F, Kumagaibraesch M, Andrell J, Zhang Z, Xue Y, Wenzel EV, ... Panhammarstrom Q (2022). Heterologous Immunization With Inactivated Vaccine Followed by Mrna-Booster Elicits Strong Immunity Against Sars-Cov-2 Omicron Variant. Nature Communications, 13(1), -.
Chicago	Zuo F, Abolhassani H, Du L, Piralla A, Bertoglio F, De Camposmata L, Wan H, et al.. "Heterologous Immunization With Inactivated Vaccine Followed by Mrna-Booster Elicits Strong Immunity Against Sars-Cov-2 Omicron Variant." Nature Communications 13, no. 1 (2022): -.
Harvard	Zuo F et al. (2022) 'Heterologous Immunization With Inactivated Vaccine Followed by Mrna-Booster Elicits Strong Immunity Against Sars-Cov-2 Omicron Variant', Nature Communications, 13(1), pp. -.
Vancouver	Zuo F, Abolhassani H, Du L, Piralla A, Bertoglio F, De Camposmata L, et al.. Heterologous Immunization With Inactivated Vaccine Followed by Mrna-Booster Elicits Strong Immunity Against Sars-Cov-2 Omicron Variant. Nature Communications. 2022;13(1):-.
BibTex	@article{ author = {Zuo F and Abolhassani H and Du L and Piralla A and Bertoglio F and De Camposmata L and Wan H and Schubert M and Cassaniti I and Wang Y and Sammartino JC and Sun R and Vlachiotis S and Bergami F and Kumagaibraesch M and Andrell J and Zhang Z and Xue Y and Wenzel EV and Calzolai L and Varani L and Rezaei N and Chavoshzadeh Z and Baldanti F and Hust M and Hammarstrom L and Marcotte H and Panhammarstrom Q}, title = {Heterologous Immunization With Inactivated Vaccine Followed by Mrna-Booster Elicits Strong Immunity Against Sars-Cov-2 Omicron Variant}, journal = {Nature Communications}, volume = {13}, number = {1}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Zuo F AU - Abolhassani H AU - Du L AU - Piralla A AU - Bertoglio F AU - De Camposmata L AU - Wan H AU - Schubert M AU - Cassaniti I AU - Wang Y AU - Sammartino JC AU - Sun R AU - Vlachiotis S AU - Bergami F AU - Kumagaibraesch M AU - Andrell J AU - Zhang Z AU - Xue Y AU - Wenzel EV AU - Calzolai L AU - Varani L AU - Rezaei N AU - Chavoshzadeh Z AU - Baldanti F AU - Hust M AU - Hammarstrom L AU - Marcotte H AU - Panhammarstrom Q TI - Heterologous Immunization With Inactivated Vaccine Followed by Mrna-Booster Elicits Strong Immunity Against Sars-Cov-2 Omicron Variant JO - Nature Communications VL - 13 IS - 1 SP - EP - PY - 2022 ER -

Style

Citing Format

MLA

Zuo F, et al.. "Heterologous Immunization With Inactivated Vaccine Followed by Mrna-Booster Elicits Strong Immunity Against Sars-Cov-2 Omicron Variant." Nature Communications, vol. 13, no. 1, 2022, pp. -.

APA

Zuo F, Abolhassani H, Du L, Piralla A, Bertoglio F, De Camposmata L, Wan H, Schubert M, Cassaniti I, Wang Y, Sammartino JC, Sun R, Vlachiotis S, Bergami F, Kumagaibraesch M, Andrell J, Zhang Z, Xue Y, Wenzel EV, ... Panhammarstrom Q (2022). Heterologous Immunization With Inactivated Vaccine Followed by Mrna-Booster Elicits Strong Immunity Against Sars-Cov-2 Omicron Variant. Nature Communications, 13(1), -.

Chicago

Zuo F, Abolhassani H, Du L, Piralla A, Bertoglio F, De Camposmata L, Wan H, et al.. "Heterologous Immunization With Inactivated Vaccine Followed by Mrna-Booster Elicits Strong Immunity Against Sars-Cov-2 Omicron Variant." Nature Communications 13, no. 1 (2022): -.

Harvard

Zuo F et al. (2022) 'Heterologous Immunization With Inactivated Vaccine Followed by Mrna-Booster Elicits Strong Immunity Against Sars-Cov-2 Omicron Variant', Nature Communications, 13(1), pp. -.

Vancouver

Zuo F, Abolhassani H, Du L, Piralla A, Bertoglio F, De Camposmata L, et al.. Heterologous Immunization With Inactivated Vaccine Followed by Mrna-Booster Elicits Strong Immunity Against Sars-Cov-2 Omicron Variant. Nature Communications. 2022;13(1):-.

BibTex

@article{ author = {Zuo F and Abolhassani H and Du L and Piralla A and Bertoglio F and De Camposmata L and Wan H and Schubert M and Cassaniti I and Wang Y and Sammartino JC and Sun R and Vlachiotis S and Bergami F and Kumagaibraesch M and Andrell J and Zhang Z and Xue Y and Wenzel EV and Calzolai L and Varani L and Rezaei N and Chavoshzadeh Z and Baldanti F and Hust M and Hammarstrom L and Marcotte H and Panhammarstrom Q}, title = {Heterologous Immunization With Inactivated Vaccine Followed by Mrna-Booster Elicits Strong Immunity Against Sars-Cov-2 Omicron Variant}, journal = {Nature Communications}, volume = {13}, number = {1}, pages = {-}, year = {2022} }

RIS

TY - JOUR
AU - Zuo F
AU - Abolhassani H
AU - Du L
AU - Piralla A
AU - Bertoglio F
AU - De Camposmata L
AU - Wan H
AU - Schubert M
AU - Cassaniti I
AU - Wang Y
AU - Sammartino JC
AU - Sun R
AU - Vlachiotis S
AU - Bergami F
AU - Kumagaibraesch M
AU - Andrell J
AU - Zhang Z
AU - Xue Y
AU - Wenzel EV
AU - Calzolai L
AU - Varani L
AU - Rezaei N
AU - Chavoshzadeh Z
AU - Baldanti F
AU - Hust M
AU - Hammarstrom L
AU - Marcotte H
AU - Panhammarstrom Q
TI - Heterologous Immunization With Inactivated Vaccine Followed by Mrna-Booster Elicits Strong Immunity Against Sars-Cov-2 Omicron Variant
JO - Nature Communications
VL - 13
IS - 1
SP -
EP -
PY - 2022
ER -

Science Communicator Platform

Authors

Abstract