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Expression Analysis of Dusp6, Dab2ip, and Rkip Genes in Patients With Head and Neck Squamous Cell Carcinoma Publisher



Rezaei Z1 ; Shakoori A1, 2 ; Karimi E3 ; Mokhtari Z3 ; Saffarzadeh N1 ; Nazari T1 ; Ahmadi M4 ; Bazzaz JT1
Authors
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Authors Affiliations
  1. 1. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Genetics, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Iran
  4. 4. Booali Medical Research Center, Qom, Iran

Source: Meta Gene Published:2020


Abstract

Background: Head and neck squamous cell carcinoma (HNSCC) is recognized as one of the most common malignancies worldwide, representing high mortality and morbidity. Here, we attempted to study the expression levels of DUSP6, DAB2IP, and RKIP genes, as the critical hallmarks involved in various central mechanisms including Mitogen-activated protein kinases (MAPK) pathway, in patients with HNSCC. Methods: The mRNA expression levels of mentioned genes were evaluated in 45 HNSCC tissues and normal adjacent samples by quantitative Real-time PCR. Samples were obtained from AmirAlam Hospital Complex in Tehran, Iran. We, also, examined the correlation coefficient and receiver operating characteristic (ROC) curve for our data. Results: The expression levels of DUSP6 and DAB2IP genes were significantly up-regulated and decreased, respectively, in HNSCC samples, compared with control (p <.05). However, RKIP expression levels did not differ between these two groups. Moreover, statistically significant correlations were observed between expression levels of these three genes, as well as considerable correlations between their expression and clinicopathological features including sex, age, smoking history, histological grade, and pathologic stage for DUSP6 and DAB2IP. Finally, ROC curve analysis depicted DAB2IP and DUSP6 genes as good predictive biomarkers with highest specificity. Discussion: Given the dysregulated mRNA expression levels of DUSP6 and DAB2IP genes, along with exhibited correlations and ROC curve analysis, the pivotal importance of studied genes and their network can be suggested in patients with HNSCC. Recognizing such molecular dysregulations in central cellular pathways can pave the road to potential therapeutic interventions and to improve medical diagnosis. © 2020 Elsevier B.V.
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