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Bioelectrocatalytic Activity of One-Dimensional Porous Pt Nanoribbons for Efficient Inhibition of Tumor Growth and Metastasis Publisher Pubmed



Molaabasi F1 ; Kefayat A1, 2 ; Sarparast M3 ; Hajipourverdom B4, 5 ; Shamsipur M3 ; Seyfoori A6 ; Moosavimovahedi AA7 ; Bahrami M8 ; Karami M9 ; Dehshiri M10
Authors
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Authors Affiliations
  1. 1. Biomaterials and Tissue Engineering Research Group, Department of Interdisciplinary Technologies, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, 1517964311, Iran
  2. 2. Department of Oncology, Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, 8174673461, Iran
  3. 3. Department of Chemistry, Razi University, Kermanshah, 6714414971, Iran
  4. 4. Integrative Oncology Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, 1517964311, Iran
  5. 5. Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, 14115111, Iran
  6. 6. Laboratory for Innovations in Micro Engineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, V8P 5C2, BC, Canada
  7. 7. Institute of Biochemistry and Biophysics, University of Tehran, Tehran, 1417614335, Iran
  8. 8. Department of Radiology, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  9. 9. Department of Dermatology, Tehran University of Medical Sciences, Tehran, 1416753955, Iran
  10. 10. Department of Nanobiotechnology, Faculty of Biological Science, Tarbiat Modares University, Tehran, 14115111, Iran

Source: ACS Applied Materials and Interfaces Published:2024


Abstract

Designing and synthesizing one-dimensional porous Pt nanocrystals with unique optical, electrocatalytic, and theranostic properties are gaining lots of attention, especially to overcome the challenges of tumor recurrence and resistance to platinum-based chemotherapy. Herein, we represented an interesting report of a one-step and facile strategy for synthesizing multifunctional one-dimensional (1D) porous Pt nanoribbons (PtNRBs) with highly efficient therapeutic effects on cancer cells based on inherent electrocatalytic activity. The critical point in the formation of luminescent porous PtNRBs was the use of human hemoglobin (Hb) as a shape-regulating, stabilizing, and reducing agent with facet-specific domains on which fluorescent platinum nanoclusters at first are aggregated by aggregation-induced emission phenomena (AIE) and then crystallized into contact and penetration twins, as intermediate products, followed by shaping of the final luminescent porous ribbon nanomaterials, owing to oriented attachment association via the Ostwald ripening mechanism. From a medical point of view, the key strategy for effective cancer therapy occured via using low-dosage ethanol in the presence of electroactive porous PtNRBs based on intracellular ethanol oxidation-mediated reactive oxygen species (ROS) generation. The role of heme groups of Hb, as electrocatalytically active centers, was successfully demonstrated in both kinetically controlled anisotropic growth of NRBs for slowing down the reduction of Pt(II) followed by oligomerization of Pt(II)-Hb complexes via platinophilic interactions as well as electrocatalytic ethanol oxidation for therapy. Interestingly, hyaluronic acid-targeted (HA) Hb-PtNRB in the presence of low-dose ethanol caused extraordinary arrest of tumor growth and metastasis with no recurrence even after the treatment course stopped, which caused elongation of tumor-bearing mice survival. HA/Hb-PtNRB was completely biocompatible and exhibited high tumor-targeting efficacy for fluorescent imaging of breast tumors. Therefore, the synergistic electrocatalytic activity of PtNRBs is presented as an efficient and safe cancer theranostic method for the first time. © 2024 American Chemical Society.
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