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Recent Advances in Porphyrin-Based Nanocomposites for Effective Targeted Imaging and Therapy Publisher Pubmed



Rabiee N1 ; Yaraki MT2, 3 ; Garakani SM4 ; Garakani SM4 ; Ahmadi S5, 6 ; Lajevardi A7 ; Bagherzadeh M1 ; Rabiee M8 ; Tayebi L9 ; Tahriri M9 ; Hamblin MR10, 11, 12
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, Sharif University of Technology, Tehran, Iran
  2. 2. Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585, Singapore
  3. 3. Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 2 Fusionopolis Way, 138634, Singapore
  4. 4. Department of Biotechnology, Payame Noor University, P.O Box, 19395-3697, Alborz, Iran
  5. 5. Student Research Committee, Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran
  8. 8. Biomaterial Group, Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran
  9. 9. Department of Developmental Sciences, Marquette University, Milwaukee, 53233, WI, United States
  10. 10. Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, United States
  11. 11. Department of Dermatology, Harvard Medical School, Boston, United States
  12. 12. Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, 2028, South Africa

Source: Biomaterials Published:2020


Abstract

Porphyrins are organic compounds that continue to attract much theoretical interest, and have been called the “pigments of life”. They have a wide role in photodynamic and sonodynamic therapy, along with uses in magnetic resonance, fluorescence and photoacoustic imaging. There is a vast range of porphyrins that have been isolated or designed, but few of them have real clinical applications. Due to the hydrophobic properties of porphyrins, and their tendency to aggregate by stacking of the planar molecules they are difficult to work with in aqueous media. Therefore encapsulating them in nanoparticles (NPs) or attachment to various delivery vehicles have been used to improve delivery characteristics. Porphyrins can be used in a composite designed material with properties that allow specific targeting, immune tolerance, extended tissue lifetime and improved hydrophilicity. Drug delivery, healing and repairing of damaged organs, and cancer theranostics are some of the medical uses of porphyrin-based nanocomposites covered in this review. Impact statement: Porphyrin nanocomposites are increasingly being used as rationally designed theranostic systems. This timely review gathers together diverse reports of these applications especially for cancer diagnosis and therapy. © 2019 Elsevier Ltd
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