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Silica Nanoparticles-Incorporated Carbon Nanofibers As Bioactive Biomaterial for Bone Tissue Engineering Publisher



Nekounam H1, 2 ; Kandi MR3 ; Shaterabadi D3 ; Samadian H4 ; Mahmoodi N5 ; Hasanzadeh E6 ; Faridimajidi R1
Authors
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Authors Affiliations
  1. 1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran
  3. 3. Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Science, Tabriz, Iran
  4. 4. Nano Drug Delivery Research Centre, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  5. 5. Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Source: Diamond and Related Materials Published:2021


Abstract

Electrospun carbon nanofibers (ECNFs) have attractive capacity in the various fields of tissue engineering. The ECNFs are electro-conductive, biocompatible and capable to mimic extracellular matrix (ECM). In this study, the different ECNFs/silica nanoparticles (ECNFs/SNPs) composites were fabricated via electrospinning method and thermal treatments. This study evaluated the effect of SNPs incorporation in the electrical conductivity, wettability and bioactivity of ECNFs. The incorporation of SNPs in the ECNFs increase the hydrophilicity of these materials but decrease the electrical conductivity of them. Moreover, the biological activity of the ECNFs such as cell attachment, viability and proliferation rate improved through the incorporation of SNPs. The ECNFs/SNPs composite show increased MG-63 proliferation rate, which is owing to the strong osteoactive behavior of this composite. The present study illustrated that ECNFs/SNPs nanocomposites exhibited a suitable osteoactivity, due to the robust synergistic effect of the silica nanoparticles. © 2021
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