Osteoconductive and Electroactive Carbon Nanofibers/Hydroxyapatite Nanocomposite Tailored for Bone Tissue Engineering: In Vitro and in Vivo Studies

Osteoconductive and Electroactive Carbon Nanofibers/Hydroxyapatite Nanocomposite Tailored for Bone Tissue Engineering: In Vitro and in Vivo Studies Publisher Pubmed

Samadian H¹ ; Mobasheri H^{2, 3} ; Azami M⁴ ; Faridimajidi R^{3, 5}

Show Affiliations

1. Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
2. Laboratory of Membrane Biophysics and Macromolecules, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
3. Institute of Biomaterials, University of Tehrand and Tehran University of Medical Sciences (IBUTUMS), Tehran, Iran
4. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Scientific Reports Published:2020

Abstract

In this study, we aimed to fabricate osteoconductive electrospun carbon nanofibers (CNFs) decorated with hydroxyapatite (HA) crystal to be used as the bone tissue engineering scaffold in the animal model. CNFs were derived from electrospun polyacrylonitrile (PAN) nanofibers via heat treatment and the carbonized nanofibers were mineralized by a biomimetic approach. The growth of HA crystals was confirmed using XRD, FTIR, and EDAX analysis techniques. The mineralization process turned the hydrophobic CNFs (WCA: 133.5° ± 0.6°) to hydrophilic CNFs/HA nanocomposite (WCA 15.3° ± 1°). The in vitro assessments revealed that the fabricated 24M-CNFs nanocomposite was biocompatible. The osteoconductive characteristics of CNFs/HA nanocomposite promoted in vivo bone formation in the rat’s femur defect site, significantly, observed by computed tomography (CT) scan images and histological evaluation. Moreover, the histomorphometric analysis showed the highest new bone formation (61.3 ± 4.2%) in the M-CNFs treated group, which was significantly higher than the negative control group (the defect without treatment) (< 0.05). To sum up, the results implied that the fabricated CNFs/HA nanocomposite could be considered as the promising bone healing material. © 2020, The Author(s).

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Experts (# of related papers)

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Reza Faridi Majidi (10)

Seyed Mahdi Rezayat Sorkhabadi (2)

Style	Citing Format
MLA	Samadian H, et al.. "Osteoconductive and Electroactive Carbon Nanofibers/Hydroxyapatite Nanocomposite Tailored for Bone Tissue Engineering: In Vitro and in Vivo Studies." Scientific Reports, vol. 10, no. 1, 2020, pp. -.
APA	Samadian H, Mobasheri H, Azami M, Faridimajidi R (2020). Osteoconductive and Electroactive Carbon Nanofibers/Hydroxyapatite Nanocomposite Tailored for Bone Tissue Engineering: In Vitro and in Vivo Studies. Scientific Reports, 10(1), -.
Chicago	Samadian H, Mobasheri H, Azami M, Faridimajidi R. "Osteoconductive and Electroactive Carbon Nanofibers/Hydroxyapatite Nanocomposite Tailored for Bone Tissue Engineering: In Vitro and in Vivo Studies." Scientific Reports 10, no. 1 (2020): -.
Harvard	Samadian H et al. (2020) 'Osteoconductive and Electroactive Carbon Nanofibers/Hydroxyapatite Nanocomposite Tailored for Bone Tissue Engineering: In Vitro and in Vivo Studies', Scientific Reports, 10(1), pp. -.
Vancouver	Samadian H, Mobasheri H, Azami M, Faridimajidi R. Osteoconductive and Electroactive Carbon Nanofibers/Hydroxyapatite Nanocomposite Tailored for Bone Tissue Engineering: In Vitro and in Vivo Studies. Scientific Reports. 2020;10(1):-.
BibTex	@article{ author = {Samadian H and Mobasheri H and Azami M and Faridimajidi R}, title = {Osteoconductive and Electroactive Carbon Nanofibers/Hydroxyapatite Nanocomposite Tailored for Bone Tissue Engineering: In Vitro and in Vivo Studies}, journal = {Scientific Reports}, volume = {10}, number = {1}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Samadian H AU - Mobasheri H AU - Azami M AU - Faridimajidi R TI - Osteoconductive and Electroactive Carbon Nanofibers/Hydroxyapatite Nanocomposite Tailored for Bone Tissue Engineering: In Vitro and in Vivo Studies JO - Scientific Reports VL - 10 IS - 1 SP - EP - PY - 2020 ER -

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