Human Mcts1-Dependent Translation of Jak2 Is Essential for Ifn-Γ Immunity to Mycobacteria

Human Mcts1-Dependent Translation of Jak2 Is Essential for Ifn-Γ Immunity to Mycobacteria Publisher Pubmed

Bohlen J^{1, 2, 3, 4} ; Zhou Q^{5, 6} ; Philippot Q^{1, 2} ; Ogishi M⁵ ; Rinchai D⁵ ; Nieminen T⁷ ; Seyedpour S^{8, 9} ; Parvaneh N^{8, 10, 11} ; Rezaei N^{8, 12} ; Yazdanpanah N^{8, 12} ; Momenilandi M^{1, 2} ; Conil C^{1, 2} ; Neehus AL^{1, 2} ; Schmidt C^{5, 13} Show All Authors

Bohlen J^{1, 2, 3, 4}
Zhou Q^{5, 6}
Philippot Q^{1, 2}
Ogishi M⁵
Rinchai D⁵
Nieminen T⁷
Seyedpour S^{8, 9}
Parvaneh N^{8, 10, 11}
Rezaei N^{8, 12}
Yazdanpanah N^{8, 12}
Momenilandi M^{1, 2}
Conil C^{1, 2}
Neehus AL^{1, 2}
Schmidt C^{5, 13}
Arangofranco CA^{1, 2, 33}
Voyer TL^{1, 2}
Khan T^{14, 15, 16}
Yang R⁵
Puchan J¹⁷
Erazo L^{1, 2}
Roiuk M^{3, 4}
Vatovec T^{1, 2, 4}
Janda Z^{1, 2, 4}
Bagaric I^{1, 2, 4}
Materna M^{1, 2}
Gervais A^{1, 2}
Li H^{1, 2}
Rosain J^{1, 2}
Peel JN⁵
Seeleuthner Y^{1, 2}
Han JE⁵
Lhonneur AS¹⁸
Moncadavelez M⁵
Martinfernandez M^{19, 20, 21, 22, 23}
Horesh ME^{19, 20, 21, 22, 23}
Kochetkov T⁵
Schmidt M²⁴
Alshehri MA²⁵
Salo E⁷
Saxen H⁷
Elghazali G²⁶
Yatim A⁵
Soudee C^{1, 2}
Sallusto F^{17, 27}
Ensser A²⁴
Marr N^{14, 15}
Zhang P⁵
Bogunovic D^{19, 20, 21, 22, 23}
Cobat A^{1, 2}
Shahrooei M^{28, 29}
Beziat V^{1, 2, 5}
Abel L^{1, 2, 5}
Wang X⁶
Boissondupuis S^{1, 2, 5}
Teleman AA^{3, 4}
Bustamante J^{1, 2, 5, 30}
Zhang Q^{1, 2, 5}
Casanova JL^{1, 2, 5, 31, 32}

Show Affiliations

1. Laboratory of Human Genetics of Infectious Diseases, INSERM UMR1163, Necker hospital for sick children, Paris, 75015, France
2. Paris Cite University, Imagine Institute, Paris, 75015, France
3. German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany
4. Heidelberg University, Heidelberg, 69120, Germany
5. St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, 10065, NY, United States
6. Children's Hospital of Fudan University, Shanghai, 201102, China
7. New Children's Hospital, Helsinki, 00290, Finland
8. Research Center for Immunodeficiencies, Tehran University of Medical Sciences, P94V+8MF, Tehran, Iran
9. Nanomedicine Research Association (NRA), Tehran, P94V+8MF, Iran
10. Department of Pediatrics, Tehran University of Medical Sciences, Tehran, P94V+8MF, Iran
11. Children's Medical Center, Tehran, P94V+8MF, Iran
12. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, 1419733151, Iran
13. Faculty of Medicine, Heinrich Heine University Dusseldorf, Dusseldorf, 40225, Germany
14. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, 8C8M+6Q, Qatar
15. Department of Immunology, Sidra Medicine, Doha, 8C8M+6Q, Qatar
16. The Jackson Laboratory, Farmington, CT, United States
17. Institute of Microbiology, ETH Zurich, Zurich, 8049, Switzerland
18. Department of Virology, Cochin Hospital, AP-HP, Paris, 75015, France
19. Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, United States
20. Precision Immunology Institute, Icahn School, New York, 10029, NY, United States
21. Mindich Child Health and Development Institute, Icahn School, New York, 10029, NY, United States
22. Department of Pediatrics, Icahn School, New York, 10029, NY, United States
23. Department of Microbiology, Icahn School, New York, 10029, NY, United States
24. University Hospital Erlangen, Institute of Clinical and Molecular Virology, Friedrich-Alexander Universitat Erlangen-Nurnberg, Erlangen, 91054, Germany
25. King Fahad Medical City, Children's Specialized Hospital, Riyadh, 12231, Saudi Arabia
26. Sheikh Khalifa Medical City- Union71, Purehealth, Abu Dhabi, United Arab Emirates, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
27. Institute for Research in Biomedicine, Universita della Svizzera Italiana, Bellinzona, 6500, Switzerland
28. Clinical and Diagnostic Immunology, KU Leuven, Leuven, 3000, Belgium
29. Dr. Shahrooei Laboratory, 22 Bahman St., Ashrafi Esfahani Blvd, Tehran, Iran
30. Study Center for Primary Immunodeficiencies, AP-HP, Necker Hospital for Sick Children, Paris, 75015, France
31. Howard Hughes Medical Institute, New York, 10032, NY, United States
32. Department of Pediatrics, Necker Hospital for Sick Children, AP-HP, Paris, 75015, France
33. Primary Immunodeficiencies Group, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellin, Colombia

Source: Cell Published:2023

Abstract

Human inherited disorders of interferon-gamma (IFN-γ) immunity underlie severe mycobacterial diseases. We report X-linked recessive MCTS1 deficiency in men with mycobacterial disease from kindreds of different ancestries (from China, Finland, Iran, and Saudi Arabia). Complete deficiency of this translation re-initiation factor impairs the translation of a subset of proteins, including the kinase JAK2 in all cell types tested, including T lymphocytes and phagocytes. JAK2 expression is sufficiently low to impair cellular responses to interleukin-23 (IL-23) and partially IL-12, but not other JAK2-dependent cytokines. Defective responses to IL-23 preferentially impair the production of IFN-γ by innate-like adaptive mucosal-associated invariant T cells (MAIT) and γδ T lymphocytes upon mycobacterial challenge. Surprisingly, the lack of MCTS1-dependent translation re-initiation and ribosome recycling seems to be otherwise physiologically redundant in these patients. These findings suggest that X-linked recessive human MCTS1 deficiency underlies isolated mycobacterial disease by impairing JAK2 translation in innate-like adaptive T lymphocytes, thereby impairing the IL-23-dependent induction of IFN-γ. © 2023 The Author(s)

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Style	Citing Format
MLA	Bohlen J, et al.. "Human Mcts1-Dependent Translation of Jak2 Is Essential for Ifn-Γ Immunity to Mycobacteria." Cell, vol. 186, no. 23, 2023, pp. 5114-5134.e27.
APA	Bohlen J, Zhou Q, Philippot Q, Ogishi M, Rinchai D, Nieminen T, Seyedpour S, Parvaneh N, Rezaei N, Yazdanpanah N, Momenilandi M, Conil C, Neehus AL, Schmidt C, Arangofranco CA, Voyer TL, Khan T, Yang R, Puchan J, ... Casanova JL (2023). Human Mcts1-Dependent Translation of Jak2 Is Essential for Ifn-Γ Immunity to Mycobacteria. Cell, 186(23), 5114-5134.e27.
Chicago	Bohlen J, Zhou Q, Philippot Q, Ogishi M, Rinchai D, Nieminen T, Seyedpour S, et al.. "Human Mcts1-Dependent Translation of Jak2 Is Essential for Ifn-Γ Immunity to Mycobacteria." Cell 186, no. 23 (2023): 5114-5134.e27.
Harvard	Bohlen J et al. (2023) 'Human Mcts1-Dependent Translation of Jak2 Is Essential for Ifn-Γ Immunity to Mycobacteria', Cell, 186(23), pp. 5114-5134.e27.
Vancouver	Bohlen J, Zhou Q, Philippot Q, Ogishi M, Rinchai D, Nieminen T, et al.. Human Mcts1-Dependent Translation of Jak2 Is Essential for Ifn-Γ Immunity to Mycobacteria. Cell. 2023;186(23):5114-5134.e27.
BibTex	@article{ author = {Bohlen J and Zhou Q and Philippot Q and Ogishi M and Rinchai D and Nieminen T and Seyedpour S and Parvaneh N and Rezaei N and Yazdanpanah N and Momenilandi M and Conil C and Neehus AL and Schmidt C and Arangofranco CA and Voyer TL and Khan T and Yang R and Puchan J and Erazo L and Roiuk M and Vatovec T and Janda Z and Bagaric I and Materna M and Gervais A and Li H and Rosain J and Peel JN and Seeleuthner Y and Han JE and Lhonneur AS and Moncadavelez M and Martinfernandez M and Horesh ME and Kochetkov T and Schmidt M and Alshehri MA and Salo E and Saxen H and Elghazali G and Yatim A and Soudee C and Sallusto F and Ensser A and Marr N and Zhang P and Bogunovic D and Cobat A and Shahrooei M and Beziat V and Abel L and Wang X and Boissondupuis S and Teleman AA and Bustamante J and Zhang Q and Casanova JL}, title = {Human Mcts1-Dependent Translation of Jak2 Is Essential for Ifn-Γ Immunity to Mycobacteria}, journal = {Cell}, volume = {186}, number = {23}, pages = {5114-5134.e27}, year = {2023} }
RIS	TY - JOUR AU - Bohlen J AU - Zhou Q AU - Philippot Q AU - Ogishi M AU - Rinchai D AU - Nieminen T AU - Seyedpour S AU - Parvaneh N AU - Rezaei N AU - Yazdanpanah N AU - Momenilandi M AU - Conil C AU - Neehus AL AU - Schmidt C AU - Arangofranco CA AU - Voyer TL AU - Khan T AU - Yang R AU - Puchan J AU - Erazo L AU - Roiuk M AU - Vatovec T AU - Janda Z AU - Bagaric I AU - Materna M AU - Gervais A AU - Li H AU - Rosain J AU - Peel JN AU - Seeleuthner Y AU - Han JE AU - Lhonneur AS AU - Moncadavelez M AU - Martinfernandez M AU - Horesh ME AU - Kochetkov T AU - Schmidt M AU - Alshehri MA AU - Salo E AU - Saxen H AU - Elghazali G AU - Yatim A AU - Soudee C AU - Sallusto F AU - Ensser A AU - Marr N AU - Zhang P AU - Bogunovic D AU - Cobat A AU - Shahrooei M AU - Beziat V AU - Abel L AU - Wang X AU - Boissondupuis S AU - Teleman AA AU - Bustamante J AU - Zhang Q AU - Casanova JL TI - Human Mcts1-Dependent Translation of Jak2 Is Essential for Ifn-Γ Immunity to Mycobacteria JO - Cell VL - 186 IS - 23 SP - 5114 EP - 5134.e27 PY - 2023 ER -

Style

Citing Format

MLA

Bohlen J, et al.. "Human Mcts1-Dependent Translation of Jak2 Is Essential for Ifn-Γ Immunity to Mycobacteria." Cell, vol. 186, no. 23, 2023, pp. 5114-5134.e27.

APA

Bohlen J, Zhou Q, Philippot Q, Ogishi M, Rinchai D, Nieminen T, Seyedpour S, Parvaneh N, Rezaei N, Yazdanpanah N, Momenilandi M, Conil C, Neehus AL, Schmidt C, Arangofranco CA, Voyer TL, Khan T, Yang R, Puchan J, ... Casanova JL (2023). Human Mcts1-Dependent Translation of Jak2 Is Essential for Ifn-Γ Immunity to Mycobacteria. Cell, 186(23), 5114-5134.e27.

Chicago

Bohlen J, Zhou Q, Philippot Q, Ogishi M, Rinchai D, Nieminen T, Seyedpour S, et al.. "Human Mcts1-Dependent Translation of Jak2 Is Essential for Ifn-Γ Immunity to Mycobacteria." Cell 186, no. 23 (2023): 5114-5134.e27.

Harvard

Bohlen J et al. (2023) 'Human Mcts1-Dependent Translation of Jak2 Is Essential for Ifn-Γ Immunity to Mycobacteria', Cell, 186(23), pp. 5114-5134.e27.

Vancouver

Bohlen J, Zhou Q, Philippot Q, Ogishi M, Rinchai D, Nieminen T, et al.. Human Mcts1-Dependent Translation of Jak2 Is Essential for Ifn-Γ Immunity to Mycobacteria. Cell. 2023;186(23):5114-5134.e27.

BibTex

@article{ author = {Bohlen J and Zhou Q and Philippot Q and Ogishi M and Rinchai D and Nieminen T and Seyedpour S and Parvaneh N and Rezaei N and Yazdanpanah N and Momenilandi M and Conil C and Neehus AL and Schmidt C and Arangofranco CA and Voyer TL and Khan T and Yang R and Puchan J and Erazo L and Roiuk M and Vatovec T and Janda Z and Bagaric I and Materna M and Gervais A and Li H and Rosain J and Peel JN and Seeleuthner Y and Han JE and Lhonneur AS and Moncadavelez M and Martinfernandez M and Horesh ME and Kochetkov T and Schmidt M and Alshehri MA and Salo E and Saxen H and Elghazali G and Yatim A and Soudee C and Sallusto F and Ensser A and Marr N and Zhang P and Bogunovic D and Cobat A and Shahrooei M and Beziat V and Abel L and Wang X and Boissondupuis S and Teleman AA and Bustamante J and Zhang Q and Casanova JL}, title = {Human Mcts1-Dependent Translation of Jak2 Is Essential for Ifn-Γ Immunity to Mycobacteria}, journal = {Cell}, volume = {186}, number = {23}, pages = {5114-5134.e27}, year = {2023} }

RIS

TY - JOUR
AU - Bohlen J
AU - Zhou Q
AU - Philippot Q
AU - Ogishi M
AU - Rinchai D
AU - Nieminen T
AU - Seyedpour S
AU - Parvaneh N
AU - Rezaei N
AU - Yazdanpanah N
AU - Momenilandi M
AU - Conil C
AU - Neehus AL
AU - Schmidt C
AU - Arangofranco CA
AU - Voyer TL
AU - Khan T
AU - Yang R
AU - Puchan J
AU - Erazo L
AU - Roiuk M
AU - Vatovec T
AU - Janda Z
AU - Bagaric I
AU - Materna M
AU - Gervais A
AU - Li H
AU - Rosain J
AU - Peel JN
AU - Seeleuthner Y
AU - Han JE
AU - Lhonneur AS
AU - Moncadavelez M
AU - Martinfernandez M
AU - Horesh ME
AU - Kochetkov T
AU - Schmidt M
AU - Alshehri MA
AU - Salo E
AU - Saxen H
AU - Elghazali G
AU - Yatim A
AU - Soudee C
AU - Sallusto F
AU - Ensser A
AU - Marr N
AU - Zhang P
AU - Bogunovic D
AU - Cobat A
AU - Shahrooei M
AU - Beziat V
AU - Abel L
AU - Wang X
AU - Boissondupuis S
AU - Teleman AA
AU - Bustamante J
AU - Zhang Q
AU - Casanova JL
TI - Human Mcts1-Dependent Translation of Jak2 Is Essential for Ifn-Γ Immunity to Mycobacteria
JO - Cell
VL - 186
IS - 23
SP - 5114
EP - 5134.e27
PY - 2023
ER -

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