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Population-Based Pattern of Medication Use and Prevalence of Polypharmacy Among Patients With Cardiovascular Diseases: Results of the Pars Cohort Study From Iran Publisher Pubmed



Mohsenzadeh P1 ; Ardekani A2 ; Poustchi H3 ; Mohammadi Z3 ; Abdipour Mehrian SR1, 2 ; Bazrafshan Drissi H4 ; Rahimian Z5 ; Taherifard E1 ; Nabavizadeh A5 ; Kamalipour A6 ; Mesgarpour B7 ; Malekzadeh F8 ; Molavi Vardanjani H9
Authors
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Authors Affiliations
  1. 1. MPH Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran
  3. 3. Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Cardiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
  6. 6. Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, CA, United States
  7. 7. Vice Chancellery for Research and Technology, National Institute for Medical Research and Development (NIMAD), Tehran, Iran
  8. 8. Digestive Diseases Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. MPH Department, School of Medicine, Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Source: BMC Cardiovascular Disorders Published:2022


Abstract

Background: Polypharmacy in patients with cardiovascular diseases (CVDs) has been linked to several adverse outcomes. This study aimed to investigate the pattern of medication use and prevalence of polypharmacy among CVDs patients in Iran. Method: We used the baseline data of the Pars cohort study (PCS). The participants were asked to bring their medication bags; then, the medications were classified using the Anatomical Therapeutic Chemical classification. Polypharmacy was defined as using five or more medications concurrently. Poisson regression modeling was applied. The adjusted prevalence ratios (PR) and its 95% confidence interval (CI) were estimated. Results: Totally, 9262 participants were enrolled in the PCS, of whom 961 had CVDs. The prevalence of polypharmacy in participants with and without CVDs was 38.9% and 7.1%, respectively. The highest prevalence of polypharmacy (51.5%) was among obese patients. Abnormal waist-hip ratio (PR: 2.79; 95% CI 1.57–4.94), high socioeconomic status (PR: 1.65; 95% CI 1.07–2.54), tobacco-smoking (PR: 1.35; 95% CI 1.00–1.81), patients with more than three co-morbidities (PR: 1.41; 95% CI 1.30–1.53), high physical activity (PR: 0.66; 95% CI 0.45–0.95), use of opiate ever (PR: 0.46; 95% CI 0.26–0.82), and healthy overweight subjects (PR: 0.22; 95% CI 0.12–0.39) were associated with polypharmacy. Cardiovascular drugs (76.1%), drugs acting on blood and blood-forming organs (50.4%), and alimentary tract and metabolism drugs (33.9%) were the most frequently used drugs. Agents acting on the renin-angiotensin system were the mostly used cardiovascular system drugs among men and those above 60 years old, while beta-blocking agents were mostly prevalent among cardiovascular system drugs in women with CVDs. Conclusion: Given the high prevalence of polypharmacy among CVDs patients, and subsequent complications, programs to educate both physicians and patients to prevent this issue is crucial. © 2022, The Author(s).
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