Cigarette Smoke-Induced Toxicity Consequences of Intracellular Iron Dysregulation and Ferroptosis

Cigarette Smoke-Induced Toxicity Consequences of Intracellular Iron Dysregulation and Ferroptosis Publisher Pubmed

Sepand MR¹ ; Maghsoudi AS² ; Shadboorestan A³ ; Mirnia K⁴ ; Aghsami M⁵ ; Raoufi M^{1, 6}

Source: Life Sciences Published:2021

Abstract

Despite numerous studies on the mechanisms of cigarette smoking toxicity over the past three decades, some aspects remain obscure. Recent developments have drawn attention to some hopeful indicators that allow us to advance our awareness of cigarette-induced cell death. Ferroptosis is considered a type of governed death of cells distinguished by the iron-dependent lipid hydroperoxide deposition to fatal concentrations. Ferroptosis has been linked with pathological settings such as neurodegenerative diseases, cancer, heart attack, hemorrhagic stroke, traumatic brain injury, ischemia-reperfusion injury, and renal dysfunction. This review tries to explain the causal role of ferroptosis cascade in cigarette smoke-mediated toxicity and cell death, highlighting associations on potential action mechanisms and proposing suggestions for its detoxifying and therapeutic interventions. © 2021

Style	Citing Format
MLA	Sepand MR, et al.. "Cigarette Smoke-Induced Toxicity Consequences of Intracellular Iron Dysregulation and Ferroptosis." Life Sciences, vol. 281, no. , 2021, pp. -.
APA	Sepand MR, Maghsoudi AS, Shadboorestan A, Mirnia K, Aghsami M, Raoufi M (2021). Cigarette Smoke-Induced Toxicity Consequences of Intracellular Iron Dysregulation and Ferroptosis. Life Sciences, 281(), -.
Chicago	Sepand MR, Maghsoudi AS, Shadboorestan A, Mirnia K, Aghsami M, Raoufi M. "Cigarette Smoke-Induced Toxicity Consequences of Intracellular Iron Dysregulation and Ferroptosis." Life Sciences 281, no. (2021): -.
Harvard	Sepand MR et al. (2021) 'Cigarette Smoke-Induced Toxicity Consequences of Intracellular Iron Dysregulation and Ferroptosis', Life Sciences, 281(), pp. -.
Vancouver	Sepand MR, Maghsoudi AS, Shadboorestan A, Mirnia K, Aghsami M, Raoufi M. Cigarette Smoke-Induced Toxicity Consequences of Intracellular Iron Dysregulation and Ferroptosis. Life Sciences. 2021;281():-.
BibTex	@article{ author = {Sepand MR and Maghsoudi AS and Shadboorestan A and Mirnia K and Aghsami M and Raoufi M}, title = {Cigarette Smoke-Induced Toxicity Consequences of Intracellular Iron Dysregulation and Ferroptosis}, journal = {Life Sciences}, volume = {281}, number = {}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Sepand MR AU - Maghsoudi AS AU - Shadboorestan A AU - Mirnia K AU - Aghsami M AU - Raoufi M TI - Cigarette Smoke-Induced Toxicity Consequences of Intracellular Iron Dysregulation and Ferroptosis JO - Life Sciences VL - 281 IS - SP - EP - PY - 2021 ER -

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