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Stem Cell Transplantation As a Progressing Treatment for Retinitis Pigmentosa Publisher Pubmed



Hosseini Shabanan S1 ; Seyedmirzaei H1, 2, 3 ; Barnea A4 ; Hanaei S1, 2, 3 ; Rezaei N1, 2, 3
Authors
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Authors Affiliations
  1. 1. School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  2. 2. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  3. 3. Research Center for Immunodeficiencies, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  4. 4. Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY, United States

Source: Cell and Tissue Research Published:2022


Abstract

Retinal degenerative diseases such as retinitis pigmentosa (RP) are of the major causes of vision loss in developed countries. Despite the unclear pathophysiology, treatment methods have been investigated vastly in the past decades. This review article mainly discusses the advances in application of stem cell and progenitor transplantation for retinitis pigmentosa. Stem cell sources such as mesenchymal stem cells, embryonic stem cells, induced pluripotent stem cells, neural stem cells, retinal progenitor cells, and olfactory ensheathing cells are discussed separately in addition to a brief description of two approaches for treatment of early-stage RP, including gene therapy and nutritional therapy. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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Nima Rezaei (2)
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