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Retinal Tissue Engineering: Regenerative and Drug Delivery Approaches Publisher Pubmed



Aghmiuni AI1 ; Keshel SH2, 3 ; Rahmani A4 ; Nadri S4, 5, 6 ; Sefat F7, 8 ; Lashay A9
Authors
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Authors Affiliations
  1. 1. Department of Nanobiotechnology, Pasteur Institute of Iran, Tehran, Iran
  2. 2. Medical Nanotechnology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Tissue Engineering and Applied Cell Science, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medical Nanotechnology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
  5. 5. Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
  6. 6. Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
  7. 7. Department of Biomedical and Electronics Engineering, School of Engineering, University of Bradford, Bradford, United Kingdom
  8. 8. Interdisciplinary Research Centre in Polymer Science & Technology (Polymer IRC), University of Bradford, Bradford, United Kingdom
  9. 9. Translational Ophthalmology Research Centre (TORC), Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Current Stem Cell Research and Therapy Published:2023


Abstract

In recent decades, the improvement of photoreceptor-cell transplantation has been used as an effective therapeutic approach to treat retinal degenerative diseases. In this review, the effect of different factors on the differentiation process and stem cells toward photoreceptors along with cell viability, morphology, migration, adhesion, proliferation, and differentiation efficiency is discussed. Scientists are researching to better recognize the reasons for retinal degeneration, as well as discovering novel therapeutic methods to restore lost vision. In this field, several procedures and treatments in the implantation of stem cells-derived retinal cells have been explored for clinical trials. However, the number of these clinical trials is too small to draw sound decisions about whether stem-cell therapies can offer a cure for retinal diseases. Nevertheless, future research directions have started for patients affected by retinal degeneration and promising findings have been obtained. © 2023, Bentham Science Publishers. All rights reserved.
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