Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Gorgan (Iran) Population Hla Genetics and Anthropology Publisher Pubmed



Arnaizvillena A1 ; Juarez I1 ; Joshghan H2 ; Lopeznares A1 ; Rey D1 ; Callado A1 ; Hsevilla A1 ; Rashidi F1 ; Nikbin B3 ; Amirzargar A3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Immunology, University Complutense, School of Medicine, Madrid, Spain
  2. 2. Golestan University of Medical Sciences, Golestan, Iran
  3. 3. Molecular Immunology Research Center, Medical School, Tehran University of Medical Sciences, Tehran, Iran

Source: Human Immunology Published:2020


Abstract

Gorgan (Iran) have been studied for HLA-A, -B, -C, -DRB1 and -DQB1 genes for the first time. They are Turkmen and originated in East Asia around Altai Mts; they originally spoke a Turk language classified within the Turkish-Oguz group. Peripheral blood samples were collected from Gorgan City (Iran) and HLA typed by standard methodology. HLA allele frequencies were compared with 7984 chromosomes of other World populations and it was shown existence of admixture of Siberian and Mediterranean HLA characters in this population, probably due to longlasting contact with Persians. Three new HLA extended haplotypes were found: A*01:01-B*35:01-DRB1*03:01-DQB1*02:01, A*30:01-B*13:01-DRB1*15:01-DQB1*02:01 and A*31:01-B*35:01-DRB1*15:01-DQB1*03:01. Gorgan (Iran) were most close to Chuvashians (Noth Caspian Sea, Russia) and Siberians, like Tuvinians, Mansi and Buryats in Neighbour Joining and Vista analyses. It is established a relationship of this population with Kurgan (Gorgan, Iran) archaeological mounds culture. However, their kinship with Scythians (2nd century BC) and Sarmatians (4th century AD) is obscure although both of them spoke a Persian language. © 2019 American Society for Histocompatibility and Immunogenetics