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Nonviral Sirna Delivery Systems for Pancreatic Cancer Therapy Publisher Pubmed



Aghamiri S1, 2 ; Raee P3 ; Talaei S4 ; Mohammadiyeganeh S5, 6 ; Bayat S7 ; Rezaee D6 ; Ghavidel AA6 ; Teymouri A8 ; Roshanzamiri S4 ; Farhadi S6 ; Ghanbarian H2, 6, 9
Authors
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Authors Affiliations
  1. 1. Student Research Committee, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Infectious Disease, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Department of Tissue Engineering and Applied Cell SciencesSchool of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Biotechnology and Bioengineering Published:2021


Abstract

The serious drawbacks of the conventional treatment of pancreatic ductal adenocarcinoma (PDAC) such as nonspecific toxicity and high resistance to chemo and radiation therapy, have prompted the development and application of countless small interfering RNA (siRNA)-based therapeutics. Recent advances in drug delivery systems hold great promise for improving siRNA-based therapeutics and developing a new class of drugs, known as nano-siRNA drugs. However, many fundamental questions, regarding toxicity, immunostimulation, and poor knowledge of nano-bio interactions, need to be addressed before clinical translation. In this review, we provide recent achievements in the design and development of various nonviral delivery vehicles for pancreatic cancer therapy. More importantly, codelivery of conventional anticancer drugs with siRNA as a new revolutionary pancreatic cancer combinational therapy is completely discussed. © 2021 Wiley Periodicals LLC
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