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Iodine-Catalyzed Tandem Oxidative Coupling Reaction: A One-Pot Strategy for the Synthesis of New Coumarin-Fused Pyrroles Publisher



Yahyavi H1 ; Heravi MM1 ; Mahdavi M2 ; Foroumadi A3, 4
Authors
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Authors Affiliations
  1. 1. Faculty of Chemistry and Physics, Department of Chemistry, Alzahra University, Tehran, Iran
  2. 2. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medicinal Chemistry, Faculty of Pharmacy and Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

Source: Tetrahedron Letters Published:2018


Abstract

The simple and facile strategy for the synthesis of 2,3-disubstituted-chromeno[4,3-b]pyrrole-4(1H)-ones has been established. This method describes the Kornblum oxidation reaction of acetophenones, followed by the Knoevenagle treatment of the resulted (het)arylglyoxals with active methylene compounds and consequently iodine-activated Michael type reaction with 4-amino coumarin in a one-pot manner to afford disubstituted chromeno[4,3-b]pyrrole-4(1H)-one derivatives. © 2017