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A Transition-Metal-Free Fast Track to Flavones and 3-Arylcoumarins Publisher Pubmed



Golshani M1, 2 ; Khoobi M1, 3 ; Jalalimanesh N2 ; Jafarpour F2 ; Ariafard A4, 5
Authors
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Authors Affiliations
  1. 1. Nanobiomaterials Group, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, 141761411, Iran
  2. 2. School of Chemistry, College of Science, University of Tehran, P.O. Box 14155-6455, Tehran, Iran
  3. 3. Department of Pharmaceutical Biomaterials, Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. School of Physical Sciences, University of Tasmania, Private Bag 75, Hobart, 7001, TAS, Australia
  5. 5. Department of Chemistry, Faculty of Science, Central Tehran Branch, Islamic Azad University, Shahrak Gharb, Tehran, Iran

Source: Chemical Communications Published:2017


Abstract

A highly regioselective and transition-metal free one-pot arylation of chromenones with arylboronic acids has been achieved employing K2S2O8. The procedure consists of a sequence of some reactions including an arylation/decarboxylation cascade and proceeds well in aqueous media to afford biologically interesting flavones and 3-arylcoumarins. This method exhibited excellent selectivity and functional group tolerance under mild conditions. The reaction also showed perfect efficacy for the preparation of styryl coumarins. This journal is © 2017 The Royal Society of Chemistry.