The Effect of Vitamin C on Pathological Parameters and Survival Duration of Critically Ill Coronavirus Disease 2019 Patients: A Randomized Clinical Trial

The Effect of Vitamin C on Pathological Parameters and Survival Duration of Critically Ill Coronavirus Disease 2019 Patients: A Randomized Clinical Trial Publisher Pubmed

Majidi N¹ ; Rabbani F² ; Gholami S³ ; Gholamalizadeh M⁴ ; Bourbour F⁵ ; Rastgoo S⁵ ; Hajipour A⁶ ; Shadnoosh M⁷ ; Akbari ME⁴ ; Bahar B⁸ ; Ashoori N⁵ ; Alizadeh A⁹ ; Samipoor F³ ; Moslem A¹⁰ Show All Authors

Majidi N¹
Rabbani F²
Gholami S³
Gholamalizadeh M⁴
Bourbour F⁵
Rastgoo S⁵
Hajipour A⁶
Shadnoosh M⁷
Akbari ME⁴
Bahar B⁸
Ashoori N⁵
Alizadeh A⁹
Samipoor F³
Moslem A¹⁰
Doaei S¹¹
Suzuki K¹²

Show Affiliations

1. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran
2. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3. Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran
4. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5. Department of Clinical Nutrition and Dietetics, Research Institute Shahid Beheshti University of Medical Science, Tehran, Iran
6. School of Health, Qazvin University of Medical Sciences, Qazvin, Iran
7. Department of Clinical Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
8. Nutrition Sciences and Applied Food Safety Studies, Research Centre for Global Development, School of Sport Health Sciences, University of Central Lancashire, Preston, United Kingdom
9. Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran
10. Department of Anesthesiology, Sabzevar University of Medical Sciences, Sabzevar, Iran
11. Reproductive Health Research Center, Department of Obstetrics and Gynecology, School of Medicine, Al-Zahra Hospital, Guilan University of Medical Sciences, Rasht, Iran
12. Faculty of Sport Sciences, Waseda University, Tokorozawa, Japan

Source: Frontiers in Immunology Published:2021

Abstract

Introduction: Vitamin C has been reported to have beneficial effects on patients with coronavirus disease 2019 (COVID-19). This study aimed to investigate the effect of vitamin C supplementation on pathological parameters and survival duration of critically ill patients with COVID-19. Methods: This clinical trial was conducted on 120 hospitalized critically ill patients infected with COVID-19. The intervention group (n = 31) received one capsule of 500 mg of vitamin C daily for 14 days. The control group (n = 69) received the same nutrition except for vitamin C supplements. Measurement of pathological and biochemical parameters was performed at baseline and after 2 weeks of the intervention. Results: Following 2 weeks of vitamin C supplementation, the level of serum K was significantly lower in the patients compared with the control group (3.93 vs. 4.21 mEq/L, p < 0.01). Vitamin C supplementation resulted in a higher mean survival duration compared with that of the control group (8 vs. 4 days, p < 0.01). There was a linear association between the number of days of vitamin C intake and survival duration (B = 1.66, p < 0.001). The vitamin C supplementation had no effect on blood glucose, mean arterial pressure, arterial blood gas (ABG) parameters, Glasgow Coma Scale (GCS), kidney function, cell blood count (CBC), hemoglobin (Hb), platelet (Plt), partial thromboplastin time (PTT), albumin, hematocrit (Hct), and other serum electrolytes including sodium (Na), calcium, and phosphorus (P). Conclusion: The present study demonstrated the potential of vitamin C supplementation in enhancing the survival duration of critically ill patients with COVID-19. Clinical Trial Registration: https://www.irct.ir/trial/55074, identifier IRCT20151226025699N5. Copyright © 2021 Majidi, Rabbani, Gholami, Gholamalizadeh, BourBour, Rastgoo, Hajipour, Shadnoosh, Akbari, Bahar, Ashoori, Alizadeh, Samipoor, Moslem, Doaei and Suzuki.

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Mohammadreza Salehi (2)

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Style	Citing Format
MLA	Majidi N, et al.. "The Effect of Vitamin C on Pathological Parameters and Survival Duration of Critically Ill Coronavirus Disease 2019 Patients: A Randomized Clinical Trial." Frontiers in Immunology, vol. 12, no. , 2021, pp. -.
APA	Majidi N, Rabbani F, Gholami S, Gholamalizadeh M, Bourbour F, Rastgoo S, Hajipour A, Shadnoosh M, Akbari ME, Bahar B, Ashoori N, Alizadeh A, Samipoor F, Moslem A, Doaei S, Suzuki K (2021). The Effect of Vitamin C on Pathological Parameters and Survival Duration of Critically Ill Coronavirus Disease 2019 Patients: A Randomized Clinical Trial. Frontiers in Immunology, 12(), -.
Chicago	Majidi N, Rabbani F, Gholami S, Gholamalizadeh M, Bourbour F, Rastgoo S, Hajipour A, et al.. "The Effect of Vitamin C on Pathological Parameters and Survival Duration of Critically Ill Coronavirus Disease 2019 Patients: A Randomized Clinical Trial." Frontiers in Immunology 12, no. (2021): -.
Harvard	Majidi N et al. (2021) 'The Effect of Vitamin C on Pathological Parameters and Survival Duration of Critically Ill Coronavirus Disease 2019 Patients: A Randomized Clinical Trial', Frontiers in Immunology, 12(), pp. -.
Vancouver	Majidi N, Rabbani F, Gholami S, Gholamalizadeh M, Bourbour F, Rastgoo S, et al.. The Effect of Vitamin C on Pathological Parameters and Survival Duration of Critically Ill Coronavirus Disease 2019 Patients: A Randomized Clinical Trial. Frontiers in Immunology. 2021;12():-.
BibTex	@article{ author = {Majidi N and Rabbani F and Gholami S and Gholamalizadeh M and Bourbour F and Rastgoo S and Hajipour A and Shadnoosh M and Akbari ME and Bahar B and Ashoori N and Alizadeh A and Samipoor F and Moslem A and Doaei S and Suzuki K}, title = {The Effect of Vitamin C on Pathological Parameters and Survival Duration of Critically Ill Coronavirus Disease 2019 Patients: A Randomized Clinical Trial}, journal = {Frontiers in Immunology}, volume = {12}, number = {}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Majidi N AU - Rabbani F AU - Gholami S AU - Gholamalizadeh M AU - Bourbour F AU - Rastgoo S AU - Hajipour A AU - Shadnoosh M AU - Akbari ME AU - Bahar B AU - Ashoori N AU - Alizadeh A AU - Samipoor F AU - Moslem A AU - Doaei S AU - Suzuki K TI - The Effect of Vitamin C on Pathological Parameters and Survival Duration of Critically Ill Coronavirus Disease 2019 Patients: A Randomized Clinical Trial JO - Frontiers in Immunology VL - 12 IS - SP - EP - PY - 2021 ER -

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