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Stem Cell- and Gene-Based Therapies As Potential Candidates in Alzheimer's Therapy Publisher Pubmed



Hosseini SA1 ; Mohammadi R1 ; Noruzi S1 ; Mohamadi Y2 ; Azizian M4 ; Mousavy SM5 ; Ghasemi F6 ; Hesari A6 ; Sahebkar A7, 8 ; Salarinia R1 ; Aghdam AM9 ; Mirzaei H10
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Source: Journal of Cellular Biochemistry Published:2018


Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder, which is associated with impairments of memory, thinking, language, and reasoning. Despite extensive research aiming at the treatment of AD, durable and complete remissions are rare. Hence, new therapeutic approaches are required. Among various therapeutic approaches, stem cells (ie, neural stem cells, mesenchymal stem cells, and embryonic stem cells) and delivery of protective genes such as encoding nerve growth factor, APOE, and glial cell–derived neurotrophic factor have generated promise in AD therapy. Here, we summarized a variety of effective therapeutic approaches (ie, stem cells, and genes) in AD therapy. © 2018 Wiley Periodicals, Inc.
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