Secondary Klebsiella Pneumoniae Infection in Patients With Covid-19: A Systematic Review Publisher Pubmed



Koupaei M¹ ; Asadi A² ; Mahdizade Ari M³ ; Seyyedi ZS¹ ; Mohammadi F³ ; Afifi Rad R⁴ ; Ghanavati R⁵ ; Rezaei Khozani N¹ ; Darbandi A^{3, 6} ; Masjedian Jazi F³ Show Affiliations
Source: Diagnostic Microbiology and Infectious Disease Published:2024

Abstract

This study aims to investigate the development of secondary bacterial infection and risk factors associated with it in critical COVID-19 patients, and to identify the most common pathogen groups in them. All the cohort studies were retrieved from Scopus, Google Scholar, Web of Science, and MEDLINE from the inception of COVID-19 to 2022 for the following keywords: ‘Klebsiella AND COVID-19. The most common comorbidities among the patients with COVID-19 were respiratory disease (33.62%), obesity (28.99%), and heart disease or cardiovascular disease (16.31%). We report 42.91% rate of Klebsiella spp co-infection in ICU admission patients, mostly related to K. pneumonia (26.81%), K. aerogenes (9.4%), and K. oxytoca (6.7%). The overall incidence of bacterial infection in hospitalized COVID-19 patients is estimated at 15.5% and in 32.5% of cases of co-infection patients deceased. The threat of carbapenem-resistant K. pneumoniae infections in patients with COVID-19 is imminent, therefore rational antibiotic therapy based on antibiotic sensitivity test should be implemented. © 2023 Elsevier Inc.