Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Circulating Low Density Lipoprotein (Ldl) Publisher Pubmed



Khosravi M1 ; Hosseinifard R2 ; Najafi M3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Biochemistry Department, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Biochemistry Department, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Cellular and Molecular Research Center, Biochemistry Department, Iran University of Medical Sciences, Tehran, 09155192401, Iran

Source: Hormone Molecular Biology and Clinical Investigation Published:2018


Abstract

Low-density lipoprotein (LDL) particles are known as atherogenic agents in coronary artery diseases. They modify to other electronegative forms and may be the subject for improvement of inflammatory events in vessel subendothelial spaces. The circulating LDL value is associated with the plasma PCSK-9 level. They internalize into macrophages using the lysosomal receptor-mediated pathways. LDL uptake is related to the membrane scavenger receptors, modifications of lipid and protein components of LDL particles, vesicular maturation and lipid stores of cells. Furthermore, LDL vesicular trafficking is involved with the function of some proteins such as Rab and Lamp families. These proteins also help in the transportation of free cholesterol from lysosome into the cytosol. The aggregation of lipids in the cytosol is a starting point for the formation of foam cells so that they may participate in the primary core of atherosclerosis plaques. The effects of macrophage subclasses are different in the formation and remodeling of plaques. This review is focused on the cellular and molecular events involved in cholesterol homeostasis. © 2018 Walter de Gruyter GmbH, Berlin/Boston.
Related Docs
View other Related Docs
1. The Sdldl Reduces Mrc1 Expression Level and Secretion of Histamin E in Differentiated M2-Macrophages From Patients With Coronary Artery Stenosis, Cardiovascular and Hematological Disorders - Drug Targets (2017)
2. Atf3 and Egr2 Gene Expression Levels in Sdldl-Treated Macrophages of Patients With Coronary Artery Stenosis, Journal of Laboratory Medicine (2018)
3. The Emerging Crosstalk Between Atherosclerosis-Related Micrornas and Bermuda Triangle of Foam Cells: Cholesterol Influx, Trafficking, and Efflux, Cellular Signalling (2023)
4. The Role of Inflammatory Cytokines and Tumor Associated Macrophages (Tams) in Microenvironment of Pancreatic Cancer, Cytokine and Growth Factor Reviews (2018)
5. Does Evolocumab, As a Pcsk9 Inhibitor, Ameliorate the Lipid Profile in Familial Hypercholesterolemia Patients? a Meta-Analysis of Randomized Controlled Trials, Journal of Pharmacy and Pharmaceutical Sciences (2017)
6. Modulation of Macrophage Polarization for Bone Tissue Engineering Applications, Iranian Journal of Allergy# Asthma and Immunology (2018)
7. Immune Landscape of Hepatocellular Carcinoma: From Dysregulation of the Immune Responses to the Potential Immunotherapies, Cell Biochemistry and Function (2024)
8. Potential Use of the Cholesterol Transfer Inhibitor U18666a As an Antiviral Drug for Research on Various Viral Infections, Microbial Pathogenesis (2023)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (2)
Mohammad Hassan Javanbakht (2)
Other Related Docs
9. A Review of Preclinical Experiments Toward Targeting M2 Macrophages in Prostate Cancer, Current Drug Targets (2019)
10. The Lack of Association Between Different Ldl-C Levels and Oxidized Ldl in Patients With Type 2 Diabetes, Chronic Diseases and Translational Medicine (2023)
11. Metabolic Host Response and Therapeutic Approaches to Influenza Infection, Cellular and Molecular Biology Letters (2020)
12. Tumor-Associated Macrophages and Epithelial–Mesenchymal Transition in Cancer: Nanotechnology Comes Into View, Journal of Cellular Physiology (2018)
13. Vitamin D3 Induces Gene Expression of Ox-Ldl Scavenger Receptors in Streptozotocin-Induced Diabetic Rat Aortas: New Insight Into the Role of Vitamin D in Diabetic Atherosclerosis, Reports of Biochemistry and Molecular Biology (2018)
14. Targeting Hypoxia and Hypoxia-Inducible Factor-1 in the Tumor Microenvironment for Optimal Cancer Immunotherapy, Journal of Cellular Physiology (2022)
15. Macrophage’S Role in Solid Tumors: Two Edges of a Sword, Cancer Cell International (2023)
16. Patient-Specific Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells As a Model to Study Autosomal Recessive Hypercholesterolemia, Stem Cells and Development (2021)
17. Circulating Levels of Lamp2 in Coronary Artery Disease: Association With Serum Lipid Profile, Hormone and Metabolic Research (2017)
18. Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4Th Edition)1, Autophagy (2021)
19. Mevalonate Cascade and Neurodevelopmental and Neurodegenerative Diseases: Future Targets for Therapeutic Application, Current Molecular Pharmacology (2016)
20. The Effects of All Trans Retinoic Acid, Vitamin D3 and Their Combination on Plasma Levels of Mirna-125A-5P, Mirna-34A, and Mirna-126 in an Experimental Model of Diabetes, Avicenna Journal of Phytomedicine (2022)