Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Uv Spectroscopy: A Novel Method for Determination of Degree of Substitution of Phthaloyl Group As Amine Protector in Chitosan Publisher



Hajirasouliha F2, 3 ; Omidi H4 ; Omid NJ1 ; Dorkoosh FA1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
  3. 3. Smart Materials and Surfaces Laboratory, Department of Mechanical and Construction Engineering, Faculty of Engineering and Environment, Northumbria University, Newcastle upon Tyne, NE1 8ST, United Kingdom
  4. 4. Department of Medicinal Chemistry, Faculty of Medicinal Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran

Source: Zeitschrift fur Physikalische Chemie Published:2023


Abstract

The purpose of this study is to introduce and develop a new experimental method based on UV spectroscopy for measuring the degree of substitution (DS) of phthaloyl group used for protecting amine group in chitosan, a biopolymer derived from chitin that has a wide variety of applications including drug delivery in pharmaceutical products. N-phthaloylated chitosan was synthesized and the UV absorption measurements were performed on its solutions with different DS with concentrations of 6.25, 12.5, 25, 50, and 100 μg/mL in DMSO at 295 nm. The accuracy of the method was checked with H-NMR and there was consistency between the results obtained by two methods. This suggests that the UV spectroscopy can be a potential method for the characterization of the polymer and can replace the difficult methods of analysis used for the chemical structure. © 2023 De Gruyter. All rights reserved.
Related Docs
View other Related Docs
1. In-Vitro and In-Vivo Cytotoxicity and Efficacy Evaluation of Novel Glycyl-Glycine and Alanyl-Alanine Conjugates of Chitosan and Trimethyl Chitosan Nano-Particles As Carriers for Oral Insulin Delivery, International Journal of Pharmaceutics (2018)
2. Cervical Cancer and Novel Therapeutic and Diagnostic Approaches Using Chitosan As a Carrier: A Review, Current Pharmaceutical Design (2022)
3. Chitosan-Encapsulated Lipid-Based Nanovesicles for Therapeutic Applications and Tissue Engineering: A Review, Carbohydrate Polymer Technologies and Applications (2025)
4. Chitosan-Grafted Graphene Materials for Drug Delivery in Wound Healing, Current Pharmaceutical Design (2025)
5. The Potential Role of Chitosan-Based Nanoparticles As Drug Delivery Systems in Pancreatic Cancer, IUBMB Life (2020)
6. Trimethyl Chitosan Improves Anti-Hiv Effects of Atripla As a New Nanoformulated Drug, Current HIV Research (2017)
7. The Synthesis of Pt Doped Wo3 Nanosheets and Application on Colorimetric Detection of Cysteine by Naked Eye Using Response Surface Methodology for Optimization, Environmental Research (2022)
8. Grafted Polysaccharides in Drug Delivery, Tailor-Made Polysaccharides in Drug Delivery (2022)
Experts (# of related papers)
View all Related Experts
Mohammad Ali Mansournia (2)
Seyed Mahdi Rezayat Sorkhabadi (1)
Other Related Docs
9. A New Approach to Antivenom Preparation Using Chitosan Nanoparticles Containing Echiscarinatus Venom As a Novel Antigen Delivery System, Iranian Journal of Pharmaceutical Research (2017)
10. Nanofiber Technology in the Ex Vivo Expansion of Cord Blood-Derived Hematopoietic Stem Cells, Nanomedicine: Nanotechnology# Biology# and Medicine (2018)
11. Biocidal Activity of Biodegradable Polymers, Biocidal Polymers (2019)