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Convalescent Plasma Against Covid-19: A Broad-Spectrum Therapeutic Approach for Emerging Infectious Diseases Publisher



Thijssen M1 ; Devos T2 ; Ejtahed HS3, 4 ; Aminibavilolyaee S5 ; Pourfathollah AA6 ; Pourkarim MR1, 7, 8
Authors
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Authors Affiliations
  1. 1. Laboratory for Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, 3000, Belgium
  2. 2. Department of Haematology, University Hospitals Leuven, Leuven, 3000, Belgium
  3. 3. Obesity and Eating Habits Research Centre, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, 1411413137, Iran
  4. 4. Endocrinology and Metabolism Research Centre, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, 1411413137, Iran
  5. 5. Biosafety Development Group, Cellular Sciences Department, Amgen Inc., One Amgen Center Drive, Thousand Oaks, 91320, CA, United States
  6. 6. Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, P.O. Box 14115-111, Tehran, 14117-13116, Iran
  7. 7. Health Policy Research Centre, Institute of Health, Shiraz University of Medical Sciences, P.O. Box 71348-45794, Shiraz, 71348-54794, Iran
  8. 8. Blood Transfusion Research Centre, High Institute for Research and Education in Transfusion Medicine, Tehran, 14665-1157, Iran

Source: Microorganisms Published:2020


Abstract

In the lack of an effective vaccine and antiviral treatment, convalescent plasma (CP) has been a promising therapeutic approach in past pandemics. Accumulating evidence in the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic corroborates the safety of CP therapy and preliminary data underline the potential efficacy. Recently, the Food and Drug Administration (FDA) permitted CP therapy for coronavirus disease 2019 (COVID-19) patients under the emergency use authorization, albeit additional clinical studies are still needed. The imminent threat of a second or even multiple waves of COVID-19 has compelled health authorities to delineate and calibrate a feasible preparedness algorithm for deploying CP as an immediate therapeutic intervention. The success of preparedness programs depends on the interdisciplinary actions of multiple actors in politics, science, and healthcare. In this review, we evaluate the current status of CP therapy for COVID-19 patients and address the challenges that confront the implementation of CP. Finally, we propose a pandemic preparedness framework for future waves of the COVID-19 pandemic and unknown pathogen outbreaks. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
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