Magnetic Metal–Organic Framework Based on Zinc and 5-Aminolevulinic Acid: Mr Imaging and Brain Tumor Therapy

Magnetic Metal–Organic Framework Based on Zinc and 5-Aminolevulinic Acid: Mr Imaging and Brain Tumor Therapy Publisher

Ebrahimpour A¹ ; Riahi Alam N¹ ; Abdolmaleki P² ; Hajipourverdom B² ; Tirgar F³ ; Ebrahimi T¹ ; Khoobi M^{4, 5}

Show Affiliations

1. Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
3. Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Biomaterials Group, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran
5. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Inorganic and Organometallic Polymers and Materials Published:2021

Abstract

Abstract: Theranostic metal–organic frameworks (MOFs) are promising agents for cancer therapy and diagnosis. Herein, Fe3O4@ALA-Zn MOF was prepared and evaluated as an efficient therapeutic and diagnostic agent against brain cancer. Fe3O4 nanoparticles (Fe NPs) were initially synthesized and then coated with MOF constructed with 5-aminolevulinic acid (ALA) and Zinc ions to form a core–shell nanostructure. The prepared system was characterized by FTIR, PXRD, SEM, TEM and EDX analyses confirming formation of the spherical magnetic ALA-based MOFs having average size of about 30 nm. The results of the cytotoxic assay demonstrated that Fe3O4@ALA-Zn MOFs possessed higher toxicity against C6 cancerous cells than HFF normal cells, which confirmed selective toxicity of the system. Furthermore, Fe3O4@ALA-Zn MOF showed higher transverse relaxivity value compared with the naked Fe3O4 NPs (318 vs 293 mM−1 s−1, respectively) and improved sensitivity in magnetic resonance imaging (MRI). These results indicated that the introduced magnetic MOF could simultaneously function as a selective cancer cell killing agent and T2*-weighted MRI contrast agent. Graphic Abstract: [Figure not available: see fulltext.]. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.

Style	Citing Format
MLA	Ebrahimpour A, et al.. "Magnetic Metal–Organic Framework Based on Zinc and 5-Aminolevulinic Acid: Mr Imaging and Brain Tumor Therapy." Journal of Inorganic and Organometallic Polymers and Materials, vol. 31, no. 3, 2021, pp. 1208-1216.
APA	Ebrahimpour A, Riahi Alam N, Abdolmaleki P, Hajipourverdom B, Tirgar F, Ebrahimi T, Khoobi M (2021). Magnetic Metal–Organic Framework Based on Zinc and 5-Aminolevulinic Acid: Mr Imaging and Brain Tumor Therapy. Journal of Inorganic and Organometallic Polymers and Materials, 31(3), 1208-1216.
Chicago	Ebrahimpour A, Riahi Alam N, Abdolmaleki P, Hajipourverdom B, Tirgar F, Ebrahimi T, Khoobi M. "Magnetic Metal–Organic Framework Based on Zinc and 5-Aminolevulinic Acid: Mr Imaging and Brain Tumor Therapy." Journal of Inorganic and Organometallic Polymers and Materials 31, no. 3 (2021): 1208-1216.
Harvard	Ebrahimpour A et al. (2021) 'Magnetic Metal–Organic Framework Based on Zinc and 5-Aminolevulinic Acid: Mr Imaging and Brain Tumor Therapy', Journal of Inorganic and Organometallic Polymers and Materials, 31(3), pp. 1208-1216.
Vancouver	Ebrahimpour A, Riahi Alam N, Abdolmaleki P, Hajipourverdom B, Tirgar F, Ebrahimi T, et al.. Magnetic Metal–Organic Framework Based on Zinc and 5-Aminolevulinic Acid: Mr Imaging and Brain Tumor Therapy. Journal of Inorganic and Organometallic Polymers and Materials. 2021;31(3):1208-1216.
BibTex	@article{ author = {Ebrahimpour A and Riahi Alam N and Abdolmaleki P and Hajipourverdom B and Tirgar F and Ebrahimi T and Khoobi M}, title = {Magnetic Metal–Organic Framework Based on Zinc and 5-Aminolevulinic Acid: Mr Imaging and Brain Tumor Therapy}, journal = {Journal of Inorganic and Organometallic Polymers and Materials}, volume = {31}, number = {3}, pages = {1208-1216}, year = {2021} }
RIS	TY - JOUR AU - Ebrahimpour A AU - Riahi Alam N AU - Abdolmaleki P AU - Hajipourverdom B AU - Tirgar F AU - Ebrahimi T AU - Khoobi M TI - Magnetic Metal–Organic Framework Based on Zinc and 5-Aminolevulinic Acid: Mr Imaging and Brain Tumor Therapy JO - Journal of Inorganic and Organometallic Polymers and Materials VL - 31 IS - 3 SP - 1208 EP - 1216 PY - 2021 ER -

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