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Lncrnas and Mirnas: New Targets for Resveratrol in Ovarian Cancer Research Publisher Pubmed



Chaichian S1 ; Bidgoli SA2 ; Nikfar B1 ; Moazzami B1
Authors
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Authors Affiliations
  1. 1. Pars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Islamic Azad University, Tehran Medical Sciences University, Tehran, Iran

Source: Current Medicinal Chemistry Published:2023


Abstract

Ovarian cancer (OC) is the 3rd common gynecologic cancer. Numerous proce-dures are involved in the growth of OC, like migration, angiogenesis, proliferation, apop-tosis, invasion, and metastasis. Therefore, a better knowledge of the molecular processes complicated in ovarian tumorigenesis can lead to better measures for the prevention and treatment of the disease and its diagnosis. Long non-coding RNAs (LncRNAs), a sub-class of non-coding RNAs, are much more diverse than previously thought. It is suggested that these RNAs may play a role in controlling complex cellular signaling mechanisms via binding to proteins and influencing their function. Nevertheless, our acquain-tance with the participation of LncRNAs in the pathogenesis of OC is still restricted. Es-pecially, we do not yet recognize how to pharmacologically correct the epi-mutations. Resveratrol, a natural polyphenol mostly derived from grapes, has been evaluated in many studies to find its cancer therapeutic potential. In the current paper, we aimed to review the role of resveratrol as a potential natural product on lncRNAs as novel diagnostic and therapeutic targets in OC and represent new insights for further investigations. © 2023 Bentham Science Publishers.
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