Association of Anril Expression With Coronary Artery Disease in Type 2 Diabetic Patients

Association of Anril Expression With Coronary Artery Disease in Type 2 Diabetic Patients Publisher

Rahimi E¹ ; Ahmadi A¹ ; Boroumand MA² ; Soltani BM¹ ; Behmanesh M¹

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1. Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
2. Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Cell Journal Published:2018

Abstract

Objective: ANRIL is an important antisense noncoding RNA gene in the INK4 locus (9p21.3), a hot spot region associated with multiple disorders including coronary artery disease (CAD), type 2 diabetes mellitus (T2DM) and many different types of cancer. It has been shown that its expression is dysregulated in a variety of immune-mediated diseases. CAD is a major problem in T2DM patients and the cause of almost 60% of deaths in these patients worldwide. The aim of the present study was to compare the expression level of ANRIL between T2DM patients with and without CAD. Materials and Methods: In this case-control study, we examined ANRIL expression in peripheral blood mononuclear cell samples by quantitative reverse transcription- polymerase chain reaction (RT-qPCR) in 64 T2DM patients with and without CAD (33 CAD+ and 31 CAD- patients respectively, established by coronary angiography). Results: Expression analysis revealed that ANRIL was up regulated (2.34-Fold, P=0.012) in CAD+ versus CAD-diabetic patients. Data from receiver operating characteristic (ROC) curve analysis has shown that ANRIL could act as a potential biomarker for detecting CAD in diabetic patients. Conclusion: The expression level of ANRIL is associated with presence of CAD in diabetic patients and could be considered as a potential peripheral biomarker.

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Hamid Reza Mirzaei (1)

Mohammad Ali Boroumand (1)

Style	Citing Format
MLA	Rahimi E, et al.. "Association of Anril Expression With Coronary Artery Disease in Type 2 Diabetic Patients." Cell Journal, vol. 20, no. 1, 2018, pp. 41-45.
APA	Rahimi E, Ahmadi A, Boroumand MA, Soltani BM, Behmanesh M (2018). Association of Anril Expression With Coronary Artery Disease in Type 2 Diabetic Patients. Cell Journal, 20(1), 41-45.
Chicago	Rahimi E, Ahmadi A, Boroumand MA, Soltani BM, Behmanesh M. "Association of Anril Expression With Coronary Artery Disease in Type 2 Diabetic Patients." Cell Journal 20, no. 1 (2018): 41-45.
Harvard	Rahimi E et al. (2018) 'Association of Anril Expression With Coronary Artery Disease in Type 2 Diabetic Patients', Cell Journal, 20(1), pp. 41-45.
Vancouver	Rahimi E, Ahmadi A, Boroumand MA, Soltani BM, Behmanesh M. Association of Anril Expression With Coronary Artery Disease in Type 2 Diabetic Patients. Cell Journal. 2018;20(1):41-45.
BibTex	@article{ author = {Rahimi E and Ahmadi A and Boroumand MA and Soltani BM and Behmanesh M}, title = {Association of Anril Expression With Coronary Artery Disease in Type 2 Diabetic Patients}, journal = {Cell Journal}, volume = {20}, number = {1}, pages = {41-45}, year = {2018} }
RIS	TY - JOUR AU - Rahimi E AU - Ahmadi A AU - Boroumand MA AU - Soltani BM AU - Behmanesh M TI - Association of Anril Expression With Coronary Artery Disease in Type 2 Diabetic Patients JO - Cell Journal VL - 20 IS - 1 SP - 41 EP - 45 PY - 2018 ER -

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