Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Cur-Loaded Magnetic Znfe2o4@Mzno-Ox-P-G-C3n4 Composites As Dual Ph- and Ultrasound Responsive Nano-Carriers for Controlled and Targeted Cancer Chemotherapy Publisher



Rostami M1 ; Nasab AS2, 3 ; Fasihiramandi M4 ; Badiei A1 ; Ganjali MR5, 6 ; Rahiminasrabadi M4, 7 ; Ahmadi F8, 9
Authors
Show Affiliations
Authors Affiliations
  1. 1. School of Chemistry, College of Science, University of Tehran, Tehran, Iran
  2. 2. Social Determinants of Health (SDH) Research Center, Kashan University of Medical Sciences, Kashan, Iran
  3. 3. Core Research Lab, Kashan University of Medical Sciences, Kashan, Iran
  4. 4. Molecular Biology Research Center, Systems Biology and Poisoning Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
  5. 5. Center of Excellence in Electrochemistry, Faculty of Chemistry, University of Tehran, Tehran, Iran
  6. 6. Biosensor Research Center, Endocrinology & Metabolism Molecular Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran
  8. 8. Razi Drug Research Center, Iran University of Medical Sciences, Tehran, 1449614535, Iran
  9. 9. Department of Medicinal Chemistry, Faculty of Pharmacy-International Campus, Iran University of Medical Sciences, Iran

Source: Materials Chemistry and Physics Published:2021


Abstract

Curcumin (Cur)-loaded zinc ferrite-mesoporous (m) zinc oxide core–shell -oxygen functional groups (carboxyl, carbonyl and hydroxyl) rich mesoporous (p) graphitic (g) carbon nitride (ZnFe2O4@mZnO-Ox-p-g-C3N4) carriers were designed as a potential magnetic drug delivery carrier with pH and ultrasound sensitivity for targeted drug delivery. Application of focused ultrasound can be an effective stimulant for highlighting tumor tissue or activatng delivery of echogenic drugs, which is expected to lower the systemic side effects of chemotherapy. The mixed application of physical/external (ultrasound) and chemical/internal (pH) triggers can allow for targeted release of Cur at chosen sections of tumor tissue. ZnFe2O4@mZnO and ZnFe2O4@mZnO-p-g-C3N4 nano-carriers were characterized using field emission scanning electron microscopy (FESEM), energy-dispersive X-ray analysis (EDX), X-ray diffraction (XRD), Fourier rransform infra-red (FTIR) spectroscopy, dynamic light scattering (DLS), zeta potential analysis, transmission electron microscopy (TEM), BET (Brunauer–Emmett–Teller), vibrating sample magnetometery (VSM), thermogravimetric analysis (TGA) and in vitro cytotoxicity assays. The ZnFe2O4@mZnOand ZnFe2O4@mZnO-Ox-p-g-C3N4 magnetic nano-carriers showed high loading efficiency of 51.39 and 67.37%, respectively, were stable in water for 24 h. The carriers Nano-carriersshowed pH- and ultrasound-sesnsitive release of Cur. The release at pH = 5.5 for (ZnFe2O4@mZnO 70.28%) (ZnFe2O4@mZnO-Ox-p-g-C3N4 56.05%) was more than that at pH = 7.4 for (ZnFe2O4@mZnO 66.26%) (ZnFe2O4@mZnO-Ox-p-g-C3N4 45.40%) after 72 h. © 2021 Elsevier B.V.
Related Docs
View other Related Docs
1. Nano-Architectural Design of Tio2 for High Performance Photocatalytic Degradation of Organic Pollutant: A Review, Environmental Research (2022)
2. Heterojunction of N/B/Rgo and G-C3n4 Anchored Magnetic Znfe2o4@Zno for Promoting Uv/Vis-Induced Photo-Catalysis and in Vitro Toxicity Studies, Environmental Science and Pollution Research (2021)
3. Cur-Loaded Magnetic Znfe2o4@L-Cysteine – Ox, N-Rich Mesoporous -Gc3n4 Nanocarriers As a Targeted Sonodynamic Chemotherapeutic Agent for Enhanced Tumor Eradication, Surfaces and Interfaces (2022)
4. Green Methods for the Preparation of Mgo Nanomaterials and Their Drug Delivery, Anti-Cancer and Anti-Bacterial Potentials: A Review, Inorganic Chemistry Communications (2022)
5. Adsorption of Cationic Dyes on a Magnetic 3D Spongin Scaffold With Nano-Sized Fe3o4 Cores, Marine Drugs (2021)
6. Sol–Gel Preparation of Metal and Nonmetal-Codoped Tio 2 –Graphene Nanophotocatalyst for Photodegradation of Mo Under Uv and Visible-Light Irradiation, Ionics (2019)
7. Synthesis of Novel Fe3o4@Sio2@Er2tio5 Superparamagnetic Core–Shell and Evaluation of Their Photocatalytic Capacity, Journal of Materials Science: Materials in Electronics (2020)
8. Simple Synthesis and Characterization of Li0.5Fe2.5O4, Limg0.5Fe2o4 and Lini0.5Fe2o4, and Investigation of Their Photocatalytic and Anticancer Properties on Hela Cells Line, Journal of Materials Science: Materials in Electronics (2019)
Other Related Docs
9. Application of Polysaccharide Biopolymers As Natural Adsorbent in Sample Preparation, Critical Reviews in Food Science and Nutrition (2023)
10. Linagliptin Electrochemical Sensor Based on Carbon Nitride-Β-Cyclodextrin Nanocomposite As a Modifier, Journal of Electroanalytical Chemistry (2020)
11. Electrochemical Determination of the Antipsychotic Medication Clozapine by a Carbon Paste Electrode Modified With a Nanostructure Prepared From Titania Nanoparticles and Copper Oxide, Microchimica Acta (2019)
12. Sonochemical Synthesis of Terbium Tungstate for Developing High Power Supercapacitors With Enhanced Energy Densities, Ultrasonics Sonochemistry (2018)
13. Synthesis and Characterization of Sm2(Moo4)3, Sm2(Moo4)3/Go and Sm2(Moo4)3/C3n4 Nanostructures for Improved Photocatalytic Performance and Their Anti-Cancer the Mcf-7 Cells, Polyhedron (2020)
14. Construction of Fe3o4/Sio2/Chitosan-Grafted-Poly(N-Vinylcaprolactam) Magnetic Nanocomposite and Their Application in Simultaneous Extraction of Trans-Resveratrol and Its Metabolites From Rat Plasma, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences (2021)
15. An Electrochemical Sensor Based on Poly (L-Cysteine)@Aunps @ Reduced Graphene Oxide Nanocomposite for Determination of Levofloxacin, Microchemical Journal (2019)
16. A Modified Sensitive Carbon Paste Electrode for 5-Fluorouracil Based Using a Composite of Praseodymium Erbium Tungstate, Microchemical Journal (2020)
17. Highly Sensitive Electrochemical Azaperone Sensor Based on Magnetic Silica –Nh2-Cs2 in the Ostrich Meat and Rat Plasma and Its Comparison With Hplc–Ms/Ms, Journal of Nanostructure in Chemistry (2023)
18. A Nanocomposite Consisting of Reduced Graphene Oxide and Electropolymerized Β-Cyclodextrin for Voltammetric Sensing of Levofloxacin, Microchimica Acta (2019)
19. A Nanocomposite Prepared From Reduced Graphene Oxide, Gold Nanoparticles and Poly(2-Amino-5-Mercapto-1,3,4-Thiadiazole) for Use in an Electrochemical Sensor for Doxorubicin, Microchimica Acta (2019)
20. Cobalt-Based Electroactive Compounds: Synthesis and Their Electrochemical and Pseudocapacitance Performance, Journal of Materials Science: Materials in Electronics (2023)
21. Preparation and Characterization of Magnetic Fe3o4/Cdwo4 and Fe3o4/Cdwo4/Prvo4 Nanoparticles and Investigation of Their Photocatalytic and Anticancer Properties on Panc1 Cells, Materials (2019)
22. Curing Epoxy With Electrochemically Synthesized Gdxfe3- Xo4 Magnetic Nanoparticles, Progress in Organic Coatings (2019)
23. Smart External Stimulus-Responsive Nanocarriers for Drug and Gene Delivery, Smart External Stimulus-Responsive Nanocarriers for Drug and Gene Delivery (2015)