Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Autophagy in Alzheimer's Disease Publisher Pubmed



Zareshahabadi A1 ; Masliah E2 ; Johnson GVW3 ; Rezaei N1, 4, 5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Molecular Immunology Research Center, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, 14194, Iran
  2. 2. Department of Neurosciences, University of California at San Diego, San Diego, 92093-0662, CA, United States
  3. 3. Department of Anesthesiology, University of Rochester, Rochester, NY, United States
  4. 4. Universal Scientific Education and Research Network (USERN), Tehran, 14194, Iran
  5. 5. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, 14194, Iran

Source: Reviews in the Neurosciences Published:2015


Abstract

Autophagy is a vesicle and lysosome-mediated degradative pathway that is essential for protein homeostasis and cell health. In particular, compared to nonneuronal cells, neurons are dependent on high basal autophagy for survival. There is emerging agreement that defects in autophagy are likely to contribute to the neurodegenerative processes in numerous diseases, including Alzheimer's disease (AD). Autophagy-lysosome defects occur early in the pathogenesis of AD and have been proposed to be a significant contributor to the disease process. Given the fact that autophagy deficits are likely major contributors to the etiology of AD, the focus of this review will be on recent studies that support a role for autophagy deficits in AD. © 2015 by De Gruyter 2015.
Related Docs
View other Related Docs
1. Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (4Th Edition)1, Autophagy (2021)
2. Targeting Mtors by Omega-3 Fatty Acids: A Possible Novel Therapeutic Strategy for Neurodegeneration?, Pharmacological Research (2018)
3. Autophagy in Cancers Including Brain Tumors: Role of Micrornas, Cell Communication and Signaling (2020)
4. Protective Role of Apelin-13 on Amyloid Β25–35-Induced Memory Deficit; Involvement of Autophagy and Apoptosis Process, Progress in Neuro-Psychopharmacology and Biological Psychiatry (2019)
5. Reversal Effects of Crocin on Amyloid Β-Induced Memory Deficit: Modification of Autophagy or Apoptosis Markers, Pharmacology Biochemistry and Behavior (2015)
6. The Potential of Targeting Autophagy-Related Non-Coding Rnas in the Treatment of Alzheimer’S and Parkinson’S Diseases, Cellular and Molecular Neurobiology (2024)
7. Highlighting the Protective or Degenerative Role of Ampk Activators in Dementia Experimental Models, CNS and Neurological Disorders - Drug Targets (2021)
8. Reduction of Autophagy Markers Mediated Protective Effects of Jnk Inhibitor and Bucladesine on Memory Deficit Induced by Aβ in Rats, Naunyn-Schmiedeberg's Archives of Pharmacology (2016)
Experts (# of related papers)
View all Related Experts
Mohammad Abdollahi (4)
Ahmad Reza Dehpour (3)
Other Related Docs
9. Exosomes, Autophagy and Er Stress Pathways in Human Diseases: Cross-Regulation and Therapeutic Approaches, Biochimica et Biophysica Acta - Molecular Basis of Disease (2022)
10. Targeting Ubiquitin-Proteasome Pathway by Natural Products: Novel Therapeutic Strategy for Treatment of Neurodegenerative Diseases, Frontiers in Physiology (2020)
11. The Effect of Insomnia on Development of Alzheimer's Disease, Journal of Neuroinflammation (2020)
12. Novel Therapeutic Strategies for Stroke: The Role of Autophagy, Critical Reviews in Clinical Laboratory Sciences (2019)
13. Autophagy, Its Mechanisms and Regulation: Implications in Neurodegenerative Diseases, Ageing Research Reviews (2017)
14. Regulation of Autophagy by Polyphenols: Paving the Road for Treatment of Neurodegeneration, Biotechnology Advances (2018)
15. Paternal Exposure to Arsenic Resulted in Oxidative Stress, Autophagy, and Mitochondrial Impairments in the Hpg-S Axis of Pubertal Male Offspring, Chemosphere (2019)
16. Lysosomal Acid Phosphatase Biosynthesis and Dysfunction: A Mini Review Focused on Lysosomal Enzyme Dysfunction in Brain, Current Molecular Medicine (2016)
17. The Role of Inflammatory Mediators in the Pathogenesis of Alzheimer’S Disease, Sultan Qaboos University Medical Journal (2015)
18. Pelargonidin Improves Memory Deficit in Amyloid Β25-35 Rat Model of Alzheimer's Disease by Inhibition of Glial Activation, Cholinesterase, and Oxidative Stress, Biomedicine and Pharmacotherapy (2016)