The Effects of Fenugreek on Controlling Glucose in Diabetes Mellitus: An Overview of Scientific Evidence

The Effects of Fenugreek on Controlling Glucose in Diabetes Mellitus: An Overview of Scientific Evidence Publisher

Ayati Z¹ ; Namazi N² ; Chang D¹

Show Affiliations

1. NICM Heath Research Institute, Western Sydney University, Westmead, Australia
2. Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Fenugreek: Traditional and Modern Medicinal Uses Published:2022

Abstract

Trigonella foenum-graecum L. (fenugreek) from Fabaceae has been used as herbal medicine to treat various disorders worldwide since antiquity. Recent evidence from preclinical and clinical studies have shown the potential of fenugreek to control hyperglycemia in diabetes mellitus. Antihyperglycaemic properties of fenugreek are mainly attributed to its bioactive constituents, mainly 4-hydroxyisoleucin, galactomannan, diosgenin and trigonelline. The potential mechanisms underlying antidiabetic activity of fenugreek and its substances are associated with β cell regeneration, increasing insulin secretion, improving the insulin-signalling pathway in adipocytes and liver cells, modulating enzymes related to glucose metabolism and inhibiting glucose resorption from the gastrointestinal tract. Given the large body of evidence, fenugreek and its bioactive constituents have a strong potential to be used as complementary medicines for controlling glucose in diabetes mellitus. This review aims to discuss the effect of fenugreek in the management of hyperglycaemia from preclinical and clinical studies and the underlying mechanisms of actions. © 2022 selection and editorial matter, Dilip Ghosh and Prasad Thakurdesai, individual chapters, the contributors.

Related Docs

1. The Effects of Fenugreek on Cardiovascular Risk Factors: What Are Potential Mechanisms?, Fenugreek: Traditional and Modern Medicinal Uses (2022)

2. Effect of Fenugreek Supplementation on Blood Lipids and Body Weight: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Journal of Ethnopharmacology (2020)

3. The Effects of Fenugreek on Cardiometabolic Risk Factors in Adults: A Systematic Review and Meta-Analysis, Complementary Therapies in Medicine (2020)

4. The Effects of Fenugreek Seed Consumption on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, High Blood Pressure and Cardiovascular Prevention (2023)

5. Comparison of the Effect of Fenugreek and Metformin on Clinical and Metabolic Status of Cases With Polycystic Ovary Syndrome: A Randomized Trial, Journal of Reproduction and Infertility (2024)

6. The Role of Natural Products As Inhibitors of Jak/Stat Signaling Pathways in Glioblastoma Treatment, Oxidative Medicine and Cellular Longevity (2022)

7. Trigonella Foenum- Graecum L., Therapeutic Medicinal Plants in Traditional Persian Medicine (2024)

Experts (# of related papers)

View all Related Experts

Nazli Namazi (2)

Mahdi Vazirian (1)

Style	Citing Format
MLA	Ayati Z, Namazi N, Chang D. "The Effects of Fenugreek on Controlling Glucose in Diabetes Mellitus: An Overview of Scientific Evidence." Fenugreek: Traditional and Modern Medicinal Uses, vol. , no. , 2022, pp. 131-150.
APA	Ayati Z, Namazi N, Chang D (2022). The Effects of Fenugreek on Controlling Glucose in Diabetes Mellitus: An Overview of Scientific Evidence. Fenugreek: Traditional and Modern Medicinal Uses, (), 131-150.
Chicago	Ayati Z, Namazi N, Chang D. "The Effects of Fenugreek on Controlling Glucose in Diabetes Mellitus: An Overview of Scientific Evidence." Fenugreek: Traditional and Modern Medicinal Uses , no. (2022): 131-150.
Harvard	Ayati Z, Namazi N, Chang D (2022) 'The Effects of Fenugreek on Controlling Glucose in Diabetes Mellitus: An Overview of Scientific Evidence', Fenugreek: Traditional and Modern Medicinal Uses, (), pp. 131-150.
Vancouver	Ayati Z, Namazi N, Chang D. The Effects of Fenugreek on Controlling Glucose in Diabetes Mellitus: An Overview of Scientific Evidence. Fenugreek: Traditional and Modern Medicinal Uses. 2022;():131-150.
BibTex	@article{ author = {Ayati Z and Namazi N and Chang D}, title = {The Effects of Fenugreek on Controlling Glucose in Diabetes Mellitus: An Overview of Scientific Evidence}, journal = {Fenugreek: Traditional and Modern Medicinal Uses}, volume = {}, number = {}, pages = {131-150}, year = {2022} }
RIS	TY - JOUR AU - Ayati Z AU - Namazi N AU - Chang D TI - The Effects of Fenugreek on Controlling Glucose in Diabetes Mellitus: An Overview of Scientific Evidence JO - Fenugreek: Traditional and Modern Medicinal Uses VL - IS - SP - 131 EP - 150 PY - 2022 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract