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Curcumin and Melanoma: From Chemistry to Medicine Publisher Pubmed



Nabavi SM1 ; Russo GL2 ; Tedesco I2 ; Daglia M3 ; Orhan IE4 ; Nabavi SF1 ; Bishayee A5 ; Nagulapalli Venkata KC5 ; Abdollahi M6 ; Hajheydari Z7
Authors
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Authors Affiliations
  1. 1. Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  2. 2. Institute of Food Sciences, National Research Council, Avellino, Italy
  3. 3. Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Pavia, Italy
  4. 4. Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara, Turkey
  5. 5. Department of Pharmaceutical Sciences, College of Pharmacy, Larkin University, Miami, FL, United States
  6. 6. Toxicology and Diseases Group, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Dermatology, Boo-Ali Sina (Avicenna) Hospital, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Source: Nutrition and Cancer Published:2018


Abstract

Melanoma is the most deadly form of skin cancer, with about 48,000 deaths each year worldwide. Growing evidence suggests that individual nutrients or dietary patterns might have important roles in the prevention of melanoma. Considering that melanoma is a potentially life-threatening cancer, novel protective and adjuvant treatments are needed to improve its prognosis. Curcumin is a bioactive substance extracted from rhizome of Curcuma longa L. Its global market is expected to grow in the next few years, especially in the pharmaceutical industry, due to its numerous physiological and pharmacological properties. For this review, we collected the available data on the protective and therapeutic role of curcumin against melanoma. We also discuss the chemistry, dietary sources, bioavailability, and metabolism of curcumin, and the mechanisms of action of its potential anticancer effects at the molecular level. Current challenges and future directions for research are also critically discussed. © 2018 Taylor & Francis Group, LLC.
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