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Myocardial Cell Signaling During the Transition to Heart Failure: Cellular Signaling and Therapeutic Approaches Publisher Pubmed



Zeglinski MR1 ; Moghadam AR2 ; Ande SR3 ; Sheikholeslami K2, 14 ; Mokarram P4 ; Sepehri Z2, 15 ; Rokni H2 ; Mohtaram NK5, 16 ; Poorebrahim M6 ; Masoom A7 ; Toback M8 ; Sareen N1 ; Saravanan S1, 13 ; Jassal DS1 Show All Authors
Authors
  1. Zeglinski MR1
  2. Moghadam AR2
  3. Ande SR3
  4. Sheikholeslami K2, 14
  5. Mokarram P4
  6. Sepehri Z2, 15
  7. Rokni H2
  8. Mohtaram NK5, 16
  9. Poorebrahim M6
  10. Masoom A7
  11. Toback M8
  12. Sareen N1
  13. Saravanan S1, 13
  14. Jassal DS1
  15. Hashemi M9
  16. Marzban H2
  17. Schaafsma D2
  18. Singal P1
  19. Wigle JT1
  20. Czubryt MP1
  21. Akbari M5
  22. Dixon IMC1
  23. Ghavami S2, 11, 12
  24. Gordon JW2, 10
  25. Dhingra S1
Show Affiliations
Authors Affiliations
  1. 1. St. Boniface Hospital Research Centre, Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada
  2. 2. Department of Human Anatomy & Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
  3. 3. Department of Internal Medicine, University of Manitoba, Winnipeg, Canada
  4. 4. Colorectal Research Center, Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Laboratory for Innovation in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC, Canada
  6. 6. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Faculty of Medicine, Mashhad Islamic Azad University, Mashhad, Iran
  8. 8. Foothills Hospital, Libin Cardiovascular Institute of Alberta, Calgary, AB, Canada
  9. 9. Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
  10. 10. College of Nursing and Children’s Hospital Research Institute of Manitoba, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
  11. 11. Biology of Breathing Theme, Children’s Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, Canada
  12. 12. Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran
  13. 13. CeNTAB, Department of Bioengineering, SCBT, SASTRA University, Thanjavur, India
  14. 14. Faculty of Medicine, University of Toronto, Toronto, ON, Canada
  15. 15. Department of Internal Medicine, Zabol University of Medical Sciences, Zabol, Iran
  16. 16. Department of System Design Engineering, University of Waterloo, Canada

Source: Comprehensive Physiology Published:2019


Abstract

Cardiovascular disease leading to heart failure (HF) remains a leading cause of morbidity and mortality worldwide. Improved pharmacological and interventional coronary procedures have led to improved outcomes following acute myocardial infarction. This success has translated into an unforeseen increased incidence in HF. This review summarizes the signaling pathways implicated in the transition to HF following cardiac injury. In addition, we provide an update on cell death signaling and discuss recent advances in cardiac fibrosis as an independent event leading to HF. Finally, we discuss cell-based therapies and their possible use to avert the deteriorating nature of HF. © 2019 American Physiological Society.
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