Multiplex H. Pylori Serology and Risk of Gastric Cardia and Noncardia Adenocarcinomas

Multiplex H. Pylori Serology and Risk of Gastric Cardia and Noncardia Adenocarcinomas Publisher Pubmed

Shakeri R¹ ; Malekzadeh R¹ ; Nasrollahzadeh D^{1, 2} ; Pawilta M³ ; Murphy G⁴ ; Islami F^{1, 5} ; Sotoudeh M¹ ; Michel A³ ; Etemadi A^{1, 4} ; Waterboer T³ ; Poustchi H⁶ ; Brennan P⁷ ; Boffetta P⁸ ; Dawsey SM⁴ Show All Authors

Shakeri R¹
Malekzadeh R¹
Nasrollahzadeh D^{1, 2}
Pawilta M³
Murphy G⁴
Islami F^{1, 5}
Sotoudeh M¹
Michel A³
Etemadi A^{1, 4}
Waterboer T³
Poustchi H⁶
Brennan P⁷
Boffetta P⁸
Dawsey SM⁴
Kamangar F^{1, 9}
Abnet CC⁴

Show Affiliations

1. Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
2. Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
3. German Cancer Research Center, Heidelberg, Germany
4. Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Bethesda, 20892, MD, United States
5. American Cancer Society, Atlanta, GA, United States
6. Digestive Diseases Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
7. International Agency for Research on Cancer, Lyon, France
8. Institute for Translational Epidemiology, Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY, United States
9. Department of Public Health Analysis, School of Community Health and Policy, Morgan State University, Baltimore, MD, United States

Source: Cancer Research Published:2015

Abstract

The reported associations with gastric adenocarcinoma and seropositivity to different Helicobacter pylori antigens using multiplex serology have not been consistent across studies. We aimed to investigate the association between 15 different multiplex serology antigens and the risk of gastric cardia (GCA) and gastric noncardia (GNCA) adenocarcinomas in northeastern Iran, a population with high rates of gastric adenocarcinoma. We included 272 cases of gastric adenocarcinoma (142 GCA, 103 GNCA, and 27 unspecified) and 524 controls who were individuallymatched to cases for age, sex, and place of residence in a population-based case-control study. Seropositivity to H. pylori was assessed using both multiplex serology and H. pylori IgG ELISA. Ninety-five percent of controls were seropositive to H. pylori. Of the 15 antibodies in the multiplex assay, 11 showed no significant association with gastric adenocarcinomas. CagA and VacA were associated with a significantly increased risk of all gastric adenocarcinoma and GNCA in multivariate models. Surprisingly, GroEL and NapA were significantly associated with a reduced risk of these tumors. Only CagA antigen was associated with significantly elevated risk of GCA. We found no associations between H. pylori seropositivity overall either by whole-cell ELISA test or multiplex serology, likely due to the high prevalence of seropositivity. Individual antigen testing showed that CagA positivity was associated with increased risk of both noncardia and cardia adenocarcinoma, which is similar to some other Asian populations, whereas two antigens were associated with lower risk of gastric cancer. This latter result was unexpected and should be retested in other populations. © 2015 AACR.

Related Docs

View other Related Docs

1. Risk of Gastric Cancer by Water Source: Evidence From the Golestan Case-Control Study, PLoS ONE (2015)

2. Multiplex Serology of Helicobacter Pylori Antigens in Detection of Current Infection and Atrophic Gastritis - a Simple and Cost-Efficient Method, Microbial Pathogenesis (2018)

3. Oral Health and Risk of Upper Gastrointestinal Cancers in a Large Prospective Study From a High-Risk Region: Golestan Cohort Study, Cancer Prevention Research (2021)

4. Mortality From Respiratory Diseases Associated With Opium Use: A Population-Based Cohort Study, Thorax (2017)

5. Pars Cohort Study of Non-Communicable Diseases in Iran: Protocol and Preliminary Results, International Journal of Public Health (2017)

6. Opium Use, Cigarette Smoking, and Alcohol Consumption in Relation to Pancreatic Cancer, Medicine (United States) (2016)

7. Individual and Combined Effects of Environmental Risk Factors for Esophageal Cancer Based on Results From the Golestan Cohort Study, Gastroenterology (2019)

8. Major Dietary Protein Sources in Relation to Pancreatic Cancer: A Large Prospective Study, Archives of Iranian Medicine (2016)

Experts (# of related papers)

View all Related Experts

Reza Malekzadeh (62)

Hossein Poustchi (52)

Style	Citing Format
MLA	Shakeri R, et al.. "Multiplex H. Pylori Serology and Risk of Gastric Cardia and Noncardia Adenocarcinomas." Cancer Research, vol. 75, no. 22, 2015, pp. 4876-4883.
APA	Shakeri R, Malekzadeh R, Nasrollahzadeh D, Pawilta M, Murphy G, Islami F, Sotoudeh M, Michel A, Etemadi A, Waterboer T, Poustchi H, Brennan P, Boffetta P, Dawsey SM, Kamangar F, Abnet CC (2015). Multiplex H. Pylori Serology and Risk of Gastric Cardia and Noncardia Adenocarcinomas. Cancer Research, 75(22), 4876-4883.
Chicago	Shakeri R, Malekzadeh R, Nasrollahzadeh D, Pawilta M, Murphy G, Islami F, Sotoudeh M, et al.. "Multiplex H. Pylori Serology and Risk of Gastric Cardia and Noncardia Adenocarcinomas." Cancer Research 75, no. 22 (2015): 4876-4883.
Harvard	Shakeri R et al. (2015) 'Multiplex H. Pylori Serology and Risk of Gastric Cardia and Noncardia Adenocarcinomas', Cancer Research, 75(22), pp. 4876-4883.
Vancouver	Shakeri R, Malekzadeh R, Nasrollahzadeh D, Pawilta M, Murphy G, Islami F, et al.. Multiplex H. Pylori Serology and Risk of Gastric Cardia and Noncardia Adenocarcinomas. Cancer Research. 2015;75(22):4876-4883.
BibTex	@article{ author = {Shakeri R and Malekzadeh R and Nasrollahzadeh D and Pawilta M and Murphy G and Islami F and Sotoudeh M and Michel A and Etemadi A and Waterboer T and Poustchi H and Brennan P and Boffetta P and Dawsey SM and Kamangar F and Abnet CC}, title = {Multiplex H. Pylori Serology and Risk of Gastric Cardia and Noncardia Adenocarcinomas}, journal = {Cancer Research}, volume = {75}, number = {22}, pages = {4876-4883}, year = {2015} }
RIS	TY - JOUR AU - Shakeri R AU - Malekzadeh R AU - Nasrollahzadeh D AU - Pawilta M AU - Murphy G AU - Islami F AU - Sotoudeh M AU - Michel A AU - Etemadi A AU - Waterboer T AU - Poustchi H AU - Brennan P AU - Boffetta P AU - Dawsey SM AU - Kamangar F AU - Abnet CC TI - Multiplex H. Pylori Serology and Risk of Gastric Cardia and Noncardia Adenocarcinomas JO - Cancer Research VL - 75 IS - 22 SP - 4876 EP - 4883 PY - 2015 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract