Photodynamic Therapy-Mediated Extirpation of Cutaneous-Resistant Dermatophytosis With Ag@Zno Nanoparticles: An Efficient Therapeutic Approach for Onychomycosis Publisher Pubmed



Ghaemi B¹ ; Hashemi SJ^{2, 3} ; Kharrazi S¹ ; Moshiri A^{4, 5} ; Kargar Jahromi H⁶ ; Amani A^{7, 8}
Source: Nanomedicine Published:2022

Abstract

Aim: The aim of this study was to determine whether photodynamic therapy of resistant onychomycosis with Ag@ZnO nanoparticles can promote the treatment procedure and extirpates the recurrence of fungal infection. Methods: Ag@ZnO nanoparticles (NPs) under UVB-radiation were applied to treat T. rubrum and T. mentagrophytes in vitro through photodynamic therapy. In vivo therapeutic efficacy, biocompatibility and biodistribution of Ag@ZnO NPs were studied. Results: 40 μg/ml of UVB-activated Ag@ZnO NPs showed 100% antifungal activity against dermatophytosis in vitro and in vivo followed by complete growth prevention by degeneration of spores and mycelium after 180 days, while posed biocompatibility. Conclusion: This study showed the superiority of photodynamic therapy with Ag@ZnO NPs followed by proper regeneration of the skin with Zinc ion of the shell. © 2022 Future Medicine Ltd.