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Photodynamic Therapy-Mediated Extirpation of Cutaneous-Resistant Dermatophytosis With Ag@Zno Nanoparticles: An Efficient Therapeutic Approach for Onychomycosis Publisher Pubmed



Ghaemi B1 ; Hashemi SJ2, 3 ; Kharrazi S1 ; Moshiri A4, 5 ; Kargar Jahromi H6 ; Amani A7, 8
Authors
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Authors Affiliations
  1. 1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences, Tehran, 1417755469, Iran
  2. 2. Department of Medical Mycology and Parasitology, School of Public Health, Tehran University of Medical Sciences, Tehran, 1417755469, Iran
  3. 3. Food Microbiology Research Centre, Tehran University of Medical Sciences, Tehran, 1417755469, Iran
  4. 4. Microbiology Research Centre, Pasteur Institute of Iran, Tehran, 1417755469, Iran
  5. 5. Laboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, Genova, Italy
  6. 6. Research Centre for Non-Communicable Disease, Jahrom University of Medical Sciences, Jahrom, Iran
  7. 7. Natural Products and Medicinal Plants Research Centre, North Khorasan University of Medical Sciences, Bojnurd, Iran
  8. 8. Medical Biomaterial Research Centre, Tehran University of Medical Sciences, Tehran, 1417755469, Iran

Source: Nanomedicine Published:2022


Abstract

Aim: The aim of this study was to determine whether photodynamic therapy of resistant onychomycosis with Ag@ZnO nanoparticles can promote the treatment procedure and extirpates the recurrence of fungal infection. Methods: Ag@ZnO nanoparticles (NPs) under UVB-radiation were applied to treat T. rubrum and T. mentagrophytes in vitro through photodynamic therapy. In vivo therapeutic efficacy, biocompatibility and biodistribution of Ag@ZnO NPs were studied. Results: 40 μg/ml of UVB-activated Ag@ZnO NPs showed 100% antifungal activity against dermatophytosis in vitro and in vivo followed by complete growth prevention by degeneration of spores and mycelium after 180 days, while posed biocompatibility. Conclusion: This study showed the superiority of photodynamic therapy with Ag@ZnO NPs followed by proper regeneration of the skin with Zinc ion of the shell. © 2022 Future Medicine Ltd.
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