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Mir-495–3P As a Promising Tumor Suppressor in Human Cancers Publisher Pubmed



Huldani H1 ; Alshahrani SH2 ; Almajidi YQ3 ; Romeroparra RM4 ; Hjazi A5 ; Alsaab HO6 ; Oudaha KH7 ; Hussien BM8 ; Ahmed M9 ; Fard SRH10
Authors
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Authors Affiliations
  1. 1. Department of Physiology, Faculty of Medicine, Lambung Mangkurat University, South Kalimantan, Banjarmasin, Indonesia
  2. 2. Medical Surgical Nursing Department, King Khalid University, Khamis Mushate, Saudi Arabia
  3. 3. Department of pharmacy (pharmaceutics), Baghdad College of Medical Sciences, Baghdad, Iraq
  4. 4. Universidad Continental, Lima, Peru
  5. 5. Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia
  6. 6. Department of Pharmaceutics and Pharmaceutical Technology, Taif University, Taif 21944, Saudi Arabia
  7. 7. Pharmaceutical Chemistry Department, College of Pharmacy, Al-Ayen University, Thi-Qar, Iraq
  8. 8. Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq
  9. 9. Medical Technical College, Al-Farahidi University, Baghdad, Iraq
  10. 10. Biochemistry Department, Tehran University of Medical Sciences, Tehran, Iran

Source: Pathology Research and Practice Published:2023


Abstract

Noncoding RNAs are a type of cellular RNA not having the ability to translate into proteins. As an important type of ncRNA with a length of about 22 nucleotides (nt), microRNAs were revealed to contribute to regulating the various cellular functions via regulating the protein translation of target genes. Among them, available studies proposed that miR-495–3p is a pivotal player in cancer pathogenesis. These studies showed that the expression level of miR-495–3p decreased in various cancer cells, suggesting its tumor suppressor role in cancer pathogenesis. Long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) are the important regulators of miR-495–3p via sponging it, leading to increased expression levels of its target genes. Moreover, miR-495–3p was shown to have a promising potential to be a prognostic and diagnostic biomarker in cancer. MiR-495–3p also could affect the resistance of cancer cells to chemotherapy agents. Here, we discussed the molecular mechanisms of miR-495–3p in various cancer including breast cancer. In addition, we discussed the miR-495–3p potential as a prognostic and diagnostic biomarker as well as its activity in cancer chemotherapy. Finally, we discussed the current limitations regarding the use of microRNAs in clinics and the future prospects of microRNAs. © 2023 Elsevier GmbH
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