Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Simultaneous Disruption of Circulating Mir-21 and Cytotoxic T Lymphocytes (Ctls): Prospective Diagnostic and Prognostic Markers for Esophageal Squamous Cell Carcinoma (Escc) Publisher Pubmed



Samiei H1 ; Ajam F2 ; Gharavi A3, 4 ; Abdolmaleki S5 ; Kokhaei P6, 7 ; Mohammadi S8, 9 ; Memarian A4, 10
Authors
Show Affiliations
Authors Affiliations
  1. 1. Immunology Department, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
  2. 2. Immunology Department, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
  3. 3. Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran
  5. 5. Clinical Immunology Laboratory, Deziani Specialized and Advanced Clinic, Golestan University of Medical Sciences, Gorgan, Iran
  6. 6. Immune and Gene Therapy Laboratory, Cancer Centre Karolinska, Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden
  7. 7. Cancer Research Center and Department of Immunology, Semnan University of Medical Sciences, Semnan, Iran
  8. 8. Stem Cell Research Center, Golestan University of Medical Sciences, Gorgan, Iran
  9. 9. Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran
  10. 10. Department of Immunology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran

Source: Journal of Clinical Laboratory Analysis Published:2022


Abstract

Background: Esophageal squamous cell carcinoma (ESCC) as the most prominent type of esophageal cancer (EC) in developing countries encompasses a substantial contribution of cancer-related mortalities and morbidities. Cytotoxic T lymphocytes (CTLs) are the major subset of effector T cells against cancer. However, the microRNAs involved in the development and regulation of CTLs could be disrupted in cancers such as EC. Methods: Here, we evaluated the population of IL-10, TGF-β, IFN-γ, and IL-17a-producing CD3+CD8+ T cells, their association with the circulating levels of miR-21 and miR-29b, and their diagnostic and/or prognostic (after 160 weeks of follow-up) utilities in 34 ESCC patients (12 newly diagnosed: ND, 24 under-treatment: UT) and 34 matched healthy donors. Results: The population of IL-10 and TGF-β-producing CTLs (CD8+ Tregs) were considerably expanded, in addition to the overexpression of miR-21 in both groups (ND and UT) of ESCC patients, while the frequency of Tc17 and CD8+ Treg cells increased only in UT patients. The expression means of TGF-β and IL-10 in CTLs were considered to be excellent biomarkers (1 ≥ area under the curve: AUC ≥0.9) in distinguishing ESCC patients and associated subgroups from healthy subjects. Moreover, the lower expressions of TGF-β, IL-17a, IL-10, and IFN-γ in CTLs were associated with ESCC better prognosis. Conclusions: The association between the impaired function of CD3+ CD8+ T cell subsets and miR-21 expression could be introduced as novel therapeutic targets and powerful diagnostic and prognostic markers for ESCC. © 2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.
Related Docs
View other Related Docs
1. Dysregulation of Helper T Lymphocytes in Esophageal Squamous Cell Carcinoma (Escc) Patients Is Highly Associated With Aberrant Production of Mir-21, Immunologic Research (2019)
2. The Paradox of Th17 Cell Functions in Tumor Immunity, Cellular Immunology (2017)
3. The Significant Role of Micrornas in Gliomas Angiogenesis: A Particular Focus on Molecular Mechanisms and Opportunities for Clinical Application, Cellular and Molecular Neurobiology (2023)
4. Circulating Micrornas As Diagnostic and Therapeutic Biomarkers in Gastric and Esophageal Cancers, Journal of Cellular Physiology (2018)
5. Tumor-Infiltrating Lymphocyte Therapy for Lung Cancer and Its Future Paradigms, Expert Opinion on Biological Therapy (2022)
6. Micrornas As Biomarkers for Early Diagnosis, Targeting and Prognosis of Prostate Cancer, Pathology Research and Practice (2023)
7. Expression of the Circulating and the Tissue Micrornas After Surgery, Chemotherapy, and Radiotherapy in Mice Mammary Tumor, Tumor Biology (2016)
8. Effects of Exercise Training and Supplementation With Selenium Nanoparticle on T-Helper 1 and 2 and Cytokine Levels in Tumor Tissue of Mice Bearing the 4 T1 Mammary Carcinoma, Nutrition (2019)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (3)
Habibollah Mahmoodzadeh (2)
Other Related Docs
9. Mrna–Mirna Bipartite Networks Reconstruction in Different Tissues of Bladder Cancer Based on Gene Co-Expression Network Analysis, Scientific Reports (2022)
10. Upregulation of Mir-371-373 Cluster, a Human Embryonic Stem Cell Specific Microrna Cluster, in Esophageal Squamous Cell Carcinoma, Journal of Cancer Research and Therapeutics (2018)
11. Overexpression of Microrna-16 Declines Cellular Growth, Proliferation and Induces Apoptosis in Human Breast Cancer Cells, In Vitro Cellular and Developmental Biology - Animal (2015)
12. An Innovative Paradigm of Methods in Micrornas Detection: Highlighting Dnazymes, the Illuminators, Biosensors and Bioelectronics (2018)
13. The Role of Oncomirs in the Pathogenesis and Treatment of Breast Cancer, Biomedicine and Pharmacotherapy (2016)
14. The Role of T Helper 17 and Regulatory T Cells in Tumor Microenvironment, Immunopharmacology and Immunotoxicology (2019)
15. Microfluidics for Detection of Exosomes and Micrornas in Cancer: State of the Art, Molecular Therapy Nucleic Acids (2022)
16. Role of Micrornas in Chronic Lymphocytic Leukemia Pathogenesis, Current Medicinal Chemistry (2020)
17. Non-Coding Rnas Are Correlated to Tgf-Β Receptor Type 2 in Patients With Colorectal Cancer, Journal of Gene Medicine (2023)
18. The Intricate Role of Mir-155 in Carcinogenesis: Potential Implications for Esophageal Cancer Research, Biomarkers in Medicine (2019)
19. Mirna-Related Polymorphisms in Mir-423 (Rs6505162) and Pex6 (Rs1129186) and Risk of Esophageal Squamous Cell Carcinoma in an Iranian Cohort, Genetic Testing and Molecular Biomarkers (2017)
20. Hurdles in Cancer Immunotherapy, Cancer Immunology: Bench to Bedside Immunotherapy of Cancers# Second Edition (2020)
21. Natural Killer Cells and Acute Myeloid Leukemia: Promises and Challenges, Cancer Immunology# Immunotherapy (2022)
22. Microrna a New Gate in Cancer and Human Disease: A Review, Journal of Biological Sciences (2017)
23. New Methods in the Diagnosis of Cancer and Gene Therapy of Cancer Based on Nanoparticles, Cancer Gene Therapy (2017)
24. Immunopathology and Immunotherapy for Breast Cancer, Cancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors (2020)