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Mutational Signatures in Esophageal Squamous Cell Carcinoma From Eight Countries With Varying Incidence Publisher Pubmed



Moody S1 ; Senkin S2 ; Islam SMA3, 4, 5 ; Wang J1 ; Nasrollahzadeh D2, 6 ; Cortez Cardoso Penha R2 ; Fitzgerald S1 ; Bergstrom EN3, 4, 5 ; Atkins J2 ; He Y3, 4, 5 ; Khandekar A3, 4, 5 ; Smithbyrne K2 ; Carreira C7 ; Gaborieau V2 Show All Authors
Authors
  1. Moody S1
  2. Senkin S2
  3. Islam SMA3, 4, 5
  4. Wang J1
  5. Nasrollahzadeh D2, 6
  6. Cortez Cardoso Penha R2
  7. Fitzgerald S1
  8. Bergstrom EN3, 4, 5
  9. Atkins J2
  10. He Y3, 4, 5
  11. Khandekar A3, 4, 5
  12. Smithbyrne K2
  13. Carreira C7
  14. Gaborieau V2
  15. Latimer C1
  16. Thomas E1
  17. Abnizova I1
  18. Bucciarelli PE1
  19. Jones D1
  20. Teague JW1
  21. Abediardekani B2
  22. Serra S8
  23. Scoazec JY9
  24. Saffar H10
  25. Azmoudehardalan F11
  26. Sotoudeh M6
  27. Nikmanesh A6
  28. Poustchi H6
  29. Niavarani A6
  30. Gharavi S6
  31. Eden M12
  32. Richman P13
  33. Campos LS14
  34. Fitzgerald RC15
  35. Ribeiro LF16
  36. Soareslima SC16
  37. Dzamalala C17
  38. Mmbaga BT18
  39. Shibata T19
  40. Menya D20
  41. Goldstein AM21
  42. Hu N21
  43. Malekzadeh R6
  44. Fazel A22
  45. Mccormack V23
  46. Mckay J2
  47. Perdomo S2
  48. Scelo G2, 24
  49. Chanudet E2
  50. Humphreys L1
  51. Alexandrov LB3, 4, 5
  52. Brennan P2
  53. Stratton MR1
Show Affiliations
Authors Affiliations
  1. 1. Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, United Kingdom
  2. 2. Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France
  3. 3. Moores Cancer Centre, UC San Diego Health, La Jolla, CA, United States
  4. 4. Department of Cellular and Molecular Medicine, University of California, La Jolla, CA, United States
  5. 5. Department of Bioengineering, University of California, La Jolla, CA, United States
  6. 6. Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Shariati Hospital, Tehran, Iran
  7. 7. Evidence Synthesis and Classification Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France
  8. 8. University Health Network, Toronto, ON, Canada
  9. 9. Department Laboratory Medicine and Pathology, Gustave Roussy, Paris, France
  10. 10. Department of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  11. 11. Liver Transplantation Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  12. 12. Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, United Kingdom
  13. 13. Histopathology Department, Hemel Hempstead General Hospital, Hemel Hempstead, United Kingdom
  14. 14. West Suffolk NHS Foundation Trust, Bury St Edmunds, United Kingdom
  15. 15. MRC Cancer Unit, University of Cambridge, Cambridge, United Kingdom
  16. 16. Brazilian National Cancer Institute, Rio de Janeiro, Brazil
  17. 17. University of Malawi, Zomba, Malawi
  18. 18. Kilimanjaro Clinical Research Institute, Kilimanjaro Christian Medical Centre & Kilimanjaro Christian Medical University College, Moshi, Tanzania
  19. 19. Division of Cancer Genomics, National Cancer Centre Research Institute, Tokyo, Japan
  20. 20. Moi University, Mombasa, Kenya
  21. 21. Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, United States
  22. 22. Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran
  23. 23. Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France
  24. 24. Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin, Turin, Italy

Source: Nature Genetics Published:2021


Abstract

Esophageal squamous cell carcinoma (ESCC) shows remarkable variation in incidence that is not fully explained by known lifestyle and environmental risk factors. It has been speculated that an unknown exogenous exposure(s) could be responsible. Here we combine the fields of mutational signature analysis with cancer epidemiology to study 552 ESCC genomes from eight countries with varying incidence rates. Mutational profiles were similar across all countries studied. Associations between specific mutational signatures and ESCC risk factors were identified for tobacco, alcohol, opium and germline variants, with modest impacts on mutation burden. We find no evidence of a mutational signature indicative of an exogenous exposure capable of explaining differences in ESCC incidence. Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like (APOBEC)-associated mutational signatures single-base substitution (SBS)2 and SBS13 were present in 88% and 91% of cases, respectively, and accounted for 25% of the mutation burden on average, indicating that APOBEC activation is a crucial step in ESCC tumor development. © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
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