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The Mutographs Biorepository: A Unique Genomic Resource to Study Cancer Around the World Publisher



Perdomo S1 ; Abediardekani B1 ; De Carvalho AC1 ; Ferreiroiglesias A1 ; Gaborieau V1 ; Cattiaux T1 ; Renard H1 ; Chopard P1 ; Carreira C2 ; Spanu A1 ; Nikmanesh A1 ; Cardoso Penha RC1 ; Antwi SO3, 4 ; Ashtonprolla P5, 6 Show All Authors
Authors
  1. Perdomo S1
  2. Abediardekani B1
  3. De Carvalho AC1
  4. Ferreiroiglesias A1
  5. Gaborieau V1
  6. Cattiaux T1
  7. Renard H1
  8. Chopard P1
  9. Carreira C2
  10. Spanu A1
  11. Nikmanesh A1
  12. Cardoso Penha RC1
  13. Antwi SO3, 4
  14. Ashtonprolla P5, 6
  15. Canova C7
  16. Chitapanarux T8
  17. Cox R9
  18. Curado MP10
  19. De Oliveira JC11
  20. Dzamalala C12
  21. Fabianova E13
  22. Ferri L14
  23. Fitzgerald R15
  24. Foretova L16
  25. Gallinger S17
  26. Goldstein AM19
  27. Holcatova I20, 21
  28. Huertas A22
  29. Janout V23
  30. Jarmalaite S24, 25
  31. Kaneva R26
  32. Kowalski LP10, 27
  33. Kulis T28, 29
  34. Lagiou P30
  35. Lissowska J31
  36. Malekzadeh R32
  37. Mates D33
  38. Mccorrmack V34
  39. Menya D35
  40. Mhatre S36
  41. Mmbaga BT37
  42. De Moricz A38
  43. Nyirady P39
  44. Ognjanovic M40
  45. Papadopoulou K41
  46. Polesel J42
  47. Purdue MP43
  48. Rascu S44
  49. Rebolho Batista LM45
  50. Reis RM45, 46
  51. Ribeiro Pinto LF47
  52. Rodriguezurrego PA48
  53. Sangkhathat S49
  54. Sangrajrang S50
  55. Shibata T51, 52
  56. Stakhovsky E53
  57. Swiatkowska B54
  58. Vaccaro C55
  59. Vasconcelos De Podesta JR56
  60. Vasudev NS57
  61. Vilensky M58
  62. Yeung J59
  63. Zaridze D60
  64. Zendehdel K61
  65. Scelo G62
  66. Chanudet E63
  67. Wang J64
  68. Fitzgerald S64
  69. Latimer C64
  70. Moody S64
  71. Humphreys L64
  72. Alexandrov LB65, 66, 67
  73. Stratton MR64
  74. Brennan P1
Show Affiliations
Authors Affiliations
  1. 1. Genomic Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France
  2. 2. Evidence Synthesis and Classification Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France
  3. 3. Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, United States
  4. 4. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Jacksonville, FL, United States
  5. 5. Experimental Research Center, Genomic Medicine Laboratory, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil
  6. 6. Post-Graduate Program in Genetics and Molecular Biology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
  7. 7. Unit of Biostatistics, Epidemiology and Public Health, Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padua, Padova, Italy
  8. 8. Department of Internal Medicine, Chiang Mai University, Chiang Mai, Thailand
  9. 9. Ontario Tumour Bank, Ontario Institute for Cancer Research, Toronto, ON, Canada
  10. 10. Department of Epidemiology, A.C. Camargo Cancer Center, Sao Paulo, Brazil
  11. 11. Associacao de Combate ao Cancer em Goias Hospital Araujo Jorge Goiania, Goiania, Brazil
  12. 12. University of Malawi College of Medicine, Blantyre, Malawi
  13. 13. Regional Authority of Public Health, Banska Bystrica, Slovakia
  14. 14. Departments of Surgery and Oncology, McGill University, Montreal, QC, Canada
  15. 15. Early Cancer Institute, University of Cambridge, Cambridge, United Kingdom
  16. 16. Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic
  17. 17. Mount Sinai Hospital
  18. 18. Ontario Institute for Cancer Research (OICR), Toronto, ON, Canada
  19. 19. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, United States
  20. 20. Institute of Public Health & Preventive Medicine, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic
  21. 21. Department of Oncology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic
  22. 22. National Cancer Institute, Bogota, Colombia
  23. 23. Faculty of Health Sciences, Palacky University, Olomouc, Czech Republic
  24. 24. Laboratory of Genetic Diagnostic, National Cancer Institute, Vilnius, Lithuania
  25. 25. Department of Botany and Genetics, Institute of Biosciences, Vilnius University, Vilnius, Lithuania
  26. 26. Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical Faculty, Medical University of Sofia, Sofia, Bulgaria
  27. 27. University of Sao Paulo Medical School, Sao Paulo, Brazil
  28. 28. Department of Urology, University Hospital Center Zagreb, Zagreb, Croatia
  29. 29. University of Zagreb School of Medicine, Zagreb, Croatia
  30. 30. National and Kapodistrian University of Athens, Athens, Greece
  31. 31. The Maria Sklodowska-Cure National Research Institute of Oncology, Warsaw, Poland
  32. 32. Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  33. 33. Occupational Health and Toxicology, National Center for Environmental Risk Monitoring, National Institute of Public Health, Bucharest, Romania
  34. 34. Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France
  35. 35. Moi University, School of Public Health, Eldoret, Kenya
  36. 36. Division of Molecular Epidemiology and Population Genomics, Centre for Cancer Epidemiology, Tata Memorial Centre, Mumbai, India
  37. 37. Department of Surgery, Santa Casa School of Medicine, Sao Paulo, Brazil
  38. 38. Kilimanjaro Clinical Research Institute, Kilimanjaro Christian Medical Centre & Kilimanjaro Christian Medical University College, Moshi, Tanzania
  39. 39. Semmelweis University, Budapest, Hungary
  40. 40. IOCPR- International Organization for Cancer Prevention and Research, Belgrade, Serbia
  41. 41. Hellenic Cooperative Oncology Group (HeCOG), Athens, Greece
  42. 42. Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy
  43. 43. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, United States
  44. 44. Urology Department, “Carol Davila� University of Medicine and Pharmacy – “Prof. Dr. Th. Burghele� Clinical Hospital, Bucharest, Romania
  45. 45. Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil
  46. 46. Life and Health Sciences Research Institute (ICVS), School of Medicine, Minho University, Braga, Portugal
  47. 47. Brazilian National Cancer Institute, Rio de Janeiro, Brazil
  48. 48. Pathology Department, Hospital Universitario Fundacion Santa Fe de Bogota, Bogota, Colombia
  49. 49. Translational Medicine Research Center, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand
  50. 50. National Cancer Institute, Bangkok, Thailand
  51. 51. Laboratory of Molecular Medicine, The Institute of Medical Science, The University of Tokyo, Minato-ku, Japan
  52. 52. Division of Cancer Genomics, National Cancer Center Research Institute, Chuo-ku, Japan
  53. 53. National Cancer Institute, Kiev, Ukraine
  54. 54. Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland
  55. 55. Instituto Medicina Traslacional e Ingenieria Biomedica - CONICET, Buenos Aires, Argentina
  56. 56. Hospital Santa Rita AFECC - Associacao Feminina de Educacao e Combate ao Cancer, Vitoria, Brazil
  57. 57. Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom
  58. 58. Instituto de Oncologia Angel Roffo, Universidad de Buenos Aires, Buenos Aires, Argentina
  59. 59. University Health Network, Toronto, ON, Canada
  60. 60. Clinical Epidemiology, N.N. Blokhin National Medical Research Centre of Oncology, Moscow, Russian Federation
  61. 61. Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
  62. 62. Observational & Pragmatic Research Institute Pte., Ltd., Singapore, Singapore
  63. 63. Department of Pathology, Radboud University Medical Centre, Nijmegen, Netherlands
  64. 64. Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Cambridge, United Kingdom
  65. 65. Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, United States
  66. 66. Department of Bioengineering, University of California San Diego, La Jolla, CA, United States
  67. 67. Moores Cancer Center, University of California San Diego, La Jolla, CA, United States

Source: Cell Genomics Published:2024


Abstract

Large-scale biorepositories and databases are essential to generate equitable, effective, and sustainable advances in cancer prevention, early detection, cancer therapy, cancer care, and surveillance. The Mutographs project has created a large genomic dataset and biorepository of over 7,800 cancer cases from 30 countries across five continents with extensive demographic, lifestyle, environmental, and clinical information. Whole-genome sequencing is being finalized for over 4,000 cases, with the primary goal of understanding the causes of cancer at eight anatomic sites. Genomic, exposure, and clinical data will be publicly available through the International Cancer Genome Consortium Accelerating Research in Genomic Oncology platform. The Mutographs sample and metadata biorepository constitutes a legacy resource for new projects and collaborations aiming to increase our current research efforts in cancer genomic epidemiology globally. © 2024
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