Exposure to Polycyclic Aromatic Hydrocarbons, Volatile Organic Compounds, and Tobacco-Specific Nitrosamines and Incidence of Esophageal Cancer

Exposure to Polycyclic Aromatic Hydrocarbons, Volatile Organic Compounds, and Tobacco-Specific Nitrosamines and Incidence of Esophageal Cancer Publisher Pubmed

Etemadi A^{1, 2} ; Poustchi H³ ; Chang CM⁴ ; Calafat AM⁵ ; Blount BC⁵ ; Bhandari D⁵ ; Wang L⁵ ; Roshandel G⁶ ; Alexandridis A⁴ ; Botelho JC⁵ ; Xia B⁵ ; Wang Y⁵ ; Sosnoff CS⁵ ; Feng J⁵ Show All Authors

Etemadi A^{1, 2}
Poustchi H³
Chang CM⁴
Calafat AM⁵
Blount BC⁵
Bhandari D⁵
Wang L⁵
Roshandel G⁶
Alexandridis A⁴
Botelho JC⁵
Xia B⁵
Wang Y⁵
Sosnoff CS⁵
Feng J⁵
Nalini M¹
Khoshnia M⁶
Pourshams A²
Sotoudeh M²
Gail MH⁷
Dawsey SM¹
Kamangar F⁸
Boffetta P^{9, 10}
Brennan P¹¹
Abnet CC¹
Malekzadeh R²
Freedman ND¹

Show Affiliations

1. Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States
2. Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
3. Liver and Pancreaticobilliary Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
4. Center for Tobacco Products, Food and Drug Administration, Silver Spring, MD, United States
5. Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, United States
6. Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran
7. Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States
8. Department of Biology, School of Computer, Mathematical and Natural Sciences, Morgan State University, Baltimore, MD, United States
9. Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY, United States
10. Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
11. International Agency for Research on Cancer, Lyon, France

Source: Journal of the National Cancer Institute Published:2024

Abstract

Background: Studying carcinogens in tobacco and nontobacco sources may be key to understanding the pathogenesis and geographic distribution of esophageal cancer. Methods: The Golestan Cohort Study has been conducted since 2004 in a region with high rates of esophageal squamous cell carcinoma. For this nested study, the cases comprised of all incident cases by January 1, 2018; controls were matched to the case by age, sex, residence, time in cohort, and tobacco use. We measured urinary concentrations of 33 exposure biomarkers of nicotine, polycyclic aromatic hydrocarbons, volatile organic compounds, and tobacco-specific nitrosamines. We used conditional logistic regression to calculate odds ratios (ORs) and 95% confidence intervals for associations between the 90th vs the 10th percentiles of the biomarker concentrations and incident esophageal squamous cell carcinoma. Results: Among individuals who did not currently use tobacco (148 cases and 163 controls), 2 acrolein metabolites, 2 acrylonitrile metabolites, 1 propylene oxide metabolite, and one 1,3-butadiene metabolite were significantly associated with incident esophageal squamous cell carcinoma (adjusted odds ratios between 1.8 and 4.3). Among tobacco users (57 cases and 63 controls), metabolites of 2 other volatile organic compounds (styrene and xylene) were associated with esophageal squamous cell carcinoma (OR ¼ 6.2 and 9.0, respectively). In tobacco users, 2 tobacco-specific nitrosamines (NNN and N’-Nitrosoanatabine) were also associated with esophageal squamous cell carcinoma. Suggestive associations were seen with some polycyclic aromatic hydrocarbons (especially 2-hydroxynaphthalene) in nonusers of tobacco products and other tobacco-specific nitrosamines in tobacco users. Conclusion: These novel associations based on individual-level data and samples collected many years before cancer diagnosis, from a population without occupational exposure, have important public health implications. © 2024 Oxford University Press. All rights reserved.

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Experts (# of related papers)

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Reza Malekzadeh (87)

Hossein Poustchi (85)

Style	Citing Format
MLA	Etemadi A, et al.. "Exposure to Polycyclic Aromatic Hydrocarbons, Volatile Organic Compounds, and Tobacco-Specific Nitrosamines and Incidence of Esophageal Cancer." Journal of the National Cancer Institute, vol. 116, no. 3, 2024, pp. 379-388.
APA	Etemadi A, Poustchi H, Chang CM, Calafat AM, Blount BC, Bhandari D, Wang L, Roshandel G, Alexandridis A, Botelho JC, Xia B, Wang Y, Sosnoff CS, Feng J, Nalini M, Khoshnia M, Pourshams A, Sotoudeh M, Gail MH, ... Freedman ND (2024). Exposure to Polycyclic Aromatic Hydrocarbons, Volatile Organic Compounds, and Tobacco-Specific Nitrosamines and Incidence of Esophageal Cancer. Journal of the National Cancer Institute, 116(3), 379-388.
Chicago	Etemadi A, Poustchi H, Chang CM, Calafat AM, Blount BC, Bhandari D, Wang L, et al.. "Exposure to Polycyclic Aromatic Hydrocarbons, Volatile Organic Compounds, and Tobacco-Specific Nitrosamines and Incidence of Esophageal Cancer." Journal of the National Cancer Institute 116, no. 3 (2024): 379-388.
Harvard	Etemadi A et al. (2024) 'Exposure to Polycyclic Aromatic Hydrocarbons, Volatile Organic Compounds, and Tobacco-Specific Nitrosamines and Incidence of Esophageal Cancer', Journal of the National Cancer Institute, 116(3), pp. 379-388.
Vancouver	Etemadi A, Poustchi H, Chang CM, Calafat AM, Blount BC, Bhandari D, et al.. Exposure to Polycyclic Aromatic Hydrocarbons, Volatile Organic Compounds, and Tobacco-Specific Nitrosamines and Incidence of Esophageal Cancer. Journal of the National Cancer Institute. 2024;116(3):379-388.
BibTex	@article{ author = {Etemadi A and Poustchi H and Chang CM and Calafat AM and Blount BC and Bhandari D and Wang L and Roshandel G and Alexandridis A and Botelho JC and Xia B and Wang Y and Sosnoff CS and Feng J and Nalini M and Khoshnia M and Pourshams A and Sotoudeh M and Gail MH and Dawsey SM and Kamangar F and Boffetta P and Brennan P and Abnet CC and Malekzadeh R and Freedman ND}, title = {Exposure to Polycyclic Aromatic Hydrocarbons, Volatile Organic Compounds, and Tobacco-Specific Nitrosamines and Incidence of Esophageal Cancer}, journal = {Journal of the National Cancer Institute}, volume = {116}, number = {3}, pages = {379-388}, year = {2024} }
RIS	TY - JOUR AU - Etemadi A AU - Poustchi H AU - Chang CM AU - Calafat AM AU - Blount BC AU - Bhandari D AU - Wang L AU - Roshandel G AU - Alexandridis A AU - Botelho JC AU - Xia B AU - Wang Y AU - Sosnoff CS AU - Feng J AU - Nalini M AU - Khoshnia M AU - Pourshams A AU - Sotoudeh M AU - Gail MH AU - Dawsey SM AU - Kamangar F AU - Boffetta P AU - Brennan P AU - Abnet CC AU - Malekzadeh R AU - Freedman ND TI - Exposure to Polycyclic Aromatic Hydrocarbons, Volatile Organic Compounds, and Tobacco-Specific Nitrosamines and Incidence of Esophageal Cancer JO - Journal of the National Cancer Institute VL - 116 IS - 3 SP - 379 EP - 388 PY - 2024 ER -

Style

Citing Format

MLA

Etemadi A, et al.. "Exposure to Polycyclic Aromatic Hydrocarbons, Volatile Organic Compounds, and Tobacco-Specific Nitrosamines and Incidence of Esophageal Cancer." Journal of the National Cancer Institute, vol. 116, no. 3, 2024, pp. 379-388.

APA

Etemadi A, Poustchi H, Chang CM, Calafat AM, Blount BC, Bhandari D, Wang L, Roshandel G, Alexandridis A, Botelho JC, Xia B, Wang Y, Sosnoff CS, Feng J, Nalini M, Khoshnia M, Pourshams A, Sotoudeh M, Gail MH, ... Freedman ND (2024). Exposure to Polycyclic Aromatic Hydrocarbons, Volatile Organic Compounds, and Tobacco-Specific Nitrosamines and Incidence of Esophageal Cancer. Journal of the National Cancer Institute, 116(3), 379-388.

Chicago

Etemadi A, Poustchi H, Chang CM, Calafat AM, Blount BC, Bhandari D, Wang L, et al.. "Exposure to Polycyclic Aromatic Hydrocarbons, Volatile Organic Compounds, and Tobacco-Specific Nitrosamines and Incidence of Esophageal Cancer." Journal of the National Cancer Institute 116, no. 3 (2024): 379-388.

Harvard

Etemadi A et al. (2024) 'Exposure to Polycyclic Aromatic Hydrocarbons, Volatile Organic Compounds, and Tobacco-Specific Nitrosamines and Incidence of Esophageal Cancer', Journal of the National Cancer Institute, 116(3), pp. 379-388.

Vancouver

Etemadi A, Poustchi H, Chang CM, Calafat AM, Blount BC, Bhandari D, et al.. Exposure to Polycyclic Aromatic Hydrocarbons, Volatile Organic Compounds, and Tobacco-Specific Nitrosamines and Incidence of Esophageal Cancer. Journal of the National Cancer Institute. 2024;116(3):379-388.

BibTex

@article{ author = {Etemadi A and Poustchi H and Chang CM and Calafat AM and Blount BC and Bhandari D and Wang L and Roshandel G and Alexandridis A and Botelho JC and Xia B and Wang Y and Sosnoff CS and Feng J and Nalini M and Khoshnia M and Pourshams A and Sotoudeh M and Gail MH and Dawsey SM and Kamangar F and Boffetta P and Brennan P and Abnet CC and Malekzadeh R and Freedman ND}, title = {Exposure to Polycyclic Aromatic Hydrocarbons, Volatile Organic Compounds, and Tobacco-Specific Nitrosamines and Incidence of Esophageal Cancer}, journal = {Journal of the National Cancer Institute}, volume = {116}, number = {3}, pages = {379-388}, year = {2024} }

RIS

TY - JOUR
AU - Etemadi A
AU - Poustchi H
AU - Chang CM
AU - Calafat AM
AU - Blount BC
AU - Bhandari D
AU - Wang L
AU - Roshandel G
AU - Alexandridis A
AU - Botelho JC
AU - Xia B
AU - Wang Y
AU - Sosnoff CS
AU - Feng J
AU - Nalini M
AU - Khoshnia M
AU - Pourshams A
AU - Sotoudeh M
AU - Gail MH
AU - Dawsey SM
AU - Kamangar F
AU - Boffetta P
AU - Brennan P
AU - Abnet CC
AU - Malekzadeh R
AU - Freedman ND
TI - Exposure to Polycyclic Aromatic Hydrocarbons, Volatile Organic Compounds, and Tobacco-Specific Nitrosamines and Incidence of Esophageal Cancer
JO - Journal of the National Cancer Institute
VL - 116
IS - 3
SP - 379
EP - 388
PY - 2024
ER -

Science Communicator Platform

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Abstract