Spirulina Platensis As a Natural Antileishmanial Candidate: Effective Inhibition of Lrv2+ and Lrv2− Leishmania Major Isolates in Vitro

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Spirulina Platensis As a Natural Antileishmanial Candidate: Effective Inhibition of Lrv2+ and Lrv2− Leishmania Major Isolates in Vitro Publisher

Allahmoradi M ; Hajjaran H ; Mirabedini Z ; Mirjalali H ; Mohebali M ; Mohammadighalehbin B

Source: Iranian Journal of Parasitology Published:2025

Abstract

Background: Drug resistance and treatment failure in Leishmania infections are major concerns. Leishmania RNA virus 2 (LRV2) enhances host inflammation, indirectly favoring the parasite. Thus, alternative treatments are needed. Spirulina platensis has shown antimicrobial potential. Methods: The alcoholic extract of S. platensis was tested against L. major with or without LRV2. Anti-promastigote activity was evaluated directly on parasites, cytotoxicity on J774.A1 macrophages, and anti-amastigote effects using the MTT assay. Results: The extract showed significant, dose-dependent antileishmanial activity against both LRV2+ and LRV2− promastigotes (IC50 = 62.5 μg/mL). J774.A1 cells remained viable at 62.5–2000 μg/mL (P = 0.0005). Amastigote growth was inhibited at 1000 and 2000 μg/mL in both strains. Conclusion: S. platensis extract exhibits strong anti-leishmanial activity and low cytotoxicity, suggesting its potential as a natural therapeutic candidate against L. major, irrespective of LRV2 status. Further in vivo studies are warranted. Copyright © 2025 Allahmoradi et al.

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Style	Citing Format
MLA	Allahmoradi M, et al.. "Spirulina Platensis As a Natural Antileishmanial Candidate: Effective Inhibition of Lrv2+ and Lrv2− Leishmania Major Isolates in Vitro." Iranian Journal of Parasitology, vol. 20, no. 4, 2025, pp. 553-562.
APA	Allahmoradi M, Hajjaran H, Mirabedini Z, Mirjalali H, Mohebali M, Mohammadighalehbin B (2025). Spirulina Platensis As a Natural Antileishmanial Candidate: Effective Inhibition of Lrv2+ and Lrv2− Leishmania Major Isolates in Vitro. Iranian Journal of Parasitology, 20(4), 553-562.
Chicago	Allahmoradi M, Hajjaran H, Mirabedini Z, Mirjalali H, Mohebali M, Mohammadighalehbin B. "Spirulina Platensis As a Natural Antileishmanial Candidate: Effective Inhibition of Lrv2+ and Lrv2− Leishmania Major Isolates in Vitro." Iranian Journal of Parasitology 20, no. 4 (2025): 553-562.
Harvard	Allahmoradi M et al. (2025) 'Spirulina Platensis As a Natural Antileishmanial Candidate: Effective Inhibition of Lrv2+ and Lrv2− Leishmania Major Isolates in Vitro', Iranian Journal of Parasitology, 20(4), pp. 553-562.
Vancouver	Allahmoradi M, Hajjaran H, Mirabedini Z, Mirjalali H, Mohebali M, Mohammadighalehbin B. Spirulina Platensis As a Natural Antileishmanial Candidate: Effective Inhibition of Lrv2+ and Lrv2− Leishmania Major Isolates in Vitro. Iranian Journal of Parasitology. 2025;20(4):553-562.
BibTex	@article{ author = {Allahmoradi M and Hajjaran H and Mirabedini Z and Mirjalali H and Mohebali M and Mohammadighalehbin B}, title = {Spirulina Platensis As a Natural Antileishmanial Candidate: Effective Inhibition of Lrv2+ and Lrv2− Leishmania Major Isolates in Vitro}, journal = {Iranian Journal of Parasitology}, volume = {20}, number = {4}, pages = {553-562}, year = {2025} }
RIS	TY - JOUR AU - Allahmoradi M AU - Hajjaran H AU - Mirabedini Z AU - Mirjalali H AU - Mohebali M AU - Mohammadighalehbin B TI - Spirulina Platensis As a Natural Antileishmanial Candidate: Effective Inhibition of Lrv2+ and Lrv2− Leishmania Major Isolates in Vitro JO - Iranian Journal of Parasitology VL - 20 IS - 4 SP - 553 EP - 562 PY - 2025 ER -

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