Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
In Vitro and in Vivo Study of Pcl/Coll Wound Dressing Loaded With Insulin-Chitosan Nanoparticles on Cutaneous Wound Healing in Rats Model Publisher Pubmed



Ehterami A1 ; Salehi M1, 2 ; Farzamfar S3 ; Vaez A3 ; Samadian H4 ; Sahrapeyma H5 ; Mirzaii M6 ; Ghorbani S7 ; Goodarzi A3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
  2. 2. Tissue Engineering and stem cells research center, Shahroud University of Medical Sciences, Shahroud, Iran
  3. 3. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Nano Drug Delivery Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  5. 5. Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
  6. 6. Department of Microbiology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
  7. 7. Department of Anatomical Sciences, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Source: International Journal of Biological Macromolecules Published:2018


Abstract

In the current study, insulin delivering chitosan nanoparticles were coated onto the electrospun poly (ε-caprolactone) (PCL)/Collagen (COLL) to produce a potential wound care material. Electrospun matrices were fabricated from PCL/COLL (1:1 (w/w)) solution. The insulin-loaded chitosan nanoparticles were produced by ionic gelation process and then attached onto the yarns. The dressings were investigated regarding their surface wettability, microstructure, the capacity to absorb water, water vapour permeability, mechanical properties, blood compatibility, microbial penetration, and cellular behavior. Full-thickness excisional wound model was used to assess the in vivo healing capacity of the dressings. Our data showed that after 14 days the wounds covered with PCL/COLL/Cs-Ins wound dressing could reach to nearly full wound closure compared with the sterile gauze which exhibited nearly 45% of wound size reduction. Our results suggest that fabricated scaffolds can be potentially applied in clinical practice for wound treatment. © 2018 Elsevier B.V.
Related Docs
View other Related Docs
1. Erythropoietin/Aloe Vera-Releasing Wet-Electrospun Polyvinyl Alcohol/Chitosan Sponge-Like Wound Dressing: In Vitro and in Vivo Studies, Journal of Bioactive and Compatible Polymers (2018)
2. Kaolin-Loaded Chitosan/Polyvinyl Alcohol Electrospun Scaffold As a Wound Dressing Material: In Vitro and in Vivo Studies, Journal of Wound Care (2020)
3. Taurine-Loaded Poly (Ε-Caprolactone)/Gelatin Electrospun Mat As a Potential Wound Dressing Material: In Vitro and in Vivo Evaluation, Journal of Bioactive and Compatible Polymers (2018)
4. Cerium Oxide Nanoparticle-Containing Poly (Ε-Caprolactone)/Gelatin Electrospun Film As a Potential Wound Dressing Material: In Vitro and in Vivo Evaluation, Materials Science and Engineering C (2017)
5. The Single and Synergistic Effects of Montmorillonite and Curcumin-Loaded Chitosan Microparticles Incorporated Onto Poly(Lactic Acid) Electrospun Film on Wound-Healing, Journal of Bioactive and Compatible Polymers (2018)
6. Natural Product-Based Nanomedicines for Wound Healing Purposes: Therapeutic Targets and Drug Delivery Systems, International Journal of Nanomedicine (2018)
7. Polyurethane/Gelatin Nanofibrils Neural Guidance Conduit Containing Platelet-Rich Plasma and Melatonin for Transplantation of Schwann Cells, Cellular and Molecular Neurobiology (2018)
8. Cellulose Acetate Electrospun Nanofibers for Drug Delivery Systems: Applications and Recent Advances, Carbohydrate Polymers (2018)
Experts (# of related papers)
View all Related Experts
Reza Faridi Majidi (4)
Seyed Mahdi Rezayat Sorkhabadi (3)
Other Related Docs
9. Enhanced Sciatic Nerve Regeneration With Fibrin Scaffold Containing Human Endometrial Stem Cells and Insulin Encapsulated Chitosan Particles: An in Vivo Study, Injury (2023)
10. Evaluation of Effective Needleless Electrospinning Parameters Controlling Polyacrylonitrile Nanofibers Diameter Via Modeling Artificial Neural Networks, Journal of the Textile Institute (2019)
11. Chitosan/Alginate Hydrogels Containing Alpha-Tocopherol for Wound Healing in Rat Model, Journal of Drug Delivery Science and Technology (2019)
12. Fabrication of Poly(L-Lactic Acid)/Chitosan Scaffolds by Solid-Liquid Phase Separation Method for Nerve Tissue Engineering: An in Vitro Study on Human Neuroblasts, Journal of Craniofacial Surgery (2019)
13. Various Parameters in the Preparation of Chitosan/Polyethylene Oxide Electrospun Nanofibers Containing Aloe Vera Extract for Medical Applications, Nanomedicine Journal (2020)
14. Unrestricted Somatic Stem Cells Loaded in Nanofibrous Conduit As Potential Candidate for Sciatic Nerve Regeneration, Journal of Molecular Neuroscience (2019)
15. Sciatic Nerve Regeneration by Transplantation of Schwann Cells Via Erythropoietin Controlled-Releasing Polylactic Acid/Multiwalled Carbon Nanotubes/Gelatin Nanofibrils Neural Guidance Conduit, Journal of Biomedical Materials Research - Part B Applied Biomaterials (2018)
16. Neural Tissue Regeneration by a Gabapentin-Loaded Cellulose Acetate/Gelatin Wet-Electrospun Scaffold, Cellulose (2018)
17. Sciatic Nerve Regeneration With Collagen Type I Hydrogel Containing Chitosan Nanoparticle Loaded by Insulin, International Journal of Polymeric Materials and Polymeric Biomaterials (2019)
18. Evaluation of the Effects of Hyaluronic Acid on Poly (3-Hydroxybutyrate)/Chitosan/Carbon Nanotubes Electrospun Scaffold: Structure and Mechanical Properties, Polymer-Plastics Technology and Materials (2019)
19. Cellulose Acetate/Plerixafor Wound Dressings for Transplantation of Menstrual Blood Stem Cells: Potential Treatment Modality for Diabetic Wounds, Journal of Drug Delivery Science and Technology (2022)
20. In Vitro and in Vivo Evaluation of Electrospun Cellulose Acetate/Gelatin/Hydroxyapatite Nanocomposite Mats for Wound Dressing Applications, Artificial Cells# Nanomedicine and Biotechnology (2018)
21. Biological Evaluation of the Effects of Hyaluronic Acid on Poly (3-Hydroxybutyrate) Based Electrospun Nanocomposite Scaffolds for Cartilage Tissue Engineering Application, Materials Technology (2020)
22. Sciatic Nerve Regeneration by Using Collagen Type I Hydrogel Containing Naringin, Journal of Materials Science: Materials in Medicine (2019)
23. Polyurethane/Carboxymethylcellulose Nanofibers Containing Malva Sylvestris Extract for Healing Diabetic Wounds: Preparation, Characterization, in Vitro and in Vivo Studies, Materials Science and Engineering C (2020)
24. Bone Regeneration in Rat Using a Gelatin/Bioactive Glass Nanocomposite Scaffold Along With Endothelial Cells (Huvecs), International Journal of Applied Ceramic Technology (2018)
25. Fabrication and Characterization of Nanofibrous Poly (L-Lactic Acid)/Chitosan-Based Scaffold by Liquid–Liquid Phase Separation Technique for Nerve Tissue Engineering, Molecular Biotechnology (2021)
26. Polycaprolactone/Gelatin Nanofibrous Scaffolds for Tissue Engineering, Biointerface Research in Applied Chemistry (2021)
27. Evaluation of the Effective Electrospinning Parameters Controlling Kefiran Nanofibers Diameter Using Modelling Artificial Neural Networks, Nanomedicine Research Journal (2017)
28. Electrospun Cellulose Acetate/Gelatin Nanofibrous Wound Dressing Containing Berberine for Diabetic Foot Ulcer Healing: In Vitro and in Vivo Studies, Scientific Reports (2020)
29. A Tailored Polylactic Acid/Polycaprolactone Biodegradable and Bioactive 3D Porous Scaffold Containing Gelatin Nanofibers and Taurine for Bone Regeneration, Scientific Reports (2020)
30. Antibacterial and Antioxidant Assessment of Cellulose Acetate/Polycaprolactone Nanofibrous Mats Impregnated With Propolis, International Journal of Biological Macromolecules (2019)
31. Simple and Robust Fabrication and Characterization of Conductive Carbonized Nanofibers Loaded With Gold Nanoparticles for Bone Tissue Engineering Applications, Materials Science and Engineering C (2020)
32. A Novel Polycaprolactone/Carbon Nanofiber Composite As a Conductive Neural Guidance Channel: An in Vitro and in Vivo Study, Progress in Biomaterials (2019)
33. Preparation and Characterization of Pcl Polymeric Scaffolds Coated With Chitosan/ Bioactive Glass/Gelatin Nanoparticles Using the Tips Methodology for Bone Tissue Engineering, Nanomedicine Journal (2019)
34. How Biomimetic Nanofibers Advance the Realm of Cutaneous Wound Management: The State-Of-The-Art and Future Prospects, Progress in Materials Science (2024)
35. Encapsulation of Curcumin Loaded Chitosan Nanoparticle Within Poly (Ε-Caprolactone) and Gelatin Fiber Mat for Wound Healing and Layered Dermal Reconstitution, International Journal of Biological Macromolecules (2020)