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Factors Associated With Prolonged Qtc Interval in Iranian Population: Mashad Cohort Study Publisher



Sahranavard T1 ; Soflaei SS1, 3 ; Alimi R2 ; Pourali G3 ; Nasrabadi M4 ; Yadollahi A5 ; Sharifi S5 ; Alimi H6 ; Shahri B5 ; Ghalibaf AM7 ; Metanat S8 ; Ferns GA9 ; Moohebati M10, 11 ; Ghayourmobarhan M1, 3
Authors
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Authors Affiliations
  1. 1. International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
  2. 2. Department of Epidemiology and Biostatistics, School of Health, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
  3. 3. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  5. 5. Department of Cardiovascular Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  6. 6. Vascular and Endovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran
  8. 8. Center for Orthopedic Trans-Disciplinary Applied Research, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Division of Medical Education, Brighton & Sussex Medical School, Falmer, Brighton, Sussex, United Kingdom
  10. 10. Heart and Vascular Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  11. 11. Department of Cardiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Journal of Electrocardiology Published:2024


Abstract

Aim: QTc interval prolongation is a growing global issue which can cause torsades de pointes, a potentially fatal arrhythmia. We aimed to identify risk factors for prolonged QT interval in men and women. Methods: The Mashhad stroke and heart atherosclerotic disorder (MASHAD) cohort study collected electrocardiogram interval data. QT was corrected for heart rate using the Bazett's formula. Ordinal logistic regression with crude (univariable) and adjusted (multivariate) association analyses in the form of odds ratio and corresponding 95% confidence interval (CI) were used to identify the factors associated with QTc prolongation. Results: A total of 8878 individuals including 5318 females and 3560 males, aged 35 to 65 years, were included in this cross-sectional study. Participants with QTc prolongation were more likely to be older and have hypercholesterolemia, hypertension (HTN), and Type 2 diabetes mellitus (T2DM), but to have lower levels of physical activity (P < 0.05). Age (OR = 1.68, 95%CI = 1.18–2.39), hypercholesterolemia (OR = 1.77, 95%CI = 1.24–2.51), HTN (OR = 1.36, 95%CI = 1.06–1.73), T2DM (OR = 1.59, 95%CI = 1.19–2.13), severe anxiety (OR = 1.80, 95%CI = 1.05–3.11) and mild depression (OR = 1.38, 95%CI = 1.01–1.88) were independent risk factors for prolonged QTc interval in men. For women, only HTN (OR = 1.29, 95%CI = 1.02–1.63) and T2DM (OR = 1.50, 95%CI = 1.14–1.97) were independent risk factors. Conclusions: Older age, Hypercholesterolemia, HTN, T2DM, severe anxiety and mild depression in men, and HTN and T2DM in women were associated with high risk of prolonged QTc interval. Healthcare practitioners should be aware of the risk factors of QTc interval prolongation and should exercise caution in the management of certain patients. © 2024
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