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The Role of Angiotensin-Converting Enzyme 2 in Covid-19 Induced Lung Injury Publisher Pubmed



Torabi S1 ; Bahreini F2, 3 ; Rezaei N3, 4, 5, 6
Authors
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Authors Affiliations
  1. 1. Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
  3. 3. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Networ(USERN), Tehran, Iran
  4. 4. Research Center for Immunodeficiencies (RCID), Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Research Center for Immunodeficiencies, Children’s Medical Center Hospital, Dr. Qarib St, Keshavarz Blvd, Tehran, 14194, Iran

Source: Acta Biomedica Published:2020


Abstract

The novel coronavirus disease (COVID-19) has affected people around the world both physically and psychologically. As result, developing a coronavirus-specific vaccine and/or therapeutics is now a top priority for public health agencies. Since our findings of COVID-19 are relatively new, the current knowledge about the molecular mechanism involved in pathogenicity and virulence of the novel coronavirus is not advanced. Understanding angiotensin-converting enzyme 2 (ACE2), the receptor for the coronavirus, is significantly important. To better illustrate the role of ACE2 in the severity of COVID-19 and the impact of currently used drugs on this receptor, this paper briefly reviews newly published articles in this regard. (www.actabiomedica.it). © Mattioli 1885.
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