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Microbial Cellulosic Pad Encompassing Alpha-Arbutin in Tragacanth Gum As the Controlled Delivery System Publisher Pubmed



Fahim NH1 ; Montazer M1 ; Hemmatinejad N1 ; Toliyat T2 ; Rad MM3
Authors
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Authors Affiliations
  1. 1. Department of Textile Engineering, Functional Fibrous Structures & Environmental Enhancement (FFSEE), Amirkabir University of Technology, Tehran, Iran
  2. 2. School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: International Journal of Biological Macromolecules Published:2023


Abstract

This research focuses on preparing a natural-based drug delivery system for α-arbutin (AR) as a skin lightening. Bacterial cellulose nanofibers (BC) pad was used for controlled-AR release through two approaches. First was the dip-drying method (P-BC), in which AR cross-linked to BC pads using citric acid (CA). The second was simultaneously entrapping of AR in Tragacanth gum (AR-TG) and stabilized on BC (BC-T) through the ultrasonic-assisted microemulsion method. UV–Vis spectra revealed better control of AR release in BC-T in the first hour. High cell viability (above 70 %) of the pads containing 1–3 % AR was reported using MTT assay. The in-vitro permeation study indicated the proper AR penetration in the treated pads. The Fickian diffusion model was determined as a fitted model for all pads in the drug release kinetics. FTIR, XRD, and TGA analyses further characterized the pads. FESEM images verified AR-TG and BC structures with average diameters of 410.7 ± 25.4 and 34.5 ± 7.51 nm, respectively. The hydrophilicity and mechanical properties of the pads were also investigated. Finally, the high biocompatibility, initial controlled release, and proper permeation suggested BC-T as a more promising delivery platform for AR. © 2023 Elsevier B.V.
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