In Vitro Chromosomal Radiosensitivity in Patients With Common Variable Immunodeficiency

In Vitro Chromosomal Radiosensitivity in Patients With Common Variable Immunodeficiency Publisher

Mahmoodi M^{1, 2} ; Abolhassani H² ; Mozdarani H³ ; Rezaei N² ; Azizi G⁴ ; Yazdani R² ; Farzanfar F¹ ; Rafiemanesh H⁵ ; Mohagheghi MA¹ ; Divsalar K⁶ ; Kalmarzi RN² ; Ramyar A² ; Aghamohammadi A²

Show Affiliations

1. Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
2. Research Center for Immunodeficiencies, Children's Medical Center Hospital, Tehran University of Medical Sciences, 62 Qarib St., Tehran, 14194, Iran
3. Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
4. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
5. School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6. Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

Source: Central European Journal of Immunology Published:2018

Abstract

Common variable immunodeficiency (CVID) is one of the predominant antibody deficiency disorders, some evidence of which indicates that chromosome instability is present in these patients. An increased risk of cancer in patients with CVID has been documented. This study was undertaken to highlight radiation sensitivity in CVID patients and to clarify the genetic basis of this defect in these cases. Stimulated lymphocytes of the studied subjects were exposed to low-dose gamma-rays in the G2 phase or the G0 phase of the cell cycle and chromosomal aberrations were scored. Lymphocytes of healthy individuals, ataxia telangiectasia (AT) cases and a group of acute lymphoblastic leukemia (ALL) patients were investigated in the same way as controls. By two methods of analysis (one-way ANOVA and unpaired t-test), the CVID cases were significantly more radiosensitive than healthy controls based on the results of the G2 and the G0 assays. First-degree relatives of CVID patients were radiosensitive by the micronucleus assay which showed a significant difference as compared with normal controls (p = 0.001). In conclusion, this study may support that chromosomal radiosensitivity in CVID patients is a marker of genetic predisposition to the disease. The results might be a clue to describe the increased risk of cancer in CVID patients. © 2018 Termedia Publishing House Ltd. All rights reserved.

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Style	Citing Format
MLA	Mahmoodi M, et al.. "In Vitro Chromosomal Radiosensitivity in Patients With Common Variable Immunodeficiency." Central European Journal of Immunology, vol. 43, no. 2, 2018, pp. 155-161.
APA	Mahmoodi M, Abolhassani H, Mozdarani H, Rezaei N, Azizi G, Yazdani R, Farzanfar F, Rafiemanesh H, Mohagheghi MA, Divsalar K, Kalmarzi RN, Ramyar A, Aghamohammadi A (2018). In Vitro Chromosomal Radiosensitivity in Patients With Common Variable Immunodeficiency. Central European Journal of Immunology, 43(2), 155-161.
Chicago	Mahmoodi M, Abolhassani H, Mozdarani H, Rezaei N, Azizi G, Yazdani R, Farzanfar F, et al.. "In Vitro Chromosomal Radiosensitivity in Patients With Common Variable Immunodeficiency." Central European Journal of Immunology 43, no. 2 (2018): 155-161.
Harvard	Mahmoodi M et al. (2018) 'In Vitro Chromosomal Radiosensitivity in Patients With Common Variable Immunodeficiency', Central European Journal of Immunology, 43(2), pp. 155-161.
Vancouver	Mahmoodi M, Abolhassani H, Mozdarani H, Rezaei N, Azizi G, Yazdani R, et al.. In Vitro Chromosomal Radiosensitivity in Patients With Common Variable Immunodeficiency. Central European Journal of Immunology. 2018;43(2):155-161.
BibTex	@article{ author = {Mahmoodi M and Abolhassani H and Mozdarani H and Rezaei N and Azizi G and Yazdani R and Farzanfar F and Rafiemanesh H and Mohagheghi MA and Divsalar K and Kalmarzi RN and Ramyar A and Aghamohammadi A}, title = {In Vitro Chromosomal Radiosensitivity in Patients With Common Variable Immunodeficiency}, journal = {Central European Journal of Immunology}, volume = {43}, number = {2}, pages = {155-161}, year = {2018} }
RIS	TY - JOUR AU - Mahmoodi M AU - Abolhassani H AU - Mozdarani H AU - Rezaei N AU - Azizi G AU - Yazdani R AU - Farzanfar F AU - Rafiemanesh H AU - Mohagheghi MA AU - Divsalar K AU - Kalmarzi RN AU - Ramyar A AU - Aghamohammadi A TI - In Vitro Chromosomal Radiosensitivity in Patients With Common Variable Immunodeficiency JO - Central European Journal of Immunology VL - 43 IS - 2 SP - 155 EP - 161 PY - 2018 ER -

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