Physicochemical Characteristics of Liposomes Are Decisive for Their Antirestenosis Efficacy Following Local Delivery

Physicochemical Characteristics of Liposomes Are Decisive for Their Antirestenosis Efficacy Following Local Delivery Publisher Pubmed

Haeri A¹ ; Sadeghian S² ; Rabbani S² ; Shirani S² ; Anvari MS² ; Dadashzadeh S^{1, 3}

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1. Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
3. Pharmaceutical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Nanomedicine Published:2017

Abstract

Aim: To develop an ameliorated sirolimus (SIR) liposome for intramural delivery, the effects of various carrier physicochemical parameters on the antirestenosis efficacy were evaluated. Materials & methods: Different liposomes were prepared, characterized and administered to balloon injured rats (12 animal groups). Their efficacies were investigated using morphometric, immunohistochemical and in vivo computed tomography imaging analyses. Results: The antirestenosis efficacy of SIR liposomes decreased in the following order: cationic 100 nm vesicles ≥ cationic 60 nm vesicles > neutral 100 nm vesicles ≥ stealth 100 nm vesicles > anionic 100 nm vesicles. The 100 μg SIR loaded in cationic liposomes showed almost no artery stenosis. Conclusion: Appropriate modulation of physicochemical characteristics makes it possible to optimize the liposomes for local delivery. © 2017 Future Medicine Ltd.

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Shahram Rabbani (6)

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Style	Citing Format
MLA	Haeri A, et al.. "Physicochemical Characteristics of Liposomes Are Decisive for Their Antirestenosis Efficacy Following Local Delivery." Nanomedicine, vol. 12, no. 2, 2017, pp. 131-145.
APA	Haeri A, Sadeghian S, Rabbani S, Shirani S, Anvari MS, Dadashzadeh S (2017). Physicochemical Characteristics of Liposomes Are Decisive for Their Antirestenosis Efficacy Following Local Delivery. Nanomedicine, 12(2), 131-145.
Chicago	Haeri A, Sadeghian S, Rabbani S, Shirani S, Anvari MS, Dadashzadeh S. "Physicochemical Characteristics of Liposomes Are Decisive for Their Antirestenosis Efficacy Following Local Delivery." Nanomedicine 12, no. 2 (2017): 131-145.
Harvard	Haeri A et al. (2017) 'Physicochemical Characteristics of Liposomes Are Decisive for Their Antirestenosis Efficacy Following Local Delivery', Nanomedicine, 12(2), pp. 131-145.
Vancouver	Haeri A, Sadeghian S, Rabbani S, Shirani S, Anvari MS, Dadashzadeh S. Physicochemical Characteristics of Liposomes Are Decisive for Their Antirestenosis Efficacy Following Local Delivery. Nanomedicine. 2017;12(2):131-145.
BibTex	@article{ author = {Haeri A and Sadeghian S and Rabbani S and Shirani S and Anvari MS and Dadashzadeh S}, title = {Physicochemical Characteristics of Liposomes Are Decisive for Their Antirestenosis Efficacy Following Local Delivery}, journal = {Nanomedicine}, volume = {12}, number = {2}, pages = {131-145}, year = {2017} }
RIS	TY - JOUR AU - Haeri A AU - Sadeghian S AU - Rabbani S AU - Shirani S AU - Anvari MS AU - Dadashzadeh S TI - Physicochemical Characteristics of Liposomes Are Decisive for Their Antirestenosis Efficacy Following Local Delivery JO - Nanomedicine VL - 12 IS - 2 SP - 131 EP - 145 PY - 2017 ER -

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