Alginate Nanoparticles Containing Lavandula Angustifolia Essential Oil As a Potential Potent, Biocompatible and Low-Cost Antitumor Agent

Alginate Nanoparticles Containing Lavandula Angustifolia Essential Oil As a Potential Potent, Biocompatible and Low-Cost Antitumor Agent Publisher

Valizadeh A¹ ; Hosseinzadeh M² ; Heiran R³ ; Hatami S⁴ ; Hosseinipour A⁵ ; Osanloo M⁶

Show Affiliations

1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran
3. Estahban Higher Education Center-Shiraz University, Estahban, Iran
4. Department of Biochemistry, School of Medicine, Fasa University of Medical Science, Fasa, Iran
5. Noncommunicable Disease Research Center, Fasa University of Medical Sciences, Fasa, Iran
6. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran

Source: Polymer Bulletin Published:2024

Abstract

This study aimed to investigate the anticancer activity of Lavandula angustifolia essential oil (LAEO) and alginate nanoparticles containing L. angustifolia essential oil (Alg/LAEO NPs). GC–MS was applied for the characterization of LAEO components. Alg/LAEO NPs were prepared by low-energy methods, and their size was analyzed by DLS. In addition, cytotoxicity of LAEO and Alg/LAEO NPs on A-375 (melanoma) and MCF-7 (breast) cell lines was evaluated by MTT assay, and gene expression was evaluated by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) method. Linalool acetate (31.325%), linalool (24.407%), camphor (7.420%), 1,8-cineole (6.524%), and borneol (4.101%) were five major constituents of LAEO. The average particle size of Alg/LAEO NPs was 185 ± 7 nm. Alg/LAEO NPs with IC50 values of 405 and 120 against A-375 and MCF-7 cells were significantly more potent than LAEO (2299 and 522 µg/mL). Besides, LAEO and Alg/LAEO NPs affect apoptosis regulator genes; apoptosis criteria were proven as molar ratios of Bax and BLC-2 were more than 1. Therefore, Alg/LAEO NPs, as a potent green anticancer agent, could be considered for in vivo studies. © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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Style	Citing Format
MLA	Valizadeh A, et al.. "Alginate Nanoparticles Containing Lavandula Angustifolia Essential Oil As a Potential Potent, Biocompatible and Low-Cost Antitumor Agent." Polymer Bulletin, vol. 81, no. 2, 2024, pp. 1861-1874.
APA	Valizadeh A, Hosseinzadeh M, Heiran R, Hatami S, Hosseinipour A, Osanloo M (2024). Alginate Nanoparticles Containing Lavandula Angustifolia Essential Oil As a Potential Potent, Biocompatible and Low-Cost Antitumor Agent. Polymer Bulletin, 81(2), 1861-1874.
Chicago	Valizadeh A, Hosseinzadeh M, Heiran R, Hatami S, Hosseinipour A, Osanloo M. "Alginate Nanoparticles Containing Lavandula Angustifolia Essential Oil As a Potential Potent, Biocompatible and Low-Cost Antitumor Agent." Polymer Bulletin 81, no. 2 (2024): 1861-1874.
Harvard	Valizadeh A et al. (2024) 'Alginate Nanoparticles Containing Lavandula Angustifolia Essential Oil As a Potential Potent, Biocompatible and Low-Cost Antitumor Agent', Polymer Bulletin, 81(2), pp. 1861-1874.
Vancouver	Valizadeh A, Hosseinzadeh M, Heiran R, Hatami S, Hosseinipour A, Osanloo M. Alginate Nanoparticles Containing Lavandula Angustifolia Essential Oil As a Potential Potent, Biocompatible and Low-Cost Antitumor Agent. Polymer Bulletin. 2024;81(2):1861-1874.
BibTex	@article{ author = {Valizadeh A and Hosseinzadeh M and Heiran R and Hatami S and Hosseinipour A and Osanloo M}, title = {Alginate Nanoparticles Containing Lavandula Angustifolia Essential Oil As a Potential Potent, Biocompatible and Low-Cost Antitumor Agent}, journal = {Polymer Bulletin}, volume = {81}, number = {2}, pages = {1861-1874}, year = {2024} }
RIS	TY - JOUR AU - Valizadeh A AU - Hosseinzadeh M AU - Heiran R AU - Hatami S AU - Hosseinipour A AU - Osanloo M TI - Alginate Nanoparticles Containing Lavandula Angustifolia Essential Oil As a Potential Potent, Biocompatible and Low-Cost Antitumor Agent JO - Polymer Bulletin VL - 81 IS - 2 SP - 1861 EP - 1874 PY - 2024 ER -

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