The Importance of Accessory Protein Variants in the Pathogenicity of Sars-Cov-2

The Importance of Accessory Protein Variants in the Pathogenicity of Sars-Cov-2 Publisher Pubmed

Hassan SS¹ ; Choudhury PP² ; Aljabali AAA⁴ ; Uhal BD⁵ ; Lundstrom K⁶ ; Rezaei N^{7, 32} ; Pizzol D⁸ ; Adadi P⁹ ; Lal A¹⁰ ; Soares A¹¹ ; Mohamed Abd Elaziz T^{11, 12} ; Brufsky AM¹³ ; Azad GK¹⁴ ; Sherchan SP¹⁵ Show All Authors

Hassan SS¹
Choudhury PP²
Aljabali AAA⁴
Uhal BD⁵
Lundstrom K⁶
Rezaei N^{7, 32}
Pizzol D⁸
Adadi P⁹
Lal A¹⁰
Soares A¹¹
Mohamed Abd Elaziz T^{11, 12}
Brufsky AM¹³
Azad GK¹⁴
Sherchan SP¹⁵
Baetasdacruz W¹⁶
Takayama K¹⁷
Serranoaroca A¹⁸
Chauhan G¹⁹
Palu G²⁰
Mishra YK²¹
Barh D^{22, 23}
Santana Silva RJ²⁴
Andrade BS²⁵
Azevedo V²³
Goesneto A²⁶
Bazan NG²⁷
Redwan EM²⁸
Tambuwala M²⁹
Uversky VN^{30, 31}

Show Affiliations

1. Department of Mathematics, Pingla Thana Mahavidyalaya, Maligram, 721140, India
2. Applied Statistics Unit, Indian Statistical Institute, Kolkata, 700108, West Bengal, India
3. Department of Chemistry, College of Art and Sciences, University of South Florida, Tampa, 33620, FL, United States
4. Department of Pharmaceutics and Pharmaceutical Technology, Yarmouk University-Faculty of Pharmacy, Irbid, 566, Jordan
5. Department of Physiology, Michigan State University, East Lansing, 48824, MI, United States
6. PanTherapeutics, Rte de Lavaux 49, Lutry, CH1095, Switzerland
7. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
8. Italian Agency for Development Cooperation - Khartoum, Sudan Street 33, Al Amarat, Sudan
9. Department of Food Science, University of Otago, Dunedin, 9054, New Zealand
10. Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, United States
11. Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, 78229-3900, TX, United States
12. Zoology Department, Faculty of Science, Minia University, El-Minia, 61519, Egypt
13. University of Pittsburgh School of Medicine, Department of Medicine, Division of Hematology/Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, United States
14. Department of Zoology, Patna University, Patna, 800005, Bihar, India
15. Department of Environmental Health Sciences, Tulane University, New Orleans, 70112, LA, United States
16. Translational Laboratory in Molecular Physiology, Centre for Experimental Surgery, College of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil
17. Center for iPS Cell Research and Application, Kyoto University, Japan
18. Biomaterial and Bioengineering Lab, Translational Research Centre San Alberto Magno, Catholic University of Valencia San Vicente M'artir, c/Guillem de Castro 94, Valencia, 46001, Spain
19. School of Engineering and Sciences, Tecnologico de Monterrey, Av. Eugenio Garza Sada 2501 Sur, Monterrey, 64849, Nuevo Leon, Mexico
20. Department of Molecular Medicine, University of Padova, Via Gabelli 63, Padova, 35121, Italy
21. University of Southern Denmark, Mads Clausen Institute, NanoSYD, Alsion 2, Sonderborg, 6400, Denmark
22. Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, WB, India
23. Departamento de Genetica, Ecologia e Evolucao, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
24. Departamento de Ciencias Biologicas (DCB), Programa de Pos-Graduacao em Genetica e Biologia Molecular (PPGGBM), Universidade Estadual de Santa Cruz (UESC), Rodovia Ilheus-Itabuna, km 16, Ilheus, 45662-900, BA, Brazil
25. Laboratorio de Bioinformatica e Quimica Computacional, Departamento de Ciencias Biologicas, Universidade Estadual do Sudoeste da Bahia (UESB), Jequie, 45206-190, Brazil
26. Laboratorio de Biologia Molecular e Computacional de Fungos, Departamento de Microbiologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil
27. Neuroscience Center of Excellence, School of Medicine, LSU Health New Orleans, New Orleans, 70112, LA, United States
28. King Abdulaz University, Faculty of Science, Department of Biological Science, Saudi Arabia
29. School of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine, BT52 1SA, Northern Ireland, Ireland
30. Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, 33612, FL, United States
31. Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Institutskiy pereulok, 9, Dolgoprudny, 141700, Moscow region, Russian Federation
32. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Stockholm, Sweden

Source: Archives of Biochemistry and Biophysics Published:2022

Abstract

The coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS- CoV-2) with an estimated fatality rate of less than 1%. The SARS-CoV-2 accessory proteins ORF3a, ORF6, ORF7a, ORF7b, ORF8, and ORF10 possess putative functions to manipulate host immune mechanisms. These involve interferons, which appear as a consensus function, immune signaling receptor NLRP3 (NLR family pyrin domain-containing 3) inflammasome, and inflammatory cytokines such as interleukin 1β (IL-1β) and are critical in COVID-19 pathology. Outspread variations of each of the six accessory proteins were observed across six continents of all complete SARS-CoV-2 proteomes based on the data reported before November 2020. A decreasing order of percentage of unique variations in the accessory proteins was determined as ORF3a > ORF8 > ORF7a > ORF6 > ORF10 > ORF7b across all continents. The highest and lowest unique variations of ORF3a were observed in South America and Oceania, respectively. These findings suggest that the wide variations in accessory proteins seem to affect the pathogenicity of SARS-CoV-2. © 2022 Elsevier Inc.

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Style	Citing Format
MLA	Hassan SS, et al.. "The Importance of Accessory Protein Variants in the Pathogenicity of Sars-Cov-2." Archives of Biochemistry and Biophysics, vol. 717, no. , 2022, pp. -.
APA	Hassan SS, Choudhury PP, Aljabali AAA, Uhal BD, Lundstrom K, Rezaei N, Pizzol D, Adadi P, Lal A, Soares A, Mohamed Abd Elaziz T, Brufsky AM, Azad GK, Sherchan SP, Baetasdacruz W, Takayama K, Serranoaroca A, Chauhan G, Palu G, ... Uversky VN (2022). The Importance of Accessory Protein Variants in the Pathogenicity of Sars-Cov-2. Archives of Biochemistry and Biophysics, 717(), -.
Chicago	Hassan SS, Choudhury PP, Aljabali AAA, Uhal BD, Lundstrom K, Rezaei N, Pizzol D, et al.. "The Importance of Accessory Protein Variants in the Pathogenicity of Sars-Cov-2." Archives of Biochemistry and Biophysics 717, no. (2022): -.
Harvard	Hassan SS et al. (2022) 'The Importance of Accessory Protein Variants in the Pathogenicity of Sars-Cov-2', Archives of Biochemistry and Biophysics, 717(), pp. -.
Vancouver	Hassan SS, Choudhury PP, Aljabali AAA, Uhal BD, Lundstrom K, Rezaei N, et al.. The Importance of Accessory Protein Variants in the Pathogenicity of Sars-Cov-2. Archives of Biochemistry and Biophysics. 2022;717():-.
BibTex	@article{ author = {Hassan SS and Choudhury PP and Aljabali AAA and Uhal BD and Lundstrom K and Rezaei N and Pizzol D and Adadi P and Lal A and Soares A and Mohamed Abd Elaziz T and Brufsky AM and Azad GK and Sherchan SP and Baetasdacruz W and Takayama K and Serranoaroca A and Chauhan G and Palu G and Mishra YK and Barh D and Santana Silva RJ and Andrade BS and Azevedo V and Goesneto A and Bazan NG and Redwan EM and Tambuwala M and Uversky VN}, title = {The Importance of Accessory Protein Variants in the Pathogenicity of Sars-Cov-2}, journal = {Archives of Biochemistry and Biophysics}, volume = {717}, number = {}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Hassan SS AU - Choudhury PP AU - Aljabali AAA AU - Uhal BD AU - Lundstrom K AU - Rezaei N AU - Pizzol D AU - Adadi P AU - Lal A AU - Soares A AU - Mohamed Abd Elaziz T AU - Brufsky AM AU - Azad GK AU - Sherchan SP AU - Baetasdacruz W AU - Takayama K AU - Serranoaroca A AU - Chauhan G AU - Palu G AU - Mishra YK AU - Barh D AU - Santana Silva RJ AU - Andrade BS AU - Azevedo V AU - Goesneto A AU - Bazan NG AU - Redwan EM AU - Tambuwala M AU - Uversky VN TI - The Importance of Accessory Protein Variants in the Pathogenicity of Sars-Cov-2 JO - Archives of Biochemistry and Biophysics VL - 717 IS - SP - EP - PY - 2022 ER -

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