A Unique View of Sars-Cov-2 Through the Lens of Orf8 Protein

A Unique View of Sars-Cov-2 Through the Lens of Orf8 Protein Publisher Pubmed

Hassan SS¹ ; Aljabali AAA² ; Panda PK³ ; Ghosh S⁴ ; Attrish D⁵ ; Choudhury PP⁶ ; Seyran M⁷ ; Pizzol D⁸ ; Adadi P⁹ ; Abd Elaziz TM^{10, 11} ; Soares A¹¹ ; Kandimalla R¹² ; Lundstrom K¹³ ; Lal A¹⁴ Show All Authors

Hassan SS¹
Aljabali AAA²
Panda PK³
Ghosh S⁴
Attrish D⁵
Choudhury PP⁶
Seyran M⁷
Pizzol D⁸
Adadi P⁹
Abd Elaziz TM^{10, 11}
Soares A¹¹
Kandimalla R¹²
Lundstrom K¹³
Lal A¹⁴
Azad GK¹⁵
Uversky VN¹⁶
Sherchan SP¹⁷
Baetasdacruz W¹⁸
Uhal BD¹⁹
Rezaei N²⁰
Chauhan G²¹
Barh D²²
Redwan EM²³
Bazan NG²⁵
Serranoaroca A²⁶
Eldemerdash A²⁷
Mishra YK²⁸
Palu G²⁹
Takayama K³⁰
Brufsky AM³¹
Tambuwala MM³²

Show Affiliations

1. Department of Mathematics, Pingla Thana Mahavidyalaya, Maligram, 721140, India
2. Department of Pharmaceutics and Pharmaceutical Technology, Yarmouk University-Faculty of Pharmacy, Irbid, 566, Jordan
3. Condensed Matter Theory Group, Materials Theory Division, Department of Physics and Astronomy, Uppsala University, Box 516, Uppsala, SE-751 20, Sweden
4. Department of Biophysics, Molecular Biology and Bioinformatics, University of Calcutta, Kolkata, 700009, West Bengal, India
5. Dr. B. R. Ambedkar Centre for Biomedical Research (ACBR), University of Delhi (North Campus), Delhi, 110007, India
6. Applied Statistics Unit, Indian Statistical Institute, Kolkata, 700108, West Bengal, India
7. Doctoral Studies in Natural and Technical Sciences (SPL 44), University of Vienna, Austria
8. Italian Agency for Development Cooperation - Khartoum, Sudan Street 33, Al Amarat, Sudan
9. Department of Food Science, University of Otago, Dunedin, 9054, New Zealand
10. Zoology Department, Faculty of Science, Minia University, El-Minia, 61519, Egypt
11. Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, 78229-3900, TX, United States
12. CSIR-Indian Institute of Chemical Technology Uppal Road, Tarnaka, Telangana State, Hyderabad, 500007, India
13. PanTherapeutics, Rte de Lavaux 49, Lutry, CH1095, Switzerland
14. Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, United States
15. Department of Zoology, Patna University, Patna, 800005, Bihar, India
16. Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, 33612, FL, United States
17. Department of Environmental Health Sciences, Tulane University, New Orleans, 70112, LA, United States
18. Translational Laboratory in Molecular Physiology, Centre for Experimental Surgery, College of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil
19. Department of Physiology, Michigan State University, East Lansing, 48824, MI, United States
20. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran and Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Stockholm, Sweden
21. School of Engineering and Sciences, Tecnologico de Monterrey, Mexico Tecnologico De Monterrey, Campus Monterrey, Av. Eugenio Garza Sada 2501, Sur, Monterrey, NL, Monterrey, 64849, Nuevo Leon, Mexico
22. Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), PatnaPatna, India
23. King Abdulazizi University, Faculty of Science, Department of Biological Science, Saudi Arabia
24. Department of Chemistry, College of Art and Sciences, University of South Florida, Tampa, 33620, FL, United States
25. Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, 70112, LA, United States
26. Biomaterials and Bioengineering Lab, Translational Research Centre San Alberto Magno, Catholic University of Valencia San Vicente Martir, C/Guillem de Castro 94, Valencia, 46001, Spain
27. Natural Products and Medicinal Chemistry Department, Institute de Chimie des Substances Naturelles, Gif-sur-Yvette, France
28. University of Southern Denmark, Mads Clausen Institute, NanoSYD, Alsion 2, Sonderborg, 6400, Denmark
29. Department of Molecular Medicine, University of Padova, Italy
30. Center for IPS Cell Research and Application, Kyoto University, Kyoto, 606-8397, Japan
31. University of Pittsburgh School of Medicine, Department of Medicine, Division of Hematology/Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, United States
32. School of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine BT52 1SA, Northern Ireland, United Kingdom

Source: Computers in Biology and Medicine Published:2021

Abstract

Immune evasion is one of the unique characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) attributed to its ORF8 protein. This protein modulates the adaptive host immunity through down-regulation of MHC-1 (Major Histocompatibility Complex) molecules and innate immune responses by surpassing the host's interferon-mediated antiviral response. To understand the host's immune perspective concerning the ORF8 protein, a comprehensive study of the ORF8 protein and mutations possessed by it have been performed. Chemical and structural properties of ORF8 proteins from different hosts, such as human, bat, and pangolin, suggest that the ORF8 of SARS-CoV-2 is much closer to ORF8 of Bat RaTG13-CoV than to that of Pangolin-CoV. Eighty-seven mutations across unique variants of ORF8 in SARS-CoV-2 can be grouped into four classes based on their predicted effects (Hussain et al., 2021) [1]. Based on the geo-locations and timescale of sample collection, a possible flow of mutations was built. Furthermore, conclusive flows of amalgamation of mutations were found upon sequence similarity analyses and consideration of the amino acid conservation phylogenies. Therefore, this study seeks to highlight the uniqueness of the rapidly evolving SARS-CoV-2 through the ORF8. © 2021 The Authors

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Style	Citing Format
MLA	Hassan SS, et al.. "A Unique View of Sars-Cov-2 Through the Lens of Orf8 Protein." Computers in Biology and Medicine, vol. 133, no. , 2021, pp. -.
APA	Hassan SS, Aljabali AAA, Panda PK, Ghosh S, Attrish D, Choudhury PP, Seyran M, Pizzol D, Adadi P, Abd Elaziz TM, Soares A, Kandimalla R, Lundstrom K, Lal A, Azad GK, Uversky VN, Sherchan SP, Baetasdacruz W, Uhal BD, ... Tambuwala MM (2021). A Unique View of Sars-Cov-2 Through the Lens of Orf8 Protein. Computers in Biology and Medicine, 133(), -.
Chicago	Hassan SS, Aljabali AAA, Panda PK, Ghosh S, Attrish D, Choudhury PP, Seyran M, et al.. "A Unique View of Sars-Cov-2 Through the Lens of Orf8 Protein." Computers in Biology and Medicine 133, no. (2021): -.
Harvard	Hassan SS et al. (2021) 'A Unique View of Sars-Cov-2 Through the Lens of Orf8 Protein', Computers in Biology and Medicine, 133(), pp. -.
Vancouver	Hassan SS, Aljabali AAA, Panda PK, Ghosh S, Attrish D, Choudhury PP, et al.. A Unique View of Sars-Cov-2 Through the Lens of Orf8 Protein. Computers in Biology and Medicine. 2021;133():-.
BibTex	@article{ author = {Hassan SS and Aljabali AAA and Panda PK and Ghosh S and Attrish D and Choudhury PP and Seyran M and Pizzol D and Adadi P and Abd Elaziz TM and Soares A and Kandimalla R and Lundstrom K and Lal A and Azad GK and Uversky VN and Sherchan SP and Baetasdacruz W and Uhal BD and Rezaei N and Chauhan G and Barh D and Redwan EM and Bazan NG and Serranoaroca A and Eldemerdash A and Mishra YK and Palu G and Takayama K and Brufsky AM and Tambuwala MM}, title = {A Unique View of Sars-Cov-2 Through the Lens of Orf8 Protein}, journal = {Computers in Biology and Medicine}, volume = {133}, number = {}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Hassan SS AU - Aljabali AAA AU - Panda PK AU - Ghosh S AU - Attrish D AU - Choudhury PP AU - Seyran M AU - Pizzol D AU - Adadi P AU - Abd Elaziz TM AU - Soares A AU - Kandimalla R AU - Lundstrom K AU - Lal A AU - Azad GK AU - Uversky VN AU - Sherchan SP AU - Baetasdacruz W AU - Uhal BD AU - Rezaei N AU - Chauhan G AU - Barh D AU - Redwan EM AU - Bazan NG AU - Serranoaroca A AU - Eldemerdash A AU - Mishra YK AU - Palu G AU - Takayama K AU - Brufsky AM AU - Tambuwala MM TI - A Unique View of Sars-Cov-2 Through the Lens of Orf8 Protein JO - Computers in Biology and Medicine VL - 133 IS - SP - EP - PY - 2021 ER -

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