Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Caveolin Gene, a Possible Risk Factor for Metabolic Syndrome in Humans: A Systematic Review and Meta-Analysis Publisher



Arefian M2 ; Mazaheritehrani S2 ; Yazdi M2 ; Kelishadi R2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Journal of Preventive Medicine Published:2025


Abstract

Background: Studies show that caveolin genes are associated with metabolic disorders, so we aimed to systematically review the association between caveolin genes and metabolic syndrome in human studies. This systematic review is conducted based on the PRISMA 2020 checklist. Methods: A systematic literature search was done on electronic databases including Embase, Scopus, Medline (PubMed), and Web of Science until September 2023 and updated until June 2024. Human studies that were published in English were included without restricting other variables such as time, age, and gender. Results: At the first step, 10313 papers were found, and at the final step, nine studies were included in the systematic review, and four studies entered the quantitative analysis. The result showed that metabolic syndrome is significantly associated with minor alleles in the following genes: CAV-1 rs1997623 (OR = 1.44 (95% CI: 1.2, 1.86)), CAV-1 rs11773845, 22375-22375 del AC, and CAV-1 rs3807992. No significant association was found for CAV-1 rs926198 (OR = 1.61 (95% CI: 0.89-2.92)), and 22285 C>T. Caveolin mRNA level was increased in the cases of metabolic syndrome. CAV-1 rs1997623 A allele changes the transcription factor binding site to increase the attachment of EBF1. Conclusions: This results in the enhancement of promoter activity and further transcription of the caveolin-1 gene. In conclusion, individuals carrying minor alleles for the CAV-1 gene might have an increased risk for metabolic syndrome. With future studies focusing on the matter, this gene can be used as a screening tool for metabolic health to detect individuals with a higher genetic susceptibility to metabolic syndrome. © 2025 International Journal of Preventive Medicine.
Related Docs
View other Related Docs
1. Interactions Between Caveolin-1 (Rs3807992) Polymorphism and Major Dietary Patterns on Cardio-Metabolic Risk Factors Among Obese and Overweight Women, BMC Endocrine Disorders (2021)
2. Adherence to a Healthy Diet and Odds of Metabolic Syndrome: A Cross-Sectional Study, Clinical Nutrition ESPEN (2023)
3. The Role of Healthy Lifestyle in the Primordial Prevention of Metabolic Syndrome Throughout Lifetime: What We Know and What We Need to Know, Integrated Science (2022)
4. Association of Plant-Based Diets With Adropin, Atherogenic Index of Plasma, and Metabolic Syndrome and Its Components: A Cross-Sectional Study on Adults, Frontiers in Nutrition (2023)
5. Anthropometric Indices Predicting Incident Type 2 Diabetes in an Iranian Population: The Isfahan Cohort Study, Diabetes and Metabolism (2013)
6. Metabolic Syndrome in Iranian Patients With Systemic Lupus Erythematosus and Its Determinants, Clinical Rheumatology (2018)
7. Assessing the Predictive Value of Insulin Resistance Indices for Metabolic Syndrome Risk in Type 2 Diabetes Mellitus Patients, Scientific Reports (2024)
8. Effects of Probiotic Supplementation on Anthropometric and Metabolic Characteristics in Adults With Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Clinical Trials, Clinical Nutrition (2021)
Experts (# of related papers)
View all Related Experts
Nizal Sarrafzadegan (14)
Masoumeh Sadeghi (12)
Other Related Docs
9. The Product of Triglycerides and Glucose in Comparison With Fasting Plasma Glucose Did Not Improve Diabetes Prediction, Acta Diabetologica (2015)
10. Association of Dietary Pattern and Metabolic Syndrome in 15- to 49-Years-Old Women, Journal of Isfahan Medical School (2015)
11. Determinants of Incident Prediabetes and Type 2 Diabetes in a 7-Year Cohort in a Developing Country: The Isfahan Cohort Study, Journal of Diabetes (2015)
12. Effect of Cardiac Rehabilitation on Metabolic Syndrome and Its Components: A Systematic Review and Meta-Analysis, Journal of Research in Medical Sciences (2016)
13. Risk of Diabetes According to the Metabolic Health Status and Degree of Obesity, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2017)
14. Appetite Sensation Improvement by Synbiotic Supplementation in Patients With Metabolic Syndrome: A Randomized Controlled Clinical Trial, Food Science and Nutrition (2024)
15. Assessing Metabolic Syndrome Through Increased Heart Rate During Exercise, Acta Medica Iranica (2016)
16. Associations Between Fto Rs9939609 Polymorphism, Serum Vitamin D, Mental Health, and Eating Behaviors in Overweight Adults, Nutritional Neuroscience (2022)
17. Association of Single Nucleotide Polymorphisms in the First Intron of the Fat Mass and Obesity Associated (Fto) Gene With Obesity Risk in Asians: A Meta-Analysis, Progress in Nutrition (2019)
18. Does Supplementation With Pine Bark Extract Improve Cardiometabolic Risk Factors? a Systematic Review and Meta-Analysis, BMC Complementary Medicine and Therapies (2025)
19. The Association Between Blood Selenium and Metabolic Syndrome in Adults: A Systematic Review and Dose–Response Meta-Analysis of Epidemiologic Studies, Frontiers in Nutrition (2024)
20. Metabolic Syndrome and Nonalcoholic Fatty Liver Disease: Nutritional Approach for Prevention, Journal of Isfahan Medical School (2013)
21. Low-Carbohydrate-Diet Score and Metabolic Syndrome: An Epidemiologic Study Among Iranian Women, Nutrition (2015)
22. Appropriate Cut-Off Values of Waist Circumference to Predict Cardiovascular Outcomes: 7-Year Follow-Up in an Iranian Population, Internal Medicine (2012)
23. Effects of Pioglitazone on Asymmetric Dimethylarginine and Components of the Metabolic Syndrome in Nondiabetic Patients (Epicamp Study): A Double-Blind, Randomized Clinical Trial, PPAR Research (2013)
24. Absence of Association Between -1131T>C Polymorphism in the Apolipoprotein Apoa5 Gene and Pediatric Metabolic Syndrome, Iranian Journal of Pediatrics (2014)
25. The Role of Environmental Disruptor Chemicals in the Development of Non Communicable Disease, Advances in Experimental Medicine and Biology (2019)
26. Prevalence of Metabolic Syndrome and Its Components in the Iranian Adult Population: A Systematic Review and Meta-Analysis, Iranian Red Crescent Medical Journal (2015)
27. Comparison of Taqman Real-Time and Tetra-Primer Arms Pcr Techniques for Genotyping of Rs 8066560 Variant in Children and Adolescents With Metabolic Syndrome, Advances in Clinical and Experimental Medicine (2015)
28. Appropriate Waist Circumference Cut-Off Points Among Iranian Adults: The First Report of the Iranian National Committee of Obesity, Archives of Iranian Medicine (2010)
29. The Long-Term Association of Different Dietary Protein Sources With Metabolic Syndrome, Scientific Reports (2021)
30. Timing and Length of Nocturnal Sleep and Daytime Napping and Associations With Obesity Types in High-, Middle-, and Low-Income Countries, JAMA Network Open (2021)
31. Association of Quality and Quantity of Macronutrients Intake With Obesity, New Anthropometric Indices, Lipid Accumulation, and Blood Lipid Risk Index in Tehranian Women, Food Science and Nutrition (2024)
32. The Effects of Jujube (Ziziphus Jujube) on Metabolic and Mental Health Outcomes in Patients With Metabolic Syndrome: A Randomized Controlled Trial, Complementary Therapies in Medicine (2024)
33. Association of Dairy Consumption With Metabolic Syndrome, Hypertension and Diabetes in 147 812 Individuals From 21 Countries, BMJ Open Diabetes Research and Care (2020)
34. Does Oral Contraceptive Use Increase the Risk of Future Cardiovascular Events? Results From the Isfahan Cohort Study, Iranian Heart Journal (2016)
35. Decreased Na+/K+-Atpase Activity and Altered Susceptibility to Peroxidation and Lipid Composition in the Erythrocytes of Metabolic Syndrome Patients With Coronary Artery Disease, Annals of Nutrition and Metabolism (2019)
36. Moderate Replacement of Carbohydrates by Dietary Fats Affects Features of Metabolic Syndrome: A Randomized Crossover Clinical Trial, Nutrition (2014)
37. Effects of Mind Diet and Propolis Supplementation on Metabolic Syndrome Indices and Cognitive Function Among Patients With Metabolic Syndrome in Isfahan, Iran, 2024. a Rationale and Study Protocol for Randomized Controlled Trial, Health Science Reports (2024)
38. Association Between Plant-Based Diets and Metabolic Syndrome in Obese Adults From Iran: A Cross-Sectional Study, BMC Endocrine Disorders (2023)
39. Triglyceride-Glucose Index (Tyg) As a Novel Biomarker in the Era of Cardiometabolic Medicine, International Journal of Cardiology (2025)
40. A Systematic Review and Meta-Analysis of the Association Between Fish Consumption and Risk of Metabolic Syndrome, Nutrition, Metabolism and Cardiovascular Diseases (2020)
41. Apopulation-Based Metabolic Syndrome Risk Score and Its Determinants: The Isfahan Healthy Heart Program, Journal of Research in Medical Sciences (2014)
42. Comparison of Glycated Hemoglobin With Fasting Plasma Glucose in Definition of Glycemic Component of the Metabolic Syndrome in an Iranian Population, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2012)
43. Maternal Characteristics and Incidence of Overweight/Obesity in Children: A 13-Year Follow-Up Study in an Eastern Mediterranean Population, Maternal and Child Health Journal (2017)
44. Relationship Between Serum Resistin Concentrations With Metabolic Syndrome and Its Components in an Iranian Population, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2015)
45. Effect of Selenium Supplementation on Glucose Homeostasis and Lipid Profile in Women With Metabolic Syndrome: Randomized, Double-Blind, Placebo-Controlled Trial, Journal of Health System Research (2021)
46. Utility of Continuous Metabolic Syndrome Score in Assessing Risk of Type 2 Diabetes: The Isfahan Diabetes Prevention Study, Annals of Nutrition and Metabolism (2016)
47. Determinants of Incident Metabolic Syndrome in a Middle Eastern Population: Isfahan Cohort Study, Metabolic Syndrome and Related Disorders (2017)
48. Low-Density Lipoprotein Cholesterol and Metabolic Syndrome in an Iranian High-Risk Population, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2015)
49. Accuracy of Novel Anthropometric Indices for Assessing the Risk for Progression of Prediabetes to Diabetes; 13 Years of Results From Isfahan Cohort Study, Archives of Endocrinology and Metabolism (2024)
50. International Waist Circumference Percentile Cutoffs for Central Obesity in Children and Adolescents Aged 6 to 18 Years, Journal of Clinical Endocrinology and Metabolism (2020)